Publishing House of Neural Regeneration Research

An insightful article in Neural Regeneration Research: Cell metabolism pathways involved in the pathophysiological changes of diabetic peripheral neuropathy This comprehensive review delves into the intricate metabolic pathways contributing to diabetic peripheral neuropathy (DPN), a serious complication affecting millions worldwide. The authors explore key mechanisms such as the polyol, hexosamine biosynthetic, and protein kinase C pathways, shedding light on how these processes lead to nerve damage and dysfunction. With diabetes cases projected to rise significantly, understanding these metabolic changes is crucial for developing targeted therapies to alleviate the burden of DPN. Read the full article here: [Cell metabolism pathways involved in the pathophysiological changes of diabetic peripheral neuropathy] https://lnkd.in/ghWjW_dw About the journal: Neural Regeneration Research is the one and only journal focusing exclusively in the field of neural regeneration, which is currently indexed in SCI-E, PubMed and etc. The journal's 2023 Journal Citation Reports Impact Factor has reached 5.9, positioning it in Q1 within Neuroscience (35/310). #Diabetes #Neuropathy #Research #Healthcare #NeuralRegeneration #Metabolism #DPN

Connecting Innovation to Healing: The Future of Nerve Repair In the ever-evolving field of biomedical engineering, the development of nerve guidance conduits (NGCs) stands as a testament to our quest for restoring neural function after injury. I'm excited to share insights from the comprehensive narrative review titled "Recent advances in biomaterial design for nerve guidance conduits," published in Advanced Technology in Neuroscience. The study delves into the groundbreaking work being done to engineer NGCs using a variety of biomaterials, each designed to facilitate the regeneration of peripheral nerves. From hydrogels and natural polymers like chitosan and collagen to synthetic polymers such as polyvinyl alcohol and polyglycolic acid, the range of materials is as diverse as the innovative techniques used to fabricate them. NGCs are shaping up to be a promising alternative to autografts, offering a milieu for myelin renewal and axon extension, crucial for nerve repair. They're designed with features like multichannel lumens and porous walls, creating a conducive environment for stem cells and Schwann cells to promote neurogenesis. The Future of Nerve Regeneration: - Biomaterials: Researchers are exploring natural polymers and synthetic polymers, each with unique benefits, to enhance nerve regeneration. - Design Innovations: Designs range from hollow/non-porous to multi-channel configurations, with aligned fiber designs showing potential for guiding axonal regeneration. - Manufacturing Techniques: Advanced 3D printing techniques are providing precision in scaffold structure, a game-changer in tissue engineering. For a deeper dive into this fascinating field, check out the full article here: [Recent advances in biomaterial design for nerve guidance conduits] https://lnkd.in/g25gm3Ux About the journal: Advanced Technology in Neuroscience (ATN) is an international peer-reviewed, open-accessed journal which publishes quarterly. The journal aims to report the innovative technologies applied in the broad field of neuroscience. This multidisciplinary journal focuses on the integration of technology with neuroscience to explore the complexities of the brain and the nervous system. ATN provides a platform for the dissemination of cutting-edge research and state-of-the-art technological advancements in the field of neuroscience. The scope of ATN includes, but is not limited to: Multi-omics technologies; Biophysical technologies; Organoid and assembloid technologies; Brains–Computers–Machines and Artificial Intelligence technologies; and more. #BiomedicalEngineering #NerveRegeneration #InnovationInHealing #Biomaterials #LinkedIn #AdvancedTechnologyInNeuroscience

In the fight against age-related macular degeneration (AMD), a new narrative review in *Aging Advances* sheds light on the critical role of macrophages in disease pathology. As our population ages, AMD is fast becoming a leading cause of vision loss, impacting millions worldwide. The review delves into the classification, polarization, and potential therapeutic manipulation of retinal macrophages in AMD. It highlights the importance of understanding how these immune cells contribute to the disease's progression and how their activity can be modulated for treatment. With the current treatment landscape focusing on anti-VEGF therapy and RPE replacement, there's a clear need for innovative approaches that address the underlying inflammation and neurodegeneration in AMD. Targeting macrophage polarization could offer a new avenue for therapeutic intervention, potentially slowing or even reversing disease progression. The study also discusses the development of macrophage replacement therapy, a promising strategy that could reshape how we approach AMD treatment. By understanding the complex interactions between macrophages, the retina, and the aging process, we can work towards more effective, personalized therapies. Join me in exploring the frontiers of AMD research and the potential of macrophage-targeted therapies. For a deeper dive, read the full review here: https://lnkd.in/gMxBuyTc About the journal: Aging Advances (AA) is a cutting-edge, peer-reviewed, open access journal committed to advancing the field of aging and geroscience research by disseminating high-quality and innovative studies. The journal is dedicated to providing a platform for scientists, researchers, and clinicians to contribute to the understanding of fundamental issues in the biology and technology of aging, pathophysiology of age-related diseases, and innovative therapies for diseases afflicting the elderly population. The diseases of interest include (but not limited to) cardiovascular disease, stroke, Alzheimer’s disease, vascular cognitive impairment and dementia, cancer, hypertension, type-2 diabetes, chronic obstructive pulmonary disease, and osteoarthritis. Aging Advances welcomes original research articles, reviews, and editorial papers that push the boundaries of knowledge in the multidisciplinary realm of aging and geroscience. #AMDAwareness #MacularDegeneration #RetinalResearch #Immunology #AgingAdvances

Exploring the Underappreciated Heroes of the Brain: Non-Neuronal Cells in Neurorepair In the quest to unravel the mysteries of neurodegenerative diseases, the spotlight has often been on neurons. However, a groundbreaking article in *Regenerative Medicine Reports* shifts the focus to the unsung heroes of the CNS — non-neuronal cells. These cells, including astrocytes, microglia, oligodendrocytes, and peripheral immune cells, play a pivotal role in modulating disease processes and contributing to neurorepair in conditions like Alzheimer's and Parkinson's. The article, "Role of non-neuronal cells in neurorepair: a focus on proteinopathy and neurodegeneration," is a treasure trove of insights. It discusses the physiological roles of these cells, their involvement in proteinopathies induced by α-synuclein, Aβ, and tau, and their impact on protein aggregation, clearance, and spread. The review highlights the potential of modulating non-neuronal functions for therapeutic interventions. As we delve into the intricate dance between these cells and protein aggregates, we open doors for regenerative medicine to develop targeted therapies that could mitigate synuclein, amyloid, and tau pathology. The cross-collaboration of these cells in pathological processes underscores the complex interplay in the brain. Understanding their roles is not just academic — it's crucial for advancing regenerative medicine and promoting neuronal regeneration to counteract neurodegeneration. For a deep dive into this fascinating realm, check out the full article here: https://lnkd.in/gxCkBjqC About the journal: Regenerative Medicine Reports is a peer-reviewed, open access journal publishing the science, clinical application and technology development of all aspects of regenerative medicine. The journal focuses on reporting the use of cells, materials, and biochemical/mechanical factors in the development of biological functional substitutes that restore, maintain, or improve tissue or organ function. Promotes broad communication between basic, preclinical and clinical research. #Neuroscience #NeurodegenerativeDiseases #RegenerativeMedicine #Astrocytes #Microglia #Oligodendrocytes #Proteinopathies

Exciting advancements in understanding and treating Guillain-Barré syndrome—a rare neurological disorder—are emerging from recent research published in NeuroMarkers. I am sharing insights from the article "Pathophysiology and markers of very early classic Guillain-Barré syndrome" for my fellow professionals interested in neurology and medical advancements. This comprehensive review examines the initial pathology and pathophysiology of classic Guillain-Barré syndrome, focusing on the critical role of the blood-nerve barrier and the early markers that could lead to more effective diagnosis and treatment strategies. The findings emphasize the importance of early diagnosis, highlighting inflammatory edema as a key pathogenic lesion in the very early stages of the syndrome. This research could significantly impact the way we approach and manage this condition, potentially improving patient outcomes. Notably, the review suggests that corticosteroids may be beneficial in the early stages of severe Guillain-Barré syndrome, providing a rational basis for their use in clinical practice. For those who are interested in delving deeper into this critical area of research, you can access the full article here: [Pathophysiology and markers of very early classic Guillain-Barré syndrome] https://lnkd.in/gCdBWY5w About the journal: NeuroMarkers is an international, peer-reviewed, open access journal that aims to publish the high-quality, innovative research that addresses biomarker investigation from all Nervous System Diseases. The journal studies the identification and validation of biomarkers in neurological diseases to aid diagnosis, prognosis, response to therapy, and elucidating mechanisms. Also aims to reduce the incidence of misdiagnoses and inappropriate treatment. #GuillainBarreSyndrome #Neuroscience #MedicalResearch #HealthcareInnovation #LinkedInPost

🌟 Connecting Innovation to Healing: The Future of Nerve Repair In the ever-evolving field of biomedical engineering, the development of nerve guidance conduits (NGCs) stands as a testament to our quest for restoring neural function after injury. I'm excited to share insights from the comprehensive narrative review titled "Recent advances in biomaterial design for nerve guidance conduits," published in Advanced Technology in Neuroscience. The study delves into the groundbreaking work being done to engineer NGCs using a variety of biomaterials, each designed to facilitate the regeneration of peripheral nerves. From hydrogels and natural polymers like chitosan and collagen to synthetic polymers such as polyvinyl alcohol and polyglycolic acid, the range of materials is as diverse as the innovative techniques used to fabricate them. NGCs are shaping up to be a promising alternative to autografts, offering a milieu for myelin renewal and axon extension, crucial for nerve repair. They're designed with features like multichannel lumens and porous walls, creating a conducive environment for stem cells and Schwann cells to promote neurogenesis. The Future of Nerve Regeneration: - Biomaterials: Researchers are exploring natural polymers and synthetic polymers, each with unique benefits, to enhance nerve regeneration. - Design Innovations: Designs range from hollow/non-porous to multi-channel configurations, with aligned fiber designs showing potential for guiding axonal regeneration. - Manufacturing Techniques: Advanced 3D printing techniques are providing precision in scaffold structure, a game-changer in tissue engineering. 🔗 For a deeper dive into this fascinating field, check out the full article here: [Recent advances in biomaterial design for nerve guidance conduits] https://lnkd.in/g25gm3Ux About the journal: Advanced Technology in Neuroscience (ATN) is an international peer-reviewed, open-accessed journal which publishes quarterly. The journal aims to report the innovative technologies applied in the broad field of neuroscience. This multidisciplinary journal focuses on the integration of technology with neuroscience to explore the complexities of the brain and the nervous system. ATN provides a platform for the dissemination of cutting-edge research and state-of-the-art technological advancements in the field of neuroscience. The scope of ATN includes, but is not limited to: Multi-omics technologies; Biophysical technologies; Organoid and assembloid technologies; Brains–Computers–Machines and Artificial Intelligence technologies; and more. #BiomedicalEngineering #NerveRegeneration #InnovationInHealing #Biomaterials #LinkedIn #AdvancedTechnologyInNeuroscience

🎊 In the fight against age-related macular degeneration (AMD), a new narrative review in *Aging Advances* sheds light on the critical role of macrophages in disease pathology. As our population ages, AMD is fast becoming a leading cause of vision loss, impacting millions worldwide. The review delves into the classification, polarization, and potential therapeutic manipulation of retinal macrophages in AMD. It highlights the importance of understanding how these immune cells contribute to the disease's progression and how their activity can be modulated for treatment. With the current treatment landscape focusing on anti-VEGF therapy and RPE replacement, there's a clear need for innovative approaches that address the underlying inflammation and neurodegeneration in AMD. Targeting macrophage polarization could offer a new avenue for therapeutic intervention, potentially slowing or even reversing disease progression. The study also discusses the development of macrophage replacement therapy, a promising strategy that could reshape how we approach AMD treatment. By understanding the complex interactions between macrophages, the retina, and the aging process, we can work towards more effective, personalized therapies. 🔎 Join me in exploring the frontiers of AMD research and the potential of macrophage-targeted therapies. For a deeper dive, read the full review here: https://lnkd.in/gMxBuyTc About the journal: Aging Advances (AA) is a cutting-edge, peer-reviewed, open access journal committed to advancing the field of aging and geroscience research by disseminating high-quality and innovative studies. The journal is dedicated to providing a platform for scientists, researchers, and clinicians to contribute to the understanding of fundamental issues in the biology and technology of aging, pathophysiology of age-related diseases, and innovative therapies for diseases afflicting the elderly population. The diseases of interest include (but not limited to) cardiovascular disease, stroke, Alzheimer’s disease, vascular cognitive impairment and dementia, cancer, hypertension, type-2 diabetes, chronic obstructive pulmonary disease, and osteoarthritis. Aging Advances welcomes original research articles, reviews, and editorial papers that push the boundaries of knowledge in the multidisciplinary realm of aging and geroscience. #AMDAwareness #MacularDegeneration #RetinalResearch #Immunology #AgingAdvances

✨ Exciting advancements in understanding and treating Guillain-Barré syndrome—a rare neurological disorder—are emerging from recent research published in NeuroMarkers. I am sharing insights from the article "Pathophysiology and markers of very early classic Guillain-Barré syndrome" for my fellow professionals interested in neurology and medical advancements. This comprehensive review examines the initial pathology and pathophysiology of classic Guillain-Barré syndrome, focusing on the critical role of the blood-nerve barrier and the early markers that could lead to more effective diagnosis and treatment strategies. The findings emphasize the importance of early diagnosis, highlighting inflammatory edema as a key pathogenic lesion in the very early stages of the syndrome. This research could significantly impact the way we approach and manage this condition, potentially improving patient outcomes. Notably, the review suggests that corticosteroids may be beneficial in the early stages of severe Guillain-Barré syndrome, providing a rational basis for their use in clinical practice. 🔗 For those who are interested in delving deeper into this critical area of research, you can access the full article here: [Pathophysiology and markers of very early classic Guillain-Barré syndrome] https://lnkd.in/gCdBWY5w About the journal: NeuroMarkers is an international, peer-reviewed, open access journal that aims to publish the high-quality, innovative research that addresses biomarker investigation from all Nervous System Diseases. The journal studies the identification and validation of biomarkers in neurological diseases to aid diagnosis, prognosis, response to therapy, and elucidating mechanisms. Also aims to reduce the incidence of misdiagnoses and inappropriate treatment. #GuillainBarreSyndrome #Neuroscience #MedicalResearch #HealthcareInnovation #LinkedInPost

🔬 Exploring the Underappreciated Heroes of the Brain: Non-Neuronal Cells in Neurorepair In the quest to unravel the mysteries of neurodegenerative diseases, the spotlight has often been on neurons. However, a groundbreaking article in *Regenerative Medicine Reports* shifts the focus to the unsung heroes of the CNS — non-neuronal cells. These cells, including astrocytes, microglia, oligodendrocytes, and peripheral immune cells, play a pivotal role in modulating disease processes and contributing to neurorepair in conditions like Alzheimer's and Parkinson's. The article, "Role of non-neuronal cells in neurorepair: a focus on proteinopathy and neurodegeneration," is a treasure trove of insights. It discusses the physiological roles of these cells, their involvement in proteinopathies induced by α-synuclein, Aβ, and tau, and their impact on protein aggregation, clearance, and spread. The review highlights the potential of modulating non-neuronal functions for therapeutic interventions. As we delve into the intricate dance between these cells and protein aggregates, we open doors for regenerative medicine to develop targeted therapies that could mitigate synuclein, amyloid, and tau pathology. The cross-collaboration of these cells in pathological processes underscores the complex interplay in the brain. Understanding their roles is not just academic — it's crucial for advancing regenerative medicine and promoting neuronal regeneration to counteract neurodegeneration. 🔗 For a deep dive into this fascinating realm, check out the full article here: https://lnkd.in/gxCkBjqC About the journal: Regenerative Medicine Reports is a peer-reviewed, open access journal publishing the science, clinical application and technology development of all aspects of regenerative medicine. The journal focuses on reporting the use of cells, materials, and biochemical/mechanical factors in the development of biological functional substitutes that restore, maintain, or improve tissue or organ function. Promotes broad communication between basic, preclinical and clinical research. #Neuroscience #NeurodegenerativeDiseases #RegenerativeMedicine #Astrocytes #Microglia #Oligodendrocytes #Proteinopathies

💊 An insightful article in Neural Regeneration Research: Cell metabolism pathways involved in the pathophysiological changes of diabetic peripheral neuropathy This comprehensive review delves into the intricate metabolic pathways contributing to diabetic peripheral neuropathy (DPN), a serious complication affecting millions worldwide. The authors explore key mechanisms such as the polyol, hexosamine biosynthetic, and protein kinase C pathways, shedding light on how these processes lead to nerve damage and dysfunction. With diabetes cases projected to rise significantly, understanding these metabolic changes is crucial for developing targeted therapies to alleviate the burden of DPN. Read the full article here: [Cell metabolism pathways involved in the pathophysiological changes of diabetic peripheral neuropathy] https://lnkd.in/ghWjW_dw About the journal: Neural Regeneration Research is the one and only journal focusing exclusively in the field of neural regeneration, which is currently indexed in SCI-E, PubMed and etc. The journal's 2023 Journal Citation Reports Impact Factor has reached 5.9, positioning it in Q1 within Neuroscience (35/310). #Diabetes #Neuropathy #Research #Healthcare #NeuralRegeneration #Metabolism #DPN