JMSACL (Journal of Mass Spectrometry & Advances in the Clinical Lab)

Source: (Clinica chimica acta; international journal of clinical chemistry) Developed LC-MS/MS method quantifies 23 TKIs in plasma; evaluated anlotinib trough concentration's relation to toxicities. Analyzed 55 cancer patients, found positive correlation between anlotinib levels (≥17.655 ng/mL) and grade ≥ 3 toxicities. Low platelet counts also linked to higher toxicity risk. Logistic model improved prediction of toxicities using both factors.

Source: (European journal of haematology) Developed method for measuring ruxolitinib (RUX) in steroid-refractory GvHD. Analyzed 48 blood samples from 29 patients. Results showed variable plasma concentrations across doses. Non-optimal conditions resulted in lower concentrations. Four non-responding patients had low RUX levels. Validated liquid chromatography-tandem mass spectrometry method highlights the need for RUX pharmacokinetics monitoring.

Source: (Journal of bioinformatics and computational biology) 4D-DIA proteomics and machine learning identified biomarkers for psychological stress. Current evaluations are subjective; this study aims for objective measures. Using SVM and SHAP, Glyceraldehyde-3-phosphate dehydrogenase and Fibronectin showed 92% AUC, 86% accuracy, 79% F1 score, and 83% sensitivity, indicating potential in stress detection and prevention of disorders.

Source: (Journal of neural transmission (Vienna, Austria : 1996)) Study compares UHPSFC-MS and UHPLC for measuring steroid hormones, optimizing conditions for accuracy. UHPSFC-MS outperforms UHPLC in five of seven columns tested, enhancing high-throughput analysis for research and diagnostics.

Source: (Methods in molecular biology (Clifton, N.J.)) Endocannabinoids are key lipid neurotransmitters in health. This chapter outlines methods for quantifying endocannabinoids and steroid hormones in hair and saliva using liquid chromatography-tandem mass spectrometry (LC-MS/MS). It details sample preparation techniques and troubleshooting tips for effective analysis.

Source: (Endocrinology and metabolism (Seoul, Korea)) LC-MS/MS accurately measures plasma aldosterone concentration (PAC) and correlates well with radioimmunoassay (RIA) in primary aldosteronism (PA) screening in a Korean population. Study of 127 patients showed a 29.3% mean bias for PAC between methods, with equivalent levels at 11.7 ng/dL (LC-MS/MS) and 15 ng/dL (RIA). Optimal cutoff values for sensitivity and specificity adjustments in PA screening using LC-MS/MS are necessary.

Source: (Analytical chemistry) Developed porous Co₃O₄/CuO nanocages with p-p heterojunctions enhance mass spectrometry for plasma metabolic analysis. This method enables rapid, sensitive screening and accurate diagnosis of epidural-related maternal fever (ERMF) using minimal plasma samples, achieving AUCs of 0.887-0.975 for warning and 0.850-1.000 for diagnosis, improving clinical decision-making and potentially reducing ERMF incidence.

Source: (Frontiers in molecular biosciences) VOCs are gaseous compounds often undetected in metabolomics. Mass spectrometry innovations enable VOC detection, linking profiles to multi-omic data for genotype/phenotype insights. This review discusses on-line and off-line VOC profiling methods, tracing technological advancements and applications in microbiome and diagnostics.

Source: (eLife) Study develops antimicrobial drug recommender system using MALDI-TOF MS and dual-branch neural networks to predict antimicrobial resistance profiles. This improves treatment efficiency, effectiveness, and cost. Models outperform previous methods and can be adapted to other clinical data. Code available on PyPI and GitHub.

Source: (Scientific reports) Developed a validated LC-MS/MS method for quantifying testosterone and allopregnanolone isomers in serum of ages 5-85. This method shows sex and age effects, outperforming traditional immunoassays in detecting differences. Results aid in understanding neurosteroids' health roles.