Inside Precision Medicine

Novartis Inks $150M Molecular Glue Deal with Monte Rosa Monte Rosa Therapeutics has inked an agreement with Novartis to advance its molecular glue degrader (MGD)-based medicines, including its lead compound, MRT-6160.

Gene Editing Insights Progress Delivery Inside Body U.S. researchers have revealed precise, molecular mechanisms underlying CRISPR/Cas9 gene editing that can help avoid detrimental off-target effects and could help progress the accurate delivery of cellular therapies directly within the body. Dana-Farber Cancer Institute, Harvard Medical School, University of Pennsylvania Perelman School of Medicine, Children's Hospital of Philadelphia

APOL1 Gene Variants in People from West Africa Significantly Increase Chronic Kidney Disease Risk The implications of this study extend beyond West Africa, the researchers noted as other studies have also found APOL1 variants in populations from Europe, Asia, South American and Central America. The new study was led by researchers at The National Institutes of Health (NIH).

The State of AI in Drug Discovery is happening this Wednesday, 10/30, and you won't want to miss it! This FREE virtual summit starts at 11am and ends at 3pm EST, featuring an exciting lineup of sessions showcasing the latest advances, challenges and concerns regarding the deployment of AI in biotech, with particular emphasis on disrupting the drug discovery process. Watch industry luminaries Jen Nwankwo (1910 Genetics) , Philip Tagari (insitro), Alex Zhavoronkov (Insilico Medicine), and Jacob Berlin (Terray Therapeutics) in their session "Key Considerations for Small Molecule Drug Discovery". To watch this session and all the others, including Nobel Laureate David Baker's keynote, be sure to register now, for free: https://hubs.li/Q02W5nV-0

Huntington’s Discovery Could Lead to New Treatments U.K. and German researchers are hopeful that their discovery of a key biochemical change involved in the development of Huntingdon’s disease could lead to its early detection and treatment. Liliana Minichiello, PhD, from the University of Oxford was the study's lead author.

Semaglutide May Cut Alzheimer’s Risk in Type 2 Diabetes The Case Western Reserve University School of Medicine results, which were based on data from a national health records database, were consistent across different subgroups— including obesity status, gender, and age.

Yes, We Can: BridgeBio Shares Positive Gene Therapy Data in Canavan Trial BridgeBio presented positive data on gene therapy BBP-812 for Canavan Disease at the 31st annual European Society for Cell and Gene Therapy (#ESCGT) meeting. In this article Eric David, MD, from BridgeBio spoke with Jonathan D. Grinstein, PhD.

Tertiary Lymphoid Structures Linked to Improved Treatment Outcomes in Liver Cancer While the Johns Hopkins Kimmel Cancer Center research can help clinicians better determine outcomes prior to surgery for hepatocellular carcinoma (HCC) patients, it also points to finding ways to induce the formation of tertiary lymphoid structures in patients that don’t respond, as a method to improve the efficacy of ICI treatment.

Join us THIS Wednesday, October 30th for GEN's inaugural AI in Drug Discovery summit! This free virtual event will feature thought-leaders, researchers and AI entrepreneurs across industry and academia to showcase the latest advances, challenges and concerns regarding the deployment of AI in biotech, with particular emphasis on disrupting the drug discovery process. Among the industry leaders joining us is Najat Khan, PhD (Recursion who will be giving a keynote presentation on growing AI in the drug discovery industry. Be sure to tune in Wednesday morning for the full lineup. To register for free, visit: https://hubs.li/Q02VY4960

Healthy Diet Reduces Risk of Prostate Cancer Progression This finding further supports the idea that men with lower risk prostate cancer can be carefully monitored in lieu of undergoing harsh treatments. Zhuo Tony Su, MD, a fifth year resident at the Brady Urological Institute and the Johns Hopkins Medicine, led this study.