EvolutionaryScale

🌌 To help our understanding of how life evolves at the molecular level, scientists at EvolutionaryScale and the Arc Institute used #AI to create a protein modeled on 500M years of evolutionary change. ➡️ https://nvda.ws/3Q0jHXK ✨

ESM3: An open frontier language model for biology, accompanied by a paper in Science. Evolutionary Scale is a startup company that started out as a research project at FAIR (and some co-founders did their PhD at NYU). Amazing possibilities in protein design opened by ESM3: proteins that fluoresce, that digest plastics,...

ESM3: An open frontier language model for biology, accompanied by a paper in Science. Evolutionary Scale is a startup company that started out as a research project at FAIR (and some co-founders did their PhD at NYU). Amazing possibilities in protein design opened by ESM3: proteins that fluoresce, that digest plastics,...

We're thrilled to present ESM3 in Science Magazine. ESM3 is a generative language model that reasons over the three fundamental properties of proteins: sequence, structure, and function. Today we're making ESM3 available free to researchers worldwide via the public beta of an API for biological intelligence. Trained with over a trillion teraflops of compute, this is the first time a model of this scale has been trained for biology, pushing the frontier of AI for biological discovery and engineering. ESM3 learns to represent the immense complexity of protein biology, learning from billions of natural proteins. From this training it developed the capability to design proteins, responding to complex prompts combining atomic level details and high level instructions to generate new proteins. ESM3 can explore protein space far beyond natural evolution. We prompted ESM3 to generate a fluorescent protein at a far distance from any known fluorescent proteins, searching an unknown region of protein space, to discover a new fluorescent protein. We estimate this is equivalent to simulating five hundred million years of evolution. Read the paper: https://lnkd.in/eWdKRdCt Our blog post: https://lnkd.in/eqFR7BE8 Sign up for Forge, our new API for biological intelligence, now in public beta: https://lnkd.in/eSDkkNqd

🎁 I have an early holiday gift to my protein folding people! I've created a new plugin for PyMOL (called PyMOLfold) that allows you to fold protein sequences right in the GUI. Simply select your model of choice (such as EvolutionaryScale's ESM3 models, etc.) and paste in your amino acid sequence. Then, the folded protein will be loaded directly into your PyMOL session in a few seconds. Get PyMOLfold here: https://lnkd.in/eeTXkjqH (Also, I'm looking for developers/testers to help integrate more models into the tool. So, please fork my open-source code and add in your own functionality.) #proteinfolding #esm3 #pymol #boltz1 #chai1 #ai #genomics #bioinformatics #computationalbiology #aidrugdesign 🐖

Introducing ESM Cambrian, a new family of protein language models, which focuses on creating representations of the underlying biology of proteins. ESM C is a drop-in replacement for ESM2 that provides major improvements in both capability and efficiency. Information about protein structure in ESM C representations improves predictably with increasing training compute, demonstrating linear scaling across multiple orders of magnitude. Today we’re releasing ESM C 300M, and 600M with open weights. ESM C 6B is available immediately on Forge for academic use, and AWS Sagemaker for commercial use. ESM C will be on NVIDIA BioNemo soon. Read more on our website: https://lnkd.in/g8RQBmNR We’re excited to see what you build with ESM!

Introducing ESM Cambrian, a new family of protein language models, which focuses on creating representations of the underlying biology of proteins. ESM C is a drop-in replacement for ESM2 that provides major improvements in both capability and efficiency. Information about protein structure in ESM C representations improves predictably with increasing training compute, demonstrating linear scaling across multiple orders of magnitude. Today we’re releasing ESM C 300M, and 600M with open weights. ESM C 6B is available immediately on Forge for academic use, and AWS Sagemaker for commercial use. ESM C will be on NVIDIA BioNemo soon. Read more on our website: https://lnkd.in/g8RQBmNR We’re excited to see what you build with ESM!

🌎  Based in either New York or San Francisco: 🚀 Join EvolutionaryScale as we push the boundaries of AI and biology to transform life sciences research! We’re building the foundation models to make biology programmable, from molecules to cells. We're seeking a Cloud Infrastructure & Security Engineer to architect secure, scalable cloud services for our groundbreaking AI research and product platforms. If you thrive in high-impact environments, know how to design secure-by-default architectures, and want to work at the intersection of AI and biology, apply today.  #CloudEngineering #Security https://lnkd.in/e3cssBKn

An incredible day for our field. Congratulations David Baker, Demis Hassabis, and John Jumper!! https://lnkd.in/ehCMkxt

Join me on October 16 for the first-ever *AI Day* at Endpoints News. I'm so excited for this event to come to life and for you to join. The virtual event is free and registration is now open — sign up at the link below. I'll talk with some of the most important scientific and industry leaders that are determining just how far AI can reshape the drug R&D industry. We'll discuss different approaches across big pharma and startups, as well as what lies beyond the AlphaFold breakthrough for protein language models. The day will start with a fireside chat with none other than David Baker, director of the Institute for Protein Design, University of Washington. Baker's lab has continuously put out cutting-edge work in predicting and designing proteins with AI. And, oh, he also recently cofounded Xaira Therapeutics, which launched this year with a mere $1 billion in committed funding. Other speakers announced: Amgen CTO David Reese, EvolutionaryScale cofounder & ex-Meta scientist Alex Rives, and Inceptive CEO & transformer pioneer Jakob Uszkoreit. Sign up now: