Research Institute for Fragrance Materials, Inc. (RIFM)

The RIFM Database: Everything you need—at your fingertips Register: https://lnkd.in/enpcVCSZ Whether you’re a current subscriber or are curious about what the RIFM Database can do for you, join us on Wednesday, May 22, from 8:30 AM to 10:00 AM EDT, to learn how to unleash the full power of the RIFM Database. This in-depth overview includes spotlights on: Discrete Chemicals  Natural Complex Substances (NCS) Chemical Clustering Exclusive Data Summaries and Tools Fragrance safety begins here. About the RIFM Database The RIFM Database is the most comprehensive, worldwide source of toxicology data, literature, and general information on fragrance and flavor raw materials. With more than 80,000 references that include approximately 200,000 human health and environmental studies, the RIFM Database also houses several tools critical to RIFM’s Fragrance Ingredient Safety Assessment and Research programs.

The Research Institute for Fragrance Materials (RIFM) announces public introduction to the world’s largest fragrance ingredient database Register for the free online May 22nd event at: https://lnkd.in/enpcVCSZ Read more about the event: https://lnkd.in/ec_h43Bt

The Research Institute for Fragrance Materials’ Senior Scientist for Dermatotoxicology, Isabelle Lee, PhD, will participate at the Household & Commercial Products Association's 2024 Mid-Year Meeting May 7-10th in Washington, DC. Dr. Lee leads the skin sensitization endpoint at RIFM in conducting safety assessments and research projects. Dr. Lee will participate in the Joint Air Care & Cleaning Products Division Program to present the findings of RIFM’s recently peer-reviewed and published low-exposure paper. Dr. Lee served as lead author of the paper. Read the story at https://lnkd.in/ehRKvDT4

The Research Institute for Fragrance Materials’ Principal Scientist for Environmental Toxicology, Aurelia Lapczynski, will participate at the #SETAC Europe 34th Annual Meeting in Seville, Spain, May 5 – 9, 2024. Lapczynski’s participation includes a RIFM-co-funded workshop, Green Deal Safe and Sustainability by Design, and two posters. Get the full story at https://lnkd.in/ekiN8_bG

The Research Institute for Fragrance Materials’ Senior Scientist for Chemistry and Genotoxicity Holger Moustakas, PhD, will participate at the International Union of Toxicology’s XII Congress of Toxicology in Developing Countries in Santiago, Chile, April 15–18, 2024. Dr. Moustakas will share RIFM’s cutting-edge science in two forms: a live presentation (“Use of New Approach Methodologies (NAMs) for Genotoxicity Safety Assessment”) and a poster (“Development and Application of Structural Activity Groups for Chemical Classification and Clustering as a Non-animal Method for Safety Assessment”). Read the full story: https://lnkd.in/eRbddprJ

A paper showing that exposure to fragrance ingredients is extremely low wins coveted Society of Toxicology award: Fragrance ingredient exposure and risk assessment highlighted at the year’s biggest toxicology conference. Congratulations to Isabelle Lee, PhD, Anne Marie Api, PhD, Brendan Ring, Cronan McNamara, and colleagues. Read the story at https://lnkd.in/e2RByGSN

Scientists from the Research Institute for Fragrance Materials (RIFM) will participate at the Society of Toxicology’s 63rd Annual Meeting and ToxExpo in Salt Lake City, Utah, March 10–14, 2024. The annual conference draws over 5,000 attendees. https://lnkd.in/gCdW6cVX RIFM researchers will share their knowledge and experience and advance their science through continuing education courses, poster presentations, workshops, panels, and special ancillary sessions throughout the five-day conference. Several RIFM scientists will attend this critical meeting, presenting recent research that RIFM has performed in collaboration with fragrance safety stakeholders. Additionally, RIFM scientists will join Creme Global’s data scientists at a special ancillary session highlighting RIFM and Creme’s work on the Creme-RIFM Aggregate Exposure Model. We look forward to sharing some ongoing research detailed below with the larger toxicology community in March.

Fragrance ingredient exposure is orders of magnitude below thresholds of concern, study shows A paper published in Regulatory Toxicology and Pharmacology reveals consumer exposure to fragrance to be extremely low The Research Institute for Fragrance Materials, Inc. (RIFM), in collaboration with scientific modeling, data analytics, and computing company Creme Global, compared the fragrance exposure of the highest-end product users to the Threshold of Toxicological Concern (TTC) and Dermal Sensitization Threshold (DST) to determine a realistic understanding of consumer exposure to fragrance. The TTC is based on the U.S. Food and Drug Administration’s Threshold of Regulation, which it expands upon to include consideration of an ingredient’s molecular structure in conjunction with its toxicity data. The TTC approach is internationally recognized by regulators including the European Food Safety Authority (EFSA). The study authors compared exposure to the approximately 3,000 in-use fragrance-producing ingredients to their respective TTCs and DSTs. Representative fragrance ingredients were randomly selected and analyzed for exposure distribution by product type (i.e., personal, household, oral, and air care) and route of exposure. Exposure calculations were performed by the Creme-RIFM Aggregate Exposure model, which provides realistic exposure estimates that consider all fragrances the population is exposed to across all products used. (Read the published paper https://lnkd.in/ejV9vac8.) The study’s lead author, Isabelle Lee, Ph.D., Senior Scientist of Dermatotoxicology at RIFM, explained, “We found that 76% of fragrance-producing ingredients fall below their TTC levels when compared to the systemic exposure experienced by the highest-end users, while 99% of fragrance ingredients are below inhalation exposure TTC levels.” Paper co-author Anne Marie Api, PhD, RIFM’s president, explained, “It may seem there is a lot of an ingredient in a product because our nose tells us it’s there. But our olfactory sense is far better than most realize. We can easily detect something at concentrations of parts per million and, in many cases, parts per billion. Thus, very little fragrance is required to impart a desired scent.”   About RIFM RIFM assesses the safety of fragrance ingredients by the most current, internationally accepted guidelines—and has done so since its founding in 1966. RIFM’s peer-reviewed safety assessments and research are free to the public via https://lnkd.in/enPQy8TA.   Media Contact: The Research Institute for Fragrance Materials, Inc. (RIFM) Gary Sullivan Marketing & Communications Manager gsullivan@rifm.org

RIFM’s second virtual Annual Science Symposium is only two days away! WHEN: November 29, 2023, 8:00 AM – 12:00 PM (noon) EST WHERE: https://lnkd.in/exzFM-Fk Use “RIFM” (without quotes) if prompted for code. During this four-hour, multi-track symposium, RIFM’s scientists will highlight recently published and ongoing research that will significantly impact the future of the science supporting fragrance safety. In addition, RIFM’s staff will provide details and answer your questions about its internationally recognized safety assessment program. Some of the science we plan to highlight includes: * The clustering of fragrance ingredients into similar safety profiles * Ensuring the safe use of Natural Complex Substances (NCS, or “Naturals”) * RIFM’s Environmental Framework 2.0 * New Approach Methodologies (NAMs) focusing on alternatives to animal testing “This year’s symposium will provide fragrance safety stakeholders worldwide the opportunity to meet and interact with RIFM scientists and staff as well as several of RIFM’s collaborators working to ensure that the world can safely enjoy their favorite fragranced products,” explained RIFM’s Safety Assessment Manager, Danielle Botelho, Ph.D. “Collaboration, strategy, and global solutions are the three keywords that drive this year’s event, setting the tone for a powerful discussion to shape the future of fragrance safety,” said RIFM President Anne Marie Api, Ph.D. “Everyone from those creating fragrances to regulators and consumers can ask questions and gain insights into the science supporting the safe use of fragranced products.” We’d love to see you on November 29th! Registration is now open at: https://lnkd.in/exzFM-Fk

Only two weeks until RIFM's biggest (free!) event. Register now for RIFM's 2nd Annual Science Symposium and meet and talk directly with our scientists on Wednesday, November 29th! https://lnkd.in/exzFM-Fk