Metabolic Solutions

When you’re designing a clinical trial, your goal is to ensure robust data and high participant retention—but are your current methods meeting those goals? Designing a successful trial means leveraging every tool at your disposal to gather complete, accurate data.   Traditional blood tests may seem sufficient, but are they really giving you the complete picture of liver function in your clinical trials? Blood draws can be invasive, reducing participant retention and limiting the frequency of testing. This can lead to gaps in data and delayed insights into drug efficacy. Metabolic Solutions’ non-invasive breath tests offer the solution.   By providing easily repeatable, real-time data on liver function, breath tests allow for more frequent assessments without compromising patient comfort or compliance. Improve the depth of your clinical trial data by integrating breath tests into your study design. Contact us today to learn how our breath tests can give you the critical insights you’re missing. https://lnkd.in/er_X2ub6 #LiverHealth #LiverDiseaseResearch #ClinicalTrials #LiverCancer #LiverCare #PharmaResearch #DrugDevelopment

Clinical trial participants often require regular monitoring to assess drug efficacy, but frequent blood draws can reduce compliance and increase participant discomfort. Invasive testing can discourage participants from staying in clinical trials, potentially compromising the quality and quantity of the data collected. Metabolic Solutions’ breath tests are non-invasive and easily repeatable, making them ideal for clinical trials requiring regular, frequent assessments.   Our tests provide high-quality data without causing discomfort, helping ensure participant retention and data integrity. Learn more at https://lnkd.in/er_X2ub6 #LiverHealth #LiverDiseaseResearch #NASH #ClinicalTrials #LiverCancer #LiverCare #PharmaResearch

Excited for the next steps in the evolution of Metabolic Solutions! Join us as we scale up the use of stable isotopes and mass spectrometry in drug development and disease diagnosis.

Dysregulation of de novo lipogenesis is a major factor in diseases like obesity, diabetes, and non-alcoholic fatty liver disease, yet researchers may struggle to accurately measure lipid synthesis and related pathway dynamics. Understanding this is a key component to identifying how metabolic diseases develop and progress. Without precise, reliable data on de novo lipogenesis, researchers are left with incomplete insights into processes that contribute to disease states like MASLD/MASH and metabolic syndrome. Incomplete data can make it difficult to pinpoint therapeutic targets or understand disease progression… …and how can you develop effective interventions if you’re not fully capturing data on the biochemical processes driving these diseases? To help with this, we offer de novo lipogenesis analytical services using carbon-13 and deuterium stable isotope methods. Our advanced techniques, including Mass Isotopomer Distribution Analysis (MIDA), provide precise measurements of lipid synthesis, allowing you to track the incorporation of 13C-acetate or deuterium labeling into plasma or hepatic triglycerides. With MetSol, you’ll get the data you need to unlock new insights into lipid pathways and advance your metabolic disease research. https://lnkd.in/eJNwGjD6 #ClinicalTrialsInnovation #LiverFunctionTesting #PharmaResearch #BiomarkerAnalysis #RealTimeData #LiverHealthMatters #MetabolicFlux

Pharmaceutical researchers: how do you measure liver dysfunction? Standard liver blood tests lack the specificity to determine the exact metabolic or enzymatic dysfunction in the liver. Without dynamic data, your trials may suffer from ambiguous results and inefficiencies. Traditional blood tests give you static data… … but this can leave you in the dark about which specific pathways are compromised.  This is like searching for a needle in a haystack—are the mitochondria underperforming, or is the microsomal or cytosolic function impaired? Without understanding metabolic flux, you could be forced to make assumptions, often leading to inaccurate trial outcomes or misguided adjustments to treatment protocols. Every day spent relying on unclear data increases trial costs, delays your research, and risks exposing patients to ineffective therapies. And if you can’t pinpoint changes in metabolic fluxes, how can you be sure your drug is working as intended? The consequences of incomplete data can be devastating, especially when it comes to advancing new liver therapies. Our breath tests offer a breakthrough solution. Our Methionine Breath Test measures mitochondrial activity, the Methacetin Breath Test determines microsomal function while our Phenylalanine Breath Test focuses on cytosolic function. Check out our breath tests for measuring liver function and learn how you can get real-time insights and optimize your trials for success. https://lnkd.in/er_X2ub6 #ClinicalTrialsInnovation #LiverFunctionTesting #PharmaResearch  #BiomarkerAnalysis #RealTimeData #LiverHealthMatters #PrecisionMedicine #BetterLiverTherapies

Current liver therapy trials use outdated static biomarkers. Most trials rely on blood tests that don’t measure liver function. These tests only offer a static glimpse of a much bigger picture. They only show one point in time and do not measure any specific metabolic function. But liver metabolic function is dynamic—and if you’re not tracking changes in metabolic function, you’re missing critical information. How are you supposed to assess your therapy’s actual impact if you can’t see the liver’s metabolic responses over time? This is like evaluating a marathon runner by looking at a photo of their performance during just one lap. There are no indications of the runner’s actual performance. Traditional liver tests fail to give you insight into ongoing metabolic processes, leaving you with incomplete, and potentially misleading data. Every trial, every patient, every decision you make with incomplete information is a risk. What if you’re missing out on crucial shifts in liver function that could impact your trial outcomes? Don’t let incomplete data slow down your progress or impact your results. Our liver function breath tests provide the real-time, dynamic data you need. By tracking ongoing mitochondrial, microsomal, and cytosolic functions, our breath tests capture the full metabolic picture, ensuring you never miss a critical change in liver health again. Check out our breath tests for measuring liver function and learn how you can get real-time insights and optimize your trials for success. https://lnkd.in/er_X2ub6 #ClinicalTrialsInnovation #LiverFunctionTesting #PharmaResearch #BiomarkerAnalysis #RealTimeData #LiverHealthMatters #PrecisionMedicine #BetterLiverTherapies

At Metabolic Solutions, we offer analytical services to measure dynamic fractional synthesis rates of collagen in liver, lung, and skin tissue. Our services include full preparation of tissue hydrolysis and determination of collagen (hydroxyproline) concentration. Collagen is an extracellular matrix protein that accumulates in tissues during normal wound repair and from chronic exposure to toxicants and irritants. Check out the link below to see more about the fibrosis/collagen turnover services we offer!

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At Metabolic Solutions, we continue to help researchers study de novo lipogenesis and lipid kinetics using carbon-13 and deuterium stable isotope methods. De novo lipogenesis is a complex regulated process in which circulating carbohydrates are converted to fatty acids. Dysregulation of de novo lipogenesis and lipid pathways is associated with obesity, diabetes, and non-alcoholic liver and cardiovascular diseases. If you are interested in our services, check out our website to see what we offer regarding de novo lipogenesis testing!

At Metabolic Solutions, we provide efficacy endpoint assays for rare disease and gene therapy treatment trials. Stable isotope tracers can be used in both pre-clinical and clinical studies to monitor specific biochemical pathways and provide evidence of restored enzyme activity. Check out this link to see the rare diseases we can monitor using our validated assays!