The Alliance for Longevity Initiatives

We are thrilled to announce our latest groundbreaking research with Yale University. This first-of-its-kind study analyzed the impact of 51 longevity interventions–spanning diet, exercise, pharmacological, and therapeutic modifications–on multiple biological age clocks to identify which are most effective at slowing aging. Why it’s a big deal: 1.) This is the first meta-analysis of its kind. DNA methylation clocks were created to give us a measuring stick for aging that can be used in real time, so we don't have to wait 40+ years to see how interventions help patients. This is the first major head-to-head comparison of these tools. 2.) The study analyzes all the major DNAm clocks and establishes a new classification of “GenX Clocks”, which refer to a new class of explainable biological age clocks that offer more detailed, system-specific insights into how different parts of the body are aging, allowing users to track specific areas like metabolic, immune, or cardiovascular health. Our SymphonyAge and OMICmAge were classified as “GenX”. 3.) The best part? Not only was TruDiagnostic found to be the only company with explainable clocks, but also the results showed that the clocks we use are the most responsive for measuring interventional impact versus all other clocks. The Study: From diet and exercise to advanced medications, this study evaluated how different interventions impact your aging and how the DNAm clocks’s varied. Key Findings: Medications like metformin and anti-inflammatory treatments showed the strongest results for reducing biological age. Lifestyle choices—especially the Mediterranean diet—consistently improved health markers across multiple systems. Senolytic drugs (which target aging cells) were hit or miss, showing some potential but needing further research. Curious to know how you measure up? Try our TruAge biological age test today! Link Here - https://buff.ly/40tBYU9 Groundbreaking Yale and TruDiagnostic Study Compares 51 Interventions to Slow Aging Across Multiple Biological Clocks https://buff.ly/3NJzGZf

This week on A4LI’s H-SPAN Podcast, we sat down with Dr. George Sutphin, Assistant Professor of Molecular & Cellular Biology at the University of Arizona BIO5 Institute and Chairperson of AMERICAN AGING ASSOCIATION. In this episode, we discuss Dr. Sutphin’s journey from aerospace engineering to geroscience, his lab’s research into aging, and what he is most looking forward to in the field of longevity science. You can listen to our full discussion here: https://bit.ly/4f0aNEx 

A new Advanced Research Projects Agency for Health (ARPA-H) program aims to develop a tear-based biomarker measurement system that would allow continuous monitoring and ultra-precise personalized treatment. This new OCULAB project is targeting dry eye disease and, if successful, has the potential for more precise intentions for many other disorders.

Congratulations to our Scientific Advisory Board member, Jennifer Garrison, for placing first in the XPRIZE Global Visioneering Conclave! We look forward to championing women’s health and its impact on aging and healthspan with you!

Agingbiotech.info is an outstanding resource for anyone seeking to navigate and understand the rapidly evolving longevity field.

Congratulations, Rubedo Life Sciences!!

Congratulations to Life Biosciences for recently sharing greats news about ER-100, a novel partial epigenetics reprogramming gene therapy using the OSK transcription factors in treating optic neuropathies. The results they shared expanded on effective dosing and timing of treatment in nonhuman primates. Life Biosciences has plans to bring ER-100 into human clinical trials in the second half of 2025! Life Biosciences is a Boston-based biotech company with a mission to develop cellular rejuvenation therapies to reverse and prevent diseases of aging. In addition to their cellular rejuvenation pipeline, they are developing small molecules activators of chaperone-mediated autophagy – a cellular mechanism that increases recycling in our cells. Congratulations again, Life Biosciences! Here’s to redefining again! 

I look forward to speaking at this year's Longevity Summit! Thank you for the opportunity Longevity Global. If you are an A4LI member, you get 10% off your GA ticket! Support our mission and become a member today: https://lnkd.in/g7RcxBbg.

This week on A4LI’s Scientist Spotlight, we get to chat with Caitlyn Fastenau, a fifth year PhD student wrapping up her PhD work in neuroimmunology and neurodegeneration interactions at UT Health San Antonio. In this episode, we discuss what inspired her to pursue STEM, her passion aging research, science communication, and advocacy work. You can listen to our full discussion here: https://spoti.fi/3NuM7s0

The National Institute on Aging (NIA) National Advisory Council on Aging recently approved new concepts that could lead to future funding opportunities, fostering interdisciplinary research aimed at deepening our understanding of aging, taking advantage of recent technological advances and discoveries. Some of the approved concepts are: 𝗔𝗿𝘁𝗶𝗳𝗶𝗰𝗶𝗮𝗹 𝗜𝗻𝘁𝗲𝗹𝗹𝗶𝗴𝗲𝗻𝗰𝗲 𝗮𝗻𝗱 𝗧𝗲𝗰𝗵𝗻𝗼𝗹𝗼𝗴𝘆 𝗖𝗼𝗹𝗹𝗮𝗯𝗼𝗿𝗮𝘁𝗼𝗿𝘆 (𝗔𝗜𝗧𝗖) 𝗥𝗲𝗻𝗲𝘄𝗮𝗹  This concept expands the current AITC program and help meet the increasing demand for AITC resources and equitably address scientific priorities across NIA. The expansion will promote integration of experimental and AI/ML approaches to better understand mechanisms of aging, health monitoring technologies, imaging and image analysis, and clinical decisions support tools in personalized care.  𝗔𝗴𝗶𝗻𝗴 𝗠𝗮𝗺𝗺𝗮𝗹𝗶𝗮𝗻 𝗧𝗶𝘀𝘀𝘂𝗲𝘀 𝗜𝗻 𝗩𝗶𝘁𝗿𝗼  This concept will support the development of mammalian 3D in vitro tissue systems to model aging to gain insight into the biology of aging and as new tools for screening and testing geroprotectant interventions. 𝗕𝗮𝘁𝘀 𝗮𝗻𝗱 𝗛𝗲𝗮𝗹𝘁𝗵𝘆 𝗔𝗴𝗶𝗻𝗴   This concept will characterize and validate wild and captive bat populations as models for aging research. It aims to explore potential biological, physiological, sensory, behavioral, and social aging processes that contribute to longevity and healthspan in bats and to develop novel interventions for age-related disorders. 𝗥𝗡𝗔 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘀𝗺 𝗶𝗻 𝗔𝗴𝗶𝗻𝗴 𝗮𝗻𝗱 𝗔𝗴𝗶𝗻𝗴-𝗥𝗲𝗹𝗮𝘁𝗲𝗱 𝗗𝗶𝘀𝗲𝗮𝘀𝗲𝘀  RNA editing, alternative splicing, and RNA modification in the regulation of aging and longevity has been an area that remains highly unexplored. Recent technological advances, such as DNA and RNA sequencing, single cell and spatial omics technologies, offer new opportunities to investigate the intricate roles of RNA metabolism. 𝗠𝗼𝗱𝗲𝗹𝗶𝗻𝗴 𝗔𝗴𝗶𝗻𝗴 𝗧𝗵𝗿𝗼𝘂𝗴𝗵 𝗠𝗶𝗰𝗿𝗼𝗽𝗵𝘆𝘀𝗶𝗼𝗹𝗼𝗴𝗶𝗰𝗮𝗹 𝗦𝘆𝘀𝘁𝗲𝗺𝘀  Microphysiological systems (MPS) — in vitro, three-dimensional (3-D) constructs that mimic human tissue or organ functions — could provide relevant and cost-effective models to complement two-dimensional cell cultures and animal models. Current MPS on the market do not include an aging component. This concept invites small businesses currently to create self-contained systems that maintain 3-D tissue constructs to allow for human-relevant modeling of molecular and cellular aging processes and/or drug discovery for aging-related diseases. The MPS fabrication procedure should be cost-effective, mass-producible, modular, and robust to ensure successful commercialization. Check out the other approved concepts here: https://lnkd.in/g6wRRcSG