Health and Environmental Sciences Institute (HESI)

The October edition of HESI's monthly newsletter, Insights, is now available! 📰🌍 Don't miss out on the latest updates on scientific advancements, collaborations, and SO MANY upcoming events! Dive into this month’s edition and stay informed. Check it out here 👉 https://lnkd.in/gkf2ke5m #HESI #ScientificAdvancement #Collaboration #Newsletter #Research #GlobalHealth #HESIInsights #OctoberEdition

🌿 New Advances in Botanical Safety 🌿 The HESI Botanical Safety Consortium’s Hepatotoxicity Working Group has published a proposed screening strategy to assess the hepatotoxicity and drug interaction risks of botanical supplements. With botanical products growing in popularity, ensuring their safety is more important than ever. 🔑 Key Highlights: 1. New Approach Methodologies (NAMs): Exploration of NAMs that are being proposed (in vitro and in silico models) to screen hepatotoxicity and botanical-drug interactions effectively. 2. Broad Botanical Testing: Testing a variety of botanicals through case studies, with assays evaluating cellular and molecular markers related to liver health. 3. Development of a Safety Toolkit: Creation of a toolkit to assist researchers in screening botanicals, informing further studies, and potentially reducing animal testing. This publication is valuable for toxicologists, regulatory bodies, and botanical product researchers interested in advancing #safetyassessment frameworks for botanical supplements. 📄A must-read! https://lnkd.in/gKht4S86 #BotanicalSafety #Toxicology

Looking forward to our session at ACT November 18th!

2nd International Pediatric Cardio-Oncology Conference Chair, Dr Steven Lipshultz opens conference with a shout out to the Health and Environmental Sciences Institute (HESI) Thrive grant program. Www.hesithrive.org. #survivorship #patientqualityoflife #drugsafety #translationalresearch

🚨 REMINDER! HESI's 2025 Call for Project Proposals is OPEN until January 17th! Is your organization tackling new scientific challenges? HESI offers a collaborative forum to develop methodologies, generate data, and build consensus on critical human or environmental health issues. Submit your priority emerging scientific proposals for a chance to shape a new multi-sector, collaborative HESI program in 2025. 📝 Proposals will be reviewed early next year. 📎 Full details and submission: https://lnkd.in/gpQFWAJ8 #HESI #ScientificCollaboration #Innovation #HealthResearch #EnvironmentalHealth #CallForProposals #ScientificInnovation

Launch of NAM Journal with Jinhee Choi, Fenna Sillé and Michelle Embry! Please see our editorial and please consider submitting your manuscripts to NAM Journal. Open access fees are waived for the next 2 years.

Celebrating an inspiring Health and Environmental Sciences Institute (HESI)' #ProteinSafetyWorkshop, held last week at the Universidade do Porto in collaboration with Joana Costa and Isabel Mafra! 🎉 It was an honor to bring together over 20 brilliant speakers and moderators, whose expertise and insights helped us achieve the workshop’s objectives. The event brought regulatory perspectives from five distinct geographical regions worldwide. Discussions reflected on over 30 years of learnings from novel foods/feed safety assessments, how to address challenging cases like 'Intractable Proteins' and considerations for applying New Approach Methodologies (NAMs) in this space. One major recurring theme that emerged was the crucial need for clearer #criteria to support decision-making at various stages—a foundational element that will empower regulators and product developers alike to navigate novel product safety assessments with confidence. My heartfelt thanks to everyone who participated and helped make this event such a success. Looking forward to the continued #collaborations and steps forward we’ll take together!

🤩 If you were at #SETACFortWorth I hope you caught this #NAMs dream team 🏆 ! We pulled back the curtain on New Approach Methods, sharing some trends happening across different sectors of the chemical industry and within the larger scientific community. Thank you to Audrey Bone for leading this session! She did an outstanding job! Huge thank you to Vurtice Albright from Dow, Kristin Connors from Procter & Gamble, and Julie Krzykwa from Health and Environmental Sciences Institute (HESI) for bringing your insights and expertise to the panel discussion. Thank you to all who participated in the session for your excellent questions. Society of Environmental Toxicology and Chemistry (SETAC) Bayer | Crop Science #TeamBayer

Do you wonder how reproducible #onestep #RTddPCR is? Reverse transcription can introduce significant #variation in #geneexpression analysis (see for example this 2015 paper from Bustin et al. https://lnkd.in/eJKtexkG). So what about one-step RT-ddPCR? In this recent publication https://lnkd.in/evEd6h5M by the Health and Environmental Sciences Institute (HESI) CT-TRACS committee, Yasuda et al. aimed to detect undifferentiated pluripotent stem cells (#PSCs) in cell therapy products (#CTPs) to ensure biosafety. Their publication shows that on-step RT-ddPCR is: 🧬#reproducible: One-step RT-ddPCR was extremely reproducible across five sites, multiple markers, and multiple ddPCR instruments — all without normalization for input! 🧪#precise: Variation was mainly due to the #pre-PCR workflow. (In this case, it meant culturing #iPSCs, spiking them into cardiomyocytes, and performing RNA extraction.) ⚗#sensitive: One-step RT-ddPCR was exceptionally sensitive, detecting as low as 0.0003% (3 cells per million) residual iPSCs in CTPs. In conclusion, one-step RT-ddPCR demonstrates excellent reproducibility!   #ddPCR #stemcells #digitalPCR #iPSC #ATMP #geneexpression #dPCR

🎗️❤️ "Making Patient Quality of Life an Active Research Priority" HESI Executive Director, Syril Pettit, is honored to be giving the Dr. Jacob Adams Memorial Lecture at the 2nd International Pediatric Cardio-Oncology Conference in Pittsburgh, PA, on November 8, 2024. This is a unique opportunity to engage with innovative ideas and join a crucial discussion on improving survivorship care. Details: https://ow.ly/ksHI50TOscK #CardioOncology #PediatricOncology #HESI #QualityOfLife #Survivorship