In-Vivo Pharmacology Associate Scientist/Scientist I

LOCATION **Long Island City, New York **

WHO WE ARE

Aethon Therapeutics creates neoantigens by design, to transform cancer treatments into cures. Aethon’s novel anti-drug-peptide conjugate/MHC (p*MHC) antibodies, engineered using the company’s proprietary HapImmune™ platform, are designed to be used in combination with targeted covalent inhibitors of RAS, EGFR, and other oncogenic driver mutations, to mount immune attacks to selectively kill residual cancer cells, including drug-resistant “persister” cells. Aethon unites immunotherapy and small molecule targeted therapy to expand the power and promise of both approaches for people living with cancer. For more information, visit www.aethontx.com. Aethon is funded by Apple Tree Partners (ATP), a leader in life sciences venture capital, with $2.65 billion in committed capital

POSITION SUMMARY

We are seeking an ambitious, curious, and detail-oriented scientist at the Senior Research Associate/Associate Scientist level to join Aethon’s growing team. Working closely with our other R&D scientists, you will help drive drug discovery and development efforts by designing and conducting experiments. This is an exciting opportunity to work with, and learn from, multidisciplinary teams in a small, fast-paced biotechnology company. The successful candidate should be able to work effectively in a team-oriented environment and is accustomed to delivering robust high-quality data on a timeline. A key part of this role will be to undertake in-vivo experiments in a vivarium that is located within the Alexandria Center for Life Science in Long Island City, NY, in close proximity to the Aethon Therapeutics laboratories.

KEY RESPONSIBILITIES

• Animal care and monitoring:
• Provide daily care and monitoring of mice, including health checks and documentation.
• Maintain detailed and accurate records of all procedures and animal health status; investigate adverse study events.
• Tumor implantations:
• Perform precise implantation or injection of tumor cells into mice to establish models for oncology studies.
• Monitor and document tumor growth and animal health.
• Dosing procedures:
• Administer compounds by all routes (i.v., i.p., s.q., p.o.) accurately and safely.
• Tissue harvesting:
• Collect blood, tumor tissue, and organs including spleen and lymph nodes for processing and analysis.
• Compliance and safety:
• Follow all institutional, local, and federal regulations regarding animal care and use.
• Adhere to safety protocols and maintain a clean and organized work environment.
• Meticulous electronic lab notebook documentation.
• In addition to the in-vivo pharmacology role, the successful applicant will have an opportunity to gain experience of all aspects of antibody engineering including phage and yeast display; immunopeptidomics and mass spectroscopy; flow cytometry and tissue culture.
• Communicate experimental plans and results to the leadership team.
• On-site work only, no hybrid or remote option.
• Occasional weekend or holiday work may be necessary depending on study needs. (This will be compensated separately).

SKILLS, QUALIFICATIONS AND EXPERIENCE

• Bachelor’s Degree in a relevant discipline (Veterinary Technology, biology, chemistry, animal sciences, or related field) and at least 3-5 years of experience or Master’s Degree and at least 2 years of relevant experience.
• At least 2 years of industry experience in a biotechnology/pharmaceutical company or full-time academic lab experience.
• Certification as a Veterinary Technician (CVT, LVT, or RVT) preferred.
• Expertise with oncology studies including experience with tumor cell implantations and compound dosing preferred.
• Knowledge and experience with formulation of small molecules and biologics.
• Experience culturing cell lines and/or primary immune cells is a plus.
• Strong verbal and written communication skills to effectively share scientific findings.
• Passion for working at the bench and in the vivarium to advance programs and solve technical challenges.
• Self-motivation and adaptability to evolving project priorities and responsibilities.
• Team-oriented, with a strong work ethic.
• Ability to learn new techniques for which training will be provided.

BENEFITS

We provide a vibrant startup environment where every employee contributes to our culture and science. We offer a generous total rewards plan that includes competitive salary, stock options, and benefits, as well as an opportunity for a performance-based bonus. The base salary range for this role is $115,000-$130,000 annually. Actual salaries depend on a variety of factors, including experience, specialty, and education.