Mainline Scientific

Mainline Scientific

Biotechnology Research

Malvern, Pennsylvania 55 followers

Powerful Life Science instrumentation solutions for answers to your molecular interaction analytical challenges

About us

Mainline Scientific LLC is a bio-analytical technology start up focused on developing robust, innovative life-science instrumentation. We are currently introducing our new Emanant PWR (Plasmon Waveguide Resonance) Spectrometer. Come follow us and check out our web page if you want to keep up to date with one of the newest Life Science lab instrumentation technologies!

Industry
Biotechnology Research
Company size
2-10 employees
Headquarters
Malvern, Pennsylvania
Type
Privately Held
Founded
2017
Specialties
Label-free Monitoring, Analytical Chemistry, Molecular Interaction Characterization, Biological System Monitoring, Kinetic Studies, Surface Chemistry, Aggregation Monitoring, Refractive Index Monitoring, Real-time Binding Interaction Monitoring, Protein Chemistry, and Biomarkers

Locations

  • Primary

    5 Great Valley Pkwy

    Suite 180

    Malvern, Pennsylvania 19355, US

    Get directions

Employees at Mainline Scientific

Updates

  • View organization page for Mainline Scientific, graphic

    55 followers

    Nice overview of the use and advantages of exosomes as biomarkers for medical diagnostic and prognostic purposes #BiomedicalInnovation #Diagnostics #Exosomes

    View profile for Jack (Jie) Huang MD, PhD, graphic

    Chief Scientist I Founder/CEO I Visiting Professor I Medical Science Writer I Inventor I STEM Educator

    Exosomes as Biomarkers Exosomes as biomarkers represent a breakthrough in diagnostics and personalized medicine. Exosomes are small extracellular vesicles secreted by cells that carry a variety of proteins, lipids, and nucleic acids (such as mRNA, miRNA, and DNA) that reflect the physiological and pathological status of their parent cells. This makes them highly valuable as biomarkers for diagnosing and monitoring diseases. One of the main advantages of exosomes as biomarkers is that they are found in biological fluids such as blood, urine, saliva, and cerebrospinal fluid. Their presence in these easily accessible samples enables non-invasive or minimally invasive diagnostic procedures. This is in stark contrast to traditional biopsies, which are invasive and often uncomfortable for patients. Exosomes in body fluids carry molecular signatures that reflect the status of tissues (including tumors) and can therefore be used to monitor disease progression or treatment response in real time. For example, in cancer, tumor-derived exosomes (TDEs) carry oncogenic proteins, miRNAs, and DNA fragments that can be detected in the bloodstream. These exosomes provide insights into tumor heterogeneity and metastasis, helping clinicians monitor disease progression, detect early recurrence, or evaluate treatment efficacy. Likewise, exosomes from immune cells can serve as biomarkers for autoimmune or inflammatory diseases because they carry molecules that reflect immune status. Exosomes also show promise as prognostic tools, predicting the likelihood of disease recurrence or treatment response. For example, specific miRNA profiles in exosomes have been associated with chemotherapy resistance in cancer patients, allowing clinicians to adjust treatment accordingly. In summary, exosomes are emerging as a powerful tool in the biomarker field, providing a non-invasive method for diagnosing, monitoring, and predicting disease progression. Their potential to provide real-time information about disease status and treatment response is changing the landscape of personalized medicine and diagnostics. References [1] Md Nurul Huda et al., ACS Biomaterials Science & Engineering 2021 (https://lnkd.in/eg7UByn6) [2] Maria Mosquera-Heredia et al., Biomedicines 2021 (doi: 10.3390/biomedicines9081061) [3] Yupeng Huang et al., Frontiers in Immunology 2020 (DOI:10.3389/fimmu.2020.01509) #Exosomes #Biomarkers #PersonalizedMedicine #Diagnostics #CancerResearch #NonInvasiveTesting #ExosomeBiomarkers #BiomedicalInnovation #DiseaseMonitoring #ExosomeTherapy #PrecisionMedicine #BiotechResearch #HealthcareInnovation #Newsletter #MedicalAdvances

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  • View organization page for Mainline Scientific, graphic

    55 followers

    The 2024 Nobel prize has been awarded to three recipients for new discoveries related to proteins. One half of the prize is for work based on computational protein design. The other half is awarded for work on protein structure prediction. Congratulations to the recipients of the award.

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    901,882 followers

    BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 Nobel Prize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”   The Nobel Prize in Chemistry 2024 is about proteins, life’s ingenious chemical tools. David Baker has succeeded with the almost impossible feat of building entirely new kinds of proteins. Demis Hassabis and John Jumper have developed an AI model to solve a 50-year-old problem: predicting proteins’ complex structures. These discoveries hold enormous potential.   The diversity of life testifies to proteins’ amazing capacity as chemical tools. They control and drive all the chemical reactions that together are the basis of life. Proteins also function as hormones, signal substances, antibodies and the building blocks of different tissues.   Proteins generally consist of 20 different amino acids, which can be described as life’s building blocks. In 2003, David Baker succeeded in using these blocks to design a new protein that was unlike any other protein. Since then, his research group has produced one imaginative protein creation after another, including proteins that can be used as pharmaceuticals, vaccines, nanomaterials and tiny sensors.   The second discovery concerns the prediction of protein structures. In proteins, amino acids are linked together in long strings that fold up to make a three-dimensional structure, which is decisive for the protein’s function. Since the 1970s, researchers had tried to predict protein structures from amino acid sequences, but this was notoriously difficult. However, four years ago, there was a stunning breakthrough.   In 2020, Demis Hassabis and John Jumper presented an AI model called AlphaFold2. With its help, they have been able to predict the structure of virtually all the 200 million proteins that researchers have identified. Since their breakthrough, AlphaFold2 has been used by more than two million people from 190 countries. Among a myriad of scientific applications, researchers can now better understand antibiotic resistance and create images of enzymes that can decompose plastic.   Life could not exist without proteins. That we can now predict protein structures and design our own proteins confers the greatest benefit to humankind. Learn more Press release: https://bit.ly/3TM8oVs Popular information: https://bit.ly/3XYHZGp Advanced information: https://bit.ly/4ewMBta

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  • View organization page for Mainline Scientific, graphic

    55 followers

    If you're at the #DiscoverBMB 2024 conference in San Antonio, come visit Mainline Scientific at booth number 307 to learn about our Molecular Interaction Analysis platform, the Emanant PWR Spectroscopy system. We look forward to sharing some of the latest technology developments that may apply to your work.

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  • View organization page for Mainline Scientific, graphic

    55 followers

    If you are attending the Peptalk 2024 conference this week in San Diego, stop by booth 709 in the exhibit hall to hear about our spectroscopy technologies for molecular-interaction analysis. Monitor antigen-antibody, protein-protein interactions and more, using technologies naturally compatible with biological systems. Our technology is cell membrane friendly. #peptide #peptides #cellbiology

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  • View organization page for Mainline Scientific, graphic

    55 followers

    Mainline Scientific announces new Staff and Expansion of Development and Analytical Capabilities.  Mainline Scientific is excited to announce the move to our larger development and analytical testing spaces, located in Malvern, Pennsylvania.  In addition to our new space, we have recently hired two Application Scientists. We have received strong interest at multiple conferences in the Emanant PWR Spectroscopy System for analysis of molecular interactions. The recent addition of our scientists and larger facility will further enable our progress and capabilities to demonstrate the unique benefits of our instrumentation for molecular interaction analysis. If you study molecular interactions as part of your work, please contact us to discuss how this technology may apply to your work.

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