Dewpoint Therapeutics

The discovery of biomolecular #condensates was an astounding breakthrough. A revelation so profound, it completely transformed the understanding of cellular function and organization. Discover how Dewpoint is exploring the relationship between condensate biology and human disease to advance therapies for diseases previously thought undruggable. https://lnkd.in/expN2ZSR #DiscoverDewpoint #biotechnology

Revolutionary #condensate science with broad applicability across therapeutic areas, an #AI-powered state-of-the-art discovery platform, unrivaled expertise, and a culture that nourishes growth and innovation are only a few reasons why Dewpoint Therapeutics is One to Watch.  🧾 Read more in this article published in The Pharma Letter: https://lnkd.in/eyWr54yJ  

To support mental health at work, we believe in taking a holistic approach to Total Wellbeing and developing inclusive initiatives and programs that meet the needs of every team member. By building a culture of care, connection and self-awareness, we can be our best selves as we work together to develop novel therapeutics that will positively impact patients’ lives.  Learn more about Total Wellbeing at Dewpoint in this conversation with Nino Jeena, MBA, our Head of FP&A, and Lori Escobedo, Chief People & Administrative Officer. #WorldMentalHealthDay https://lnkd.in/gUaC2Uyz 

Congratulations to Dewpoint Principal Scientist Bede Portz Ph.D. for delivering an engaging talk at Discovery on Target! In his talk, Bede described how Dewpoint demonstrated that condensate biology enables us to identify and optimize #cmods that modulate historically undruggable targets like TDP-43 and MYC. Using MYC as an example, he highlighted our implementation of AI in both image analysis and chemistry to empower hit identification and expansion. 

At Dewpoint we’re flipping drug discovery on its head, harnessing the complexity of condensates with a phenotypic approach to uncover novel therapeutic candidates. To optimize, derisk and speed up discovery of new therapies, we’re incorporating cutting edge artificial intelligence (AI) and machine learning models across our drug discovery & development process, which is allowing us to discover drugs to treat complex diseases which have until now been considered untreatable.  To understand more about the unique tools Dewpoint has built and the potential of AI to optimize drug discovery and development, we spoke to Francis Carpenter, Dewpoint’s Head of Data Science and Engineering - read the full interview here: https://lnkd.in/gV8ZnXGx We also celebrate the pursuit of scientific innovation in AI and congratulate John J. Hopfield and Geoffrey E. Hinton, who were awarded the Nobel Prize in Physics “for foundational discoveries and inventions that enable machine learning with artificial neural networks.” https://lnkd.in/gTc68XRr

The brilliant spark of recognizing the important questions within the crumb trail of data, the relentless pursuit of scientific discovery, and the courage to challenge the status quo in light of new information stands at the heart of progress.  Congratulations to the 2024 laureates of the Nobel Prize in Physiology or Medicine, Drs. Ambros and Ruvkun, on their pioneering work on discovering microRNAs and for shedding light on the critical role of these cryptic non-coding RNAs in gene regulation!  https://lnkd.in/dX_zP_t9  

𝗗𝗿. Jesse Lai will present on Wednesday, 𝗢𝗰𝘁𝗼𝗯𝗲𝗿 𝟵, at the Society for Neuroscience’s Neuroscience 2024 conference. Join the talk to find out how a #condensate modulating drug (#cmod) reverses markers of #ALS pathology, by targeting a #condensatopathy shared by ~97% of patients. https://lnkd.in/gmF6U7ip

Condensates.com is pleased to welcome Dragomir Milovanovic, Principal Investigator - Molecular Neuroscience, German Center for Neurodegenerative Diseases, as an invited speaker in the Kitchen Table Talk series. Dr Milovanovic published seminal work that helps us understand the molecular mechanisms that control local organization of biomolecules at the synapse and how this organization regulates neurotransmission. 𝗝𝗼𝗶𝗻 𝘂𝘀 𝗮𝘁 𝘁𝗵𝗲 𝗗𝗲𝘄𝗽𝗼𝗶𝗻𝘁 𝗞𝗶𝘁𝗰𝗵𝗲𝗻 𝗧𝗮𝗯𝗹𝗲 𝘁𝗼 𝗹𝗲𝗮𝗿𝗻 𝗮𝗯𝗼𝘂𝘁 “𝗖𝗼𝗻𝗱𝗲𝗻𝘀𝗮𝘁𝗲 𝗯𝗶𝗼𝗹𝗼𝗴𝘆 𝗮𝘁 𝘁𝗵𝗲 𝘀𝘆𝗻𝗮𝗽𝘀𝗲”.  👉 Register for the talk here: https://lnkd.in/gyDfsy-6   #condensates #neuroscience

At Dewpoint, we are committed to heart health and to taking action on #WorldHeartDay. Together with Bayer | Pharmaceuticals we are working towards the goal of developing lifesaving therapeutics to reduce the over 20.5 million deaths each year from cardiovascular disease. 

We are thrilled to introduce “Liquid-liquid phase separation in cells” – a Dewpoint-sponsored 𝘕𝘢𝘵𝘶𝘳𝘦 𝘊𝘰𝘭𝘭𝘦𝘤𝘵𝘪𝘰𝘯, which compiles prominent papers in the field of biomolecular #condensate science. The collection of articles, independently selected by the editorial staff at Nature Portfolio, includes reviews and original research articles that discuss: 🔬 The role of biomolecular condensates as hubs for splicing regulation and protein aggregation 🗺 Mapping the composition of endogenous biomolecular condensates  ⚙ Molecular mechanisms by which cancer-driving proteins restructure chromatin to promote uncontrolled cell proliferation For a limited time, the publications included in the editorial collection are freely accessible to all. https://lnkd.in/gv6crsZD