Hydrosome Labs LLC

THIS MONTH IN ULTRAFINE BUBBLES: Ultrafine bubbles and liver health after alcohol consumption Here is a summary of a timely article from the Biological and Pharmaceutical Bulletin. Key takeaways and future implications for UFBs from Hydrosome Principal Scientist, Nick Jackowetz, PhD:   - The rats that drank the hydrogen ultrafine bubble water had less damage to their liver after alcohol consumption compared to those drinking regular water. - The hydrogen seemed to act like a shield, protecting the liver cells from the harmful effects of alcohol. - The tiny powerhouses in liver cells (called mitochondria) worked better in the rats that drank the hydrogen water. - The more concentrated the hydrogen bubbles were in the water, the better the protective effects. Why is this interesting? It shows that we might use these tiny bubbles to deliver helpful substances, like hydrogen, directly to our body's tissues. This could open up new ways to prevent or treat various health issues. The best part is that it's as simple as drinking water—no needles or complicated procedures are needed. While more research is needed, this study suggests that these invisible, hydrogen-filled ultrafine bubbles might one day help us stay healthier, especially when protecting our liver from alcohol damage. Since this is a rat study, we'd still need to see if this would work the same for humans. But it's an intriguing glimpse into how something as simple as water with special bubbles could make a big difference in our health. At Hydrosome Labs, we're constantly innovating new ways to use ultrafine bubbles, including adding different gases to them for various applications. These results open many new avenues for research in many different fields.

Tiny Bubbles, Huge Potential: Nick Jackowetz on Life Science Podcast Thanks to Chris Conner for the great interview with Hydrosome's Nick Jackowetz on the Life Science Podcast.

COSMETICS AND TOILETRIES EXPERT PANEL WITH HYDROSOME Thanks to C&T for including Hydrosome President Bob Jacobs on a recent expert panel. Key excerpt below. You may have to log in as a guest to view the entire article. Simpler, AI-enabled and Powered by Ultrafine Bubbles President of Hydrosome Labs, Bob Jacobs sees consumer demand for clean beauty as a driver for formulations with fewer, simpler ingredients. “This is driven by a desire to have fewer chemicals in contact with our skin, and an increasing number of people with sensitivity to the chemicals being added in today’s formulations,” he explains. “Unfortunately, the list of pure and natural ingredients that deliver superior preservation, stability and efficacy is quite short.” Jacobs continues, “We believe these trends will continue as technology catches up and better meets the desire of consumers. The use of AI in the identification of natural compounds and in the evaluation of skin types will allow for improved degrees of freedom and personalization in formulations.” Per Jacobs, one promising technology that will enable improvements in preservation, stability and efficacy across the entire spectrum of clean beauty is the use of ultrafine bubbles. “The technology was first discovered in Japan about 20 years ago,” he writes. “Its use in beauty care is relatively new, but it holds tremendous promise for increasing efficacy, preservation and active ingredient stability.” Jacobs highlights Hydrosome H2O (Aqua) as the leading brand focused on the beauty care category. “Their technology works by infusing the existing DI water used in formulations with ultrafine bubbles in the range of 50-100 nm. Those bubbles consolidate active ingredients on their surface and deliver them deeper and more effectively to skin cells. They have also shown the ability to improve preservation and ingredient stability while lasting over two years in formulations.”

HYDROSOME'S BOB JACOBS WITH INSIGHTS FROM COSMOPROF As we reflect on an inspiring and insightful recent Cosmoprof show, we thought we'd share some of our observations on industry trends that caught our attention. 𝗖𝗹𝗲𝗮𝗻 𝗕𝗲𝗮𝘂𝘁𝘆 - This is an established trend not going away anytime soon. There were a large number of brands like Mixsoon US and Selenus from Korea or start-ups like The Heritage Collection, Fleurissent Skincare and Biotic Beauty with innovative clean products. 𝗧𝗲𝗰𝗵 𝗘𝗻𝗮𝗯𝗹𝗲𝗱 𝗕𝗲𝗮𝘂𝘁𝘆 - Technology can enable personalized beauty regimens continues to advance and become more accessible. Testing is moving beyond just skin type to looking at the make up of the skin microbiome and customizing products to support it. 𝗦𝗲𝗻𝘀𝗼𝗿𝘆 - Beyond fragrance, texture is becoming an increasingly important aspect of beauty products. The continued rise of serums and products with a unique sensorial application experience was evident at the show Encouragingly, Hydrosome H2O has promise across all of these trends. We help formulators maintain or improve efficacy while eliminating chemical permeation enhancers. We have also seen sensory improvements in application and broader research on ultrafine bubbles points to benefits for the microbiome. We are just beginning to discover the many benefits of ultrafine bubble technology for skin care.

Congrats to our partner Meaningful Beauty on their 20th Anniversary. And thanks to Happi Magazine for its shout-out of Hydrosome Labs.

Tune in for a great interview on the Biotech Startups Podcast with Hydrosome advisor Shekhar Mitra, Ph.D. on lessons learned from a lifetime of innovation. Thanks to Jon Chee for the opportunity and the great platform for stories on technology, start-ups, and more.

HYDROSOME LABS FINALIST FOR BEAUTY MATTER NEXT AWARD Thanks to Beauty Matter for recognizing Hydrosome for the innovative use of a new ingredient associated with the formulation of cosmetic products.

Thanks Nadav Berger for the shout out! Looking forward to talking further about the disruptive impacts of our technology on the food industry.

THANKS CINDY CRAWFORD FOR THE KIND WORDS ABOUT HYDROSOME TECHNOLOGY...