Enamine Ltd.

In recent work, Vishwakarma et al. have introduced a novel method for direct deoxyazidation of primary and secondary alkyl alcohols (https://lnkd.in/dWuYZ_dr). This technique utilizes polyvalent SuFEx reagents such as Benzene-1,3,5-trisulfonyl fluoride (BTSF). BTSF facilitate the efficient conversion of alcohols into organic azides under mild conditions. Demonstrating broad substrate compatibility, this SuFEx-based approach is further elaborated by its application in a one-pot deoxyazidation-CuAAC reaction sequence for the late-stage functionalization of the drugs. 🛒 This reagent is available in our stock! https://lnkd.in/dKSrQbJd 💡 Enamine offers a broad range of reagents and product subsets for organic synthesis that facilitate a wide variety of transformations. Explore all of them here https://lnkd.in/gFMXnPKj

Recently, Boehringer Ingelheim announced its investigational drug, nerandomilast (BI 1015550), has successfully met the primary endpoint in the pivotal phase-III FIBRONEER-IPF trial. Cyclobutane rings are widely used in small-molecule drug development to restrict conformation, increase rigidity, fill a hydrophobic pocket, and direct key pharmacophores. Explore our wide range of high-quality Cyclobutane Building Blocks at Enamine Store and elevate your research to new heights. Visit us today! https://lnkd.in/gKveV84h

We’re excited to share an inside look at Enamine’s Riga facilities! This video takes you through our offices, labs, and storage facilities, where our team is set to expand research capabilities and develop partnerships within the local academic community, making the most of our dynamic space in Riga🇱🇻

A small, hard-to-synthesize spirocyclic amine developed by Enamine Ltd. chemists, with an elegant ¹H NMR spectrum.  For more details visit our website https://lnkd.in/dDP8A4JF Andrii K.

Molecule of the week EN300-45585231 More details: https://bit.ly/3C2tvgw #Enamine #molecule #chemistry #science #drugdiscovery

At Enamine, we provide comprehensive CADD support to accelerate every phase of drug design. From target modeling and hit identification to seamless lead optimization, our advanced computational methods deliver refined, impactful results.   💡 Services we provide: - Target Modeling and Molecular Dynamics Simulation - Virtual Screening of libraries of any size (Enamine Stock, REAL Space, xREAL, etc.) - ML-driven Virtual Screening & ADMET Predictions - Covalent & Noncovalent Molecular Docking - DNA/RNA Complex Modeling and more! Let's discuss how we can accelerate your drug discovery journey. To find out more: https://lnkd.in/d_3qGDpJ   #CADD #DrugDiscovery #MolecularModeling #Enamine #ComputationalChemistry #VirtualScreening #AI #ML #LeadOptimization #H2L

The introduction of a fluorine atom in potent αvβ6 inhibitors can significantly alter the physicochemical properties of the compound including the reduction of the pKaH of a neighboring amine, passive permeability, and the cell adhesion assay inhibitory concentration compared with nonfluorinated pyrrolidine analogues (https://lnkd.in/dSU7utdB). Explore how these innovations can take your drug discovery efforts to the next level! Check out our catalog 🛒 https://lnkd.in/dg-GV4Jw

Slow rotation around the amide bond arises from its planar geometric structure. Amide pyramidalization distorts this planarity, enhancing the dynamic properties of bioactive molecules, often affecting their distribution and solubility. Enamine offers a particularly rich collection of amines based on the 7-azabicyclo[2.2.1]heptane scaffold, a structure known for forming highly pyramidalized amides with fast rotation: https://bit.ly/40cGCWt Try our 7-azabicylo[2.2.1]heptanes in your research!

Chemspace and Enamine are excited to announce a collaboration to improve the delivery times of molecules from Chemspace Freedom Space. Enamine will utilize its extensive synthesis capabilities and production facilities in Europe, at its Frankfurt Site, allowing Chemspace to facilitate the rapid synthesis and delivery of Freedom compounds within 4-5 weeks. This joint effort further supports both companies’ missions to provide global research initiatives with the best possible tools and resources.   Learn more: https://lnkd.in/d9RNTqwM 

Please welcome Andrii Tolkunov - the chemist behind the molecule of this week. Congratulations! 👏 https://bit.ly/4eN3n7L #Enamine #molecule #chemistry #science #drugdiscovery