Molecular Instruments

We have exciting news to share! Molecular Instruments has won the UK lawsuit brought by Advanced Cell Diagnostics (a Bio-Techne group company), with the Court finding that two patents owned by Advanced Cell Diagnostics are invalid on obviousness grounds. Please see the press release linked below for more details. We look forward to continuing our mission to provide game-changing #onlywithHCR reagents to biologists, bioengineers, drug developers, and diagnostics developers worldwide. To learn more about our HCR™ imaging platform, check out our Automated Products (www.hcrimaging.com) and our Manual Products (https://lnkd.in/gJZePKk). https://lnkd.in/g_WfxEjF

This week’s #onlywithHCR Series stars Tetsuya Nakamura, a principal investigator at Rutgers University! Tetsuya appreciates #HCRimaging’s multiplexing capability, which allows him to confidently identify the colocalization of two signaling pathways at single-cell resolution. “The HCR™ platform completely transformed our lab projects. Despite such a simplified protocol, background noise is very low, providing beautiful staining. Moreover, the resolution of HCR™ RNA-FISH is exceptional, allowing us to observe RNA localization even inside a single cell.” Check out his remarkable image of a zebrafish pectoral fin below! 

We're excited to announce our upcoming joint webinar with Indica Labs on September 5th! We hope you join us as we dive into the world of HCR™ RNA-ISH assays and how they can be paired with HALO® image analysis for groundbreaking research. Our Business Development Manager, Michelle Saylor, will be presenting on the HCR™ platform, followed by a demo of HALO's powerful image analysis capabilities from Indica Labs' Sara Amirault. Register today at https://lnkd.in/g6N5g-PT! #HCRimaging #onlywithHCR #HALOimageAnalysis #IndicaLabs

This week’s Employee Spotlight welcomes our Operations Team’s father-son pup pair, Toby (all-white) and Milo Diaz! Toby, our resident alarm (he barks at everything), keeps us feeling safe and secure. On the other hand, Milo, his father, is the official office security inspector as nothing escapes his chompers.

This week’s #onlywithHCR Series highlights the Treen et al. (2023) publication, “An FGF timer for zygotic genome activation.” Treen et al. were able to develop a 4-plex #HCRimaging assay to verify their qPCR results in Ciona embryos. According to the authors, their 4-plex HCR RNA-FISH assay "was able to … reliably distinguish between cells that are actively transcribing genes and cells where the HCR in situ signal is exclusively cytoplasmic due to expression at earlier stages.” Check out their work here: https://lnkd.in/gg-Y3Yht. 

This week’s Employee Spotlight features Buster and Pat Wu, our Strategy Team’s beloved mascots! Their names were coined after Potemkin's character in the Guilty Gear Strive video game who has a famous HP move called Buster.

We're thrilled to attend this year's Society for Developmental Biology (SDB) Annual Meeting held in Atlanta, Georgia! Check out our posters (#354 & #355), and connect with our team at Booth #23. Our Chief Commercial Officer, Aneesh Acharya, Business Development Associate, Joseph Melko, and Associate Director of Marketing, Joyce Yoo, are excited to share MI's latest advancements in chromogenic and fluorescence ISH assays with you! For those not attending this year, discover how you can get started with HCR™ RNA-ISH with one of our complimentary Starter Kits by contacting us today. For more information, feel free to email our team at info@molecularinstruments.com or visit our website: https://lnkd.in/gJZePKk.

This week’s #onlywithHCR Series spotlights Timothy Tan, a PhD candidate in the Wu Lab at the University of Illinois Urbana-Champaign! Tim appreciates how “the HCR platform enabled [him] to visualize the cellular localization of RNA isoforms during viral infection.” Check out his stunning image below:

This week’s Employee Spotlight shines on Pucca and Pita Delgadillo, the Product Team’s eight-month-old Doberman sisters! Pucca prefers cuddles, leading you on playful chases to her favorite spots for affection. Meanwhile, Pita is the more outgoing sister, loving hugs and exploring new paths on their off-leash adventures.

This week’s #onlywithHCR Series highlights the Oh et al. (2024) publication, “Insights into digit evolution from a fate map study of the forearm using Chameleon, a new transgenic chicken line.” #HCRimaging enabled Oh et al. to examine the gene expression of SHH and PTCH1 in donor limbs after the presumptive ulna primordia grafts were excised to confirm that the grafted region was SHH-negative and PTCH1-positive. Check out their work in The Company of Biologists' Development Journal here: doi.org/m6jc