NanoImaging Services

We couldn’t agree more…. #cryoem #drugdiscovery

🚀 Cryo-EM is unlocking structures at an increasing speed. 🔬 Cryo-EM excels in structure determination of proteins, as well as capturing structural snapshots of molecules in different conformations or bound to ligands, providing valuable information about their functional states. 👀 See why #cryoEM is used more often than ever for #structuredetermination: https://lnkd.in/gSWyU3Ap

🤔 Do you know what your #liposomes & #LNPs look like? Cryo-TEM imaging allows you a first hand look at #liposomal formulations, including #lipidnanoparticles, drug encapsulated liposomes, and #micelles. 🔬 Quantitative analysis of #cryoTEM imaging studies provides data about #morphology, #payload, #lamellarity, and #blebbing, helps assess the impact of process changes, lot comparison, stability of formulations, release assays, and more. 👀 Learn more about phase appropriate characterization of lipid nanoformulations: https://lnkd.in/gSsbZFas

📑 In the paper “Structure of native HIV-1 cores and their interactions with IP6 and CypA” by Ni et al., researchers investigated the structure and interactions of the HIV-1 viral #capsid with host factors. 👨🔬 To overcome challenges in studying the native capsid, researchers utilized perfringolysin O (PFO) to perforate the membrane of #HIV-1 virus-like particles (#VLPs), enabling access to the capsid. 🔬 Using #singleparticle analysis, cryo-electron #tomography and #subtomogram averaging, the structures of native capsomers were determined in the presence and absence of inositol hexakisphosphate (IP6) and cyclophilin A (CypA). 👀 Read the paper and see the structures: https://lnkd.in/gU2gSEkC ➡️ Learn more how tomography can help reveal structures: https://lnkd.in/gt7nY5TM

🔬 Are you up to date on #cryoEM happenings at NIS? Scroll through our latest newsletter to catch up! 💡 Learn about our fully automated Empty:Full Analysis of #cryoTEM images for #AAV #capsids. 👩🔬 Check out our latest article about #GPCR characterization, with a focus on recent #GLP-1R structures.

💡 #GLP-1R drugs are a class of #GPCR drugs which have recently risen in popularity. 35 of the 50 GLP-1R structures currently deposited into the PDB were solved with #cryoEM. 🔬 Further, the majority of the cryo-EM structures are full-length GLP-1R in complex with the trimeric g-proteins and native ligands or potential drugs that bind to the orthosteric site as agonists to promote activation. 📓 Learn more in our newest blog: https://lnkd.in/gYDSQ6tY

💡 Stop by Booth 10 at the Gene Therapy Analytical Development & CMC Summit this week in Boston to learn about our fully automated full:empty analysis for #AAV! 🔬 Meet with Dr. Eric Bushong, Dr. Sarah Dunn, Ph.D., and Samantha Tipton to learn more about phase appropriate #cryoTEM imaging and analysis of #genedelivery vectors.

🧪 Will you be at the #TPD & #InducedProximity Summit this week in Boston? 👨🔬 Chat with Dr. Kenny (Gyunghoon) Kang, Dr. Sarah Strassler Sulley, PhD, and CCO Kristin Rider to learn about #cryoEM for structure determination of #proteindegraders including #PROTACs and #molecularglue. 🤝 Stop by booth 17, check out our poster, or book a meeting with us: https://lnkd.in/gVjNJ5Ev

National Chemistry Week is coming to an end and this year’s theme of “picture perfect chemistry” recognizes the vital role imaging plays in advancing scientific innovation. Did you know there are different types of chemical imaging needed to enable ground-breaking discoveries? Take a look at the Ampersand Capital Partners portfolio companies that are playing an important role in this field. NanoImaging Services Magritek Ltd Specac Ltd #NationalChemistryWeek https://lnkd.in/eYz4G-x6

🔬 🧪 GPCRs make up almost a third of drugs available on the market. Did you know 35 of the 50 #GPCR structures deposited in the PDB were solved by #cryoEM? 📑 Check out our latest article to learn about a structure based approach to GPCR elucidation: https://lnkd.in/gYDSQ6tY