Principal Scientist, Early Cancer Detection

ICR's Early Cancer Detection program is focused on building early warning systems out of arrays of blood- and urine-based biomarkers from cancer patients and healthy controls. We're using machine learning to predict cancer signatures to enable early intervention when cancer is most treatable. We're hiring a Principal Scientist to lead our Cancer Early Detection Team.

With ICR, you'll get to:

• Lead a cutting-edge cancer biomarkers group to detect cancer at its earliest stages
• Contribute highly practical and readily translatable pan-cancer screening/early detection, diagnostic, prevention and therapeutic ideas
• Quantify and track cancer biomarkers, including CTCs, cfDNA, serum, plasma, and urine proteins, RNA, metabolites, driver-gene mutations, epigenetic modifications, etc
• Collaborate with ICR's Biomarkers Team to perform molecular and cellular cancer prevention screening assays, under a personalized medicine paradigm

Please apply if you have:

• A PhD, MD or both
• At least 10 years of cancer research experience, preferably in early detection and biomarkers
• Current and in-depth knowledge of pan-cancer: screening, early detection, biomarkers, diagnostic prediction, genetics, prevention, and chemical- and vaccine-therapeutics (practical and experimental)
• Programming experience in R and Python
• Solid grasp of biostatistics, especially probability theory
• Experience with prediction modeling and machine learning, including experience using proper scoring rules

Ideally, you'll also have:

• Expert knowledge and understanding of worldwide pan-cancer drug development pipelines
• Experience with cell-based assays, immunofluorescent microscopy, qPCR, flow cytometry, single-cell genomics, RNAseq, cell culture, organoid culture, Illumina NextSeq 550, DNA methylation sequencing, ddPCR, Luminex, clinical chemistry instrumentation, Kryptor, Access 2, robotic liquid handling (e.g. Tecan), Vortex, and DepArray
• Knowledge and experience in cutting-edge paradigms of immuno-oncology including cell therapies, CAR-T, peptide vaccines, RNA vaccines, dendritic cell vaccines, neo-antigen vaccines, clinical vaccine safety, T cell and antibody analysis of vaccine-induced immunogenicity, etc
• Experience with protein, RNA, and small metabolite cancer biomarker analysis
• Knowledge of and experience with Kaggle competitions

And you'll need:

• An easygoing, friendly personality
• The ability to work in the United States without sponsorship

Position title and compensation are commensurate with experience.

The compensation ranges listed below are starting ranges.

Starting base pay range: $165,000/yr - $205,000/yr

Starting bonus range: $7,500/yr - $20,000/yr