Obesity Innovation Lab

Metaphore Biotechnologies: AI Meets Molecular Mimicry for Therapeutic Innovation Lovisa Afzelius, CEO of Metaphore Biotechnologies, shares the company’s approach to leveraging molecular mimicry to create novel therapies. By combining AI and biological insights, Metaphore aims to develop molecules that can mimic biological structures for therapeutic use. Flagship Pioneering, the company behind this venture, has a history of fostering groundbreaking scientific platforms, with a portfolio that includes Moderna, Sana Biotechnology, and Seres Therapeutics. #MolecularMimicry #AIinBiotech #FlagshipPioneering #TherapeuticInnovation #Biotechnology #ObesitySpace Credits: Lovisa Afzelius Metaphore Biotechnologies

Genes Influence Weight Loss Outcomes in Obesity, Study Finds A study by the University of Galway and Brunel University London has found that genetic differences influence how patients with severe obesity respond to a dietary weight-loss program. Using genetic risk scores related to obesity traits, researchers observed that individuals with a higher tendency for central fat retention experienced less weight loss. This insight could pave the way for more personalized obesity treatments in the future. #GeneticResearch #ObesityTreatment #WeightLoss #PersonalizedMedicine #HealthResearch #Future Credits: Brunel University of London Alex Blakemore Francis Finucane National University of Ireland Link to the complete article: https://lnkd.in/d-NyprvE

Australia's Obesity Crisis: Professor John Dixon's Concern Professor John Dixon from Iverson Health Research Institute warns that obesity in Australia is becoming increasingly common, with rising statistics leading to major health risks like heart disease, diabetes, and cancer. He emphasizes the need to rethink the causes of obesity and improve treatment options to address the issue effectively. Dixon highlights that obesity is a significant driver of disease in Australia and calls for a new approach to support those living with it. #ObesityCrisis #AustraliaHealth #PublicHealth #ObesityAwareness #healthrisks #futurism Credits: John Dixon Swinburne University of Technology

The Future of Obesity Treatment: Integrating Behavior Change with Tailored Medications Wondr Advanced is reshaping obesity management by combining behavior change support with personalized weight-loss medications. Led by Scott Paddock, the program partners with employers and health plans to reduce the costs and complexities of obesity treatment while improving overall health through a holistic, expert-guided approach. #ObesityManagement #WeightLoss #BehaviorChange #HealthcareInnovation #WondrHealth #EmployerHealth Credits: Scott Paddock Wondr Health

Innovative Microparticles Offer New Hope for Fat Reduction Using Bile Salts Researchers have developed stable microparticles using bile salts, such as cholate and deoxycholate, via a novel gold-templating method. These particles offer controlled release, effectively lysing fat cells in both in vitro and in vivo studies. Unlike current treatments like Kybella, this method minimizes side effects, opening up new possibilities for localized fat reduction therapies with enhanced safety and efficacy. #FatReduction #BileSalts #InnovativeTherapy #Microparticles #ObesityResearch Credits; AD/PD - Advances in Science & Therapy https://lnkd.in/dc73BSDS

Exploring Psychedelics for Obesity Treatment Clive Ward Able, MD, BPharm, discusses research into using psychedelic compounds, like psilocybin, to treat obesity. With two potential approaches, drug-enhanced psychotherapy and low-dose regimens, psilocybin may aid in controlling appetite and promoting well-being. While clinical trials are pending, pre-clinical studies on animals suggest potential for weight management. Ward Able highlights that this treatment aims to provide options for individuals seeking to achieve healthier weights and sustain long-term lifestyle changes. #PsychedelicMedicine #ObesityTreatment #Psilocybin #WeightManagement #HealthInnovation Credits: Dr. Clive Ward-Able NeonMind Biosciences

Potential New Anti-Obesity Treatment: Targeting miRNAs to Boost Energy Expenditure A recent study reveals that the drug enoxacin mitigates diet-induced obesity in mice by increasing energy expenditure and promoting oxidative metabolism in adipocytes. The mechanism involves enhanced FGF21 signaling and downregulation of miR-34a-5p, leading to higher expression of UCP1 and Ppargc1a. This breakthrough suggests a promising new class of anti-obesity drugs by targeting miRNA biogenesis, providing hope for future metabolic disease treatments. #ObesityResearch #EnergyExpenditure #miRNA #Enoxacin #Thermogenesis #FGF21 #Metabolism Credits: American Association for the Advancement of Science

Kickstart Your Weight Loss Journey with Allurion's Revolutionary Gastric Balloon The Allurion program offers a non-invasive weight loss solution with its innovative gastric balloon, requiring no surgery, endoscopy, or anesthesia. This balloon helps users feel fuller and eat less, leading to an average 10-15% weight loss over 16 weeks. With digital tools and support from a healthcare team, participants adopt sustainable lifestyle changes for long-term weight management. #GastricBalloon #WeightLossJourney #HealthyLiving #SustainableWeightLoss Credits: Allurion Technologies

Understanding Weight Loss Plateaus: Causes and Solutions Weight loss plateaus occur when energy expenditure equals energy intake, leading to stalled progress despite continued exercise. This happens because a lower body weight reduces the basal metabolic rate (BMR), decreasing total energy expenditure. To overcome plateaus, individuals can either reduce calorie intake or increase exercise intensity, frequency, or duration to maintain a negative energy balance. Quitting exercise or increasing calorie intake leads to weight regain. #WeightLossPlateau #EnergyBalance #ExerciseScience #HealthyLiving #Metabolism Credits: Jaime Ponce, MD Betty Burney American Society For Metabolic And Bariatric Surgery (ASMBS)

Global Obesity Crisis Needs Smart Food Policies, Experts Urge In response to the global obesity epidemic, experts from Harvard and The Lancet call for "smart food policies" that address both individual responsibility and unhealthy food environments. The authors advocate for comprehensive action using the NOURISHING framework, which includes food environment reforms, supply-chain incentives, and public health campaigns. They highlight the urgent need for collaboration between governments, industry, and society to reverse the obesity trend, especially in children. #ObesityCrisis #PublicHealth #HealthyEating #FoodPolicy #Nutrition Credits: Christina Roberto Kelly Brownell