K50 Ventures

We're thrilled to announce that Mindstate Design Labs has received both FDA & EMA approval to begin human trials in the development of our neurotech platform for designing altered states. It’s time to move beyond “psychedelics” and begin the precision design of mood, cognition, and perception. Our Osmanthus platform is driven by direct human experience. It represents the scaling, quantification, and systematization of the Shulgin tradition of direct experimentation. - We’ve scaled with 70,000 human reports made possible by Shulgin’s chemistry and the psychonauts who followed in his footsteps & detailed their experiences. - We’ve quantified the latent space of subjective experience with the semantic dimensions of LLMs. - We’ve systematized the linkage between psychoactivity and biochemistry with thousands of assays of psychedelics against the sites in the brain to which they bind. The psychedelics were the tools, not the end game. They were for psychiatry what the microscope was for biology and what the telescope was for astronomy. We’ve used the tools to map the biological basis of the varieties of psychedelic effects, and we’re now moving into human trials to use those tools to design both existing and novel altered states. Our first line of psychotropic effects is built on the single base formula of the Shulgin psychedelic 5-MeO-MiPT, commonly called moxy – a “psychedelic tofu”. At normalized clinical doses there are some basic psychedelic effects but no mystical experiences or entities or blissful formless voids or immersive memory replays. 5-MeO-MiPT is a blank canvas on which to paint infinite possibilities. We take a combination approach where we break apart the serotonergic action with 5-MeO-MiPT and recombine it, one by one, with a collection of other compounds that carry pharmacologies we’ve identified as modulating one or more of the 600+ psychedelic effects we’ve catalogued. We don’t need to eliminate the psychoactive effects of psychedelics. We need the ability to choose the effects that are helpful – to transform these largely effective but unpredictable messes of psychoactive effects into a series of precision-targeted psychoactive profiles. We need to go beyond psychedelics and into mindstate design. https://lnkd.in/eYb9m9yB

“A Arvo olha o serviço que foi prestado, analisa a composição desse atendimento, com base em toda experiência acumulada nas transações que já processamos até aqui, comparando com o que é esperado, complementando com conhecimento técnico de saúde. E indica se esse custo deveria estar lá ou não” São mais de R$ 82 bilhões de valor em sinistro processado que tornam nossas inteligências ainda mais capazes de identificar padrões complexos e anomalias que passam despercebidos pelos métodos convencionais. Saiba mais na matéria super completa que a EXAME fez divulgando a nossa recente captação de R$ 25 milhões em rodada liderada pela Canary e K50 Ventures,  com participação de Latitud, Preface Ventures e Endeavor! https://lnkd.in/dFEun2Ty

“A Arvo olha o serviço que foi prestado, analisa a composição desse atendimento, com base em toda experiência acumulada nas transações que já processamos até aqui, comparando com o que é esperado, complementando com conhecimento técnico de saúde. E indica se esse custo deveria estar lá ou não” São mais de R$ 82 bilhões de valor em sinistro processado que tornam nossas inteligências ainda mais capazes de identificar padrões complexos e anomalias que passam despercebidos pelos métodos convencionais. Saiba mais na matéria super completa que a EXAME fez divulgando a nossa recente captação de R$ 25 milhões em rodada liderada pela Canary e K50 Ventures,  com participação de Latitud, Preface Ventures e Endeavor! https://lnkd.in/dFEun2Ty

Despite all the noise coming out of DC these days, work is still getting done at the The White House. Last week I was lucky enough to join a great group at the White House for the inaugural meeting of the Americas Partnership Angel Investor Network, which is part of the Americas Partnership for Economic Prosperity or “Americas Partnership" that President Biden announced in 2022 to tackle economic inequality, foster more good jobs, and restore faith in democracy in the region. K50's investments over the past decade in hundreds of purpose-driven founders looking to solve vital issues in the Americas prove that there is tremendous opportunity with this kind of initiative. Thank you Jake Sullivan, Samantha Power, Ramon Escobar, Omar Paganini, Ines Bonicelli, among others, for convening this incredible group of foreign ministers and investors across the Americas to discuss how we can continue to drive investment into start-ups who are on the front lines solving problems affecting all of us. From just our small group, we pledged to invest $1B+ into the region through 2027 - shout out the founders of Endeavor, HTwenty, Kayyak Ventures, Salkantay Ventures, Partners for Growth, 500 LatAm, and Valor Capital Group. I'm looking forward to the next event and bringing more people into the group, so please ping me if you are interested in learning more. Main takeaways from the event: 1. The LATAM macro narrative needs to be more clearly communicated. - < 2.5% of dollars deployed to that of the U.S. albeit being the 3rd largest GDP…AND - Tech market cap to total GDP is just 2% vs. India (11%), China (20%), and US (64%) 2. ⁠As an ecosystem, we need to be focused on solving the complex and multi-faceted problems. This will typically take more than just software and capital. We also must have multilateral support, patient capital, patient founders and talent with the playbooks necessary to build value long term. No more copycats and get rich schemes; this won’t work in the region. 3. ⁠Dependable capital sources for funds at the LP and GP levels are necessary; government can help by allowing pensions to invest in the region. Family offices in the region need to be convinced of the opportunity in their back yard too; if they aren’t investing why would a U.S. investor or pension invest. #venturecapital #Americas #WhiteHouse

K50 Ventures is hiring a Director of Finance to lead and grow our platform! We are looking for a rockstar with 6 years of work experience, with a track record of managing a startup, PE or Venture firm and loves finance and startups. There is a path to partner with this role. This is a remote role and we’re particularly interested in candidates based in LATAM, where 40% our investments have been made, a lot of our LPs are from, and our Senior Investment Partner Daniel Vásquez leads the region for us from Medellín. Role JD here: https://lnkd.in/eFwBUQVV

🇺🇸 I am proud and humbled to announce that Tivita has emerged from stealth mode and secured $6M in funding, led by FinTech Collective, with participation from K50 Ventures, MAYA CAPITAL, and SSV. In 2023, my co-founder Amilton and I embarked on an ambitious mission to make healthcare providers thrive by setting their back office on autopilot. We have been incredibly fortunate to have: - Amazing families who supported and cheered us through the ups and downs - Mentors, early supporters, and investors who believed in us - A brave and outstanding team who live by strong shared values - Clients who trusted us and are building together - Partners who made this possible—and fast! Learn more about how we’re bringing financial excellence to healthcare providers at www.tivita.com Gabriela, Carlos, Brooks, Gareth, Cristobal, Adriel, Ryan, Lara, Monica, Antonio, Cesar, Travis, Parker, Lucas, Renato, Tiago, Jesus, José, Eduardo, Fabio, Samy, Belen, Emma, Felipe, Aurélien, Ricardo #HealthTech #Fintech #Tivita 🇧🇷 Estou muito orgulhoso e animado em anunciar a Tivita publicamente, junto com a rodada de R$ 33 milhões, liderada pela FinTech Collective, com a participação da K50 Ventures, MAYA Capital e SSV. Em 2023, eu e o Amilton embarcamos na ambiciosa missão de impulsionar o sucesso de clínicas e consultórios, eliminando tarefas manuais e colocando a gestão financeira no piloto automático. Fomos extremamente privilegiados por ter: - Famílias incríveis que nos incentivaram ao longo dos altos e baixos - Mentores, apoiadores e investidores que acreditaram em nós (muitos quando éramos só uma ideia no papel) - Um time corajoso e excepcional que compartilha dos mesmos valores - Clientes que confiaram e estão construindo junto - Parceiros que tornaram isso possível—em tempo recorde! Se você conhece uma clínica ou consultório que quer alcançar excelência financeira, indique em www.tivita.com

Last week, I sat down with Jill Malandrino at Nasdaq and David Mullings at Blue Mahoe to discuss the opportunities arising in LATAM and the Caribbean on Tradetalks. It was a fast paced, insightful conversation to the common misconceptions investors make and the range of opportunities that entrepreneurs should be solving in the region. Video here: https://lnkd.in/ecGWGF5n After nearly 8 years of investing and paying my dues in the region, I remain excited by these core tenants: - 3rd Largest GDP in the world; LatAm as a region represents approx. 8% of the world’s population and $7T GDP. - Is Underinvested; receives <1% of VC dollars and if the technology market cap as a % of total market cap caught up to the US/China, it would be a multi-trillion dollar opportunity in returns! - Fastest growing region in the world; the economy is growing faster than the global avg and is the fastest growing region for e-commerce and the cloud industry. How the market has evolved in the past 10-15 yrs and what’s in/out of favor? - There is a much bigger base of great local VC funds and good tech talent coming out of local tech schools and trained by both tech startups and big tech players. - Out: low-margin tech-enabled distribution businesses, non-differentiated lending/fintech offerings, high valuations at the early stage - In: - Digitizing the Healthcare Ecosystem from pre-auth to payment; Healthcare has notoriously been avoided in LATAM, typically because there’s a small perceived private mkt and large risk of relying on government customers. Brazil is the second largest private healthcare system in the world and it’s one of the most exciting spaces in the region because of the white space caused by a lack of digital adoption. There’s a real ability to leapfrog with new technology that’s focused on building core infrastructure. - Building a sustainable future; The global mkt is realizing that there is no climate sustainability without LatAm playing a central role in the solution, be it conservation, food supply, energy transition, or carbon capture. I think we’ll see global tech climate companies being born and scaling to become global champions. - Minimizing the Productivity Gap for SMBs; small and micro businesses employ nearly 60% of the workforce, yet contribute 25% of the GDP. This is a large number but a 2X lag in productivity compared to SMBs in the US which we think comes from lack of digital adoption and financing. Vertically integrated platforms and embedded services that empower these platforms will close this gap. What LATAM needs more of? - There is institutional capital for PE and infrastructure but very very little for VC. LatAm institutions, governments, and Family businesses need to invest more in VC and regulations need to change. Many countries in the region, like Colombia, don’t allow pension funds to invest in VC, which is bad both for the ecosystem and for the future pension holders.