LifeMine is a biopharmaceutical company pioneering Top-Down Drug Discovery™, a bold new approach that leverages evolutionary insights from fungi to unearth next-generation precision medicines. Through our data-immersive and technologically expansive discovery engine, we are uniquely positioned to bring mechanistically and structurally novel precision medicines to patients in urgent need of breakthrough disease intervention. LifeMine's initial pipeline programs are focused in organ transplantation and antifungals. The Company is headquartered in Cambridge, MA, with offices in Gloucester, MA and Basel, Switzerland.
What's the opportunity?
We are seeking a highly motivated Scientist to join our Discovery and Translational Biology team located in Cambridge, MA. The ideal candidate will have expertise in Immunology, focused on T-cell driven indications. This person should have extensive experience with flow cytometry, primary immune cell readouts and in vivo pharmacology to advance LifeMine's lifesaving drug Candidates into the clinic to better serve patients.
Job Responsibilities:
Propose study designs and conduct experiments to evaluate immunomodulatory response mechanisms in vitro and in vivo.
Diligently record, analyze, and present data to team members.
Facilitate in vivo pharmacology efforts with key CRO partners.
Collaborate across functional teams to efficiently contribute to IND-enabling studies.
Contribute to build a robust PK/PD/efficacy relationship and translational biomarker readouts to advance to the clinic.
70% Benchwork
What you'll need to be successful:
PhD in immunology or related field with 3+ years experience in academic, biotechnology or pharmaceutical industry.
Extensive experience with primary immune cells whole blood, PBMCs, immune cell subset enrichment and culture/co-culture methods.
Proficiency in immunological readouts e.g. MLR, Luminex, MSD, flow cytometry, ELISA.
Supporting vivo pharmacology efforts to characterize immunomodulatory efficacy in tissue derived immune cell infiltrates is a plus.
Ability to efficiently communicate research questions, propose experiments to deliver key data.
Excellent at problem solving and multitasking, with enthusiasm to continually seek avenues to synergize with and support team members.
Ability to work independently and thrives in a fast-paced team environment.
Our Culture DNA
Our success at LifeMine is rooted in our unique Culture DNA, shaping how we innovate, collaborate, and achieve our mission. These values drive us forward, pushing the boundaries of science and delivering transformative medicines.
Collective Genius
We thrive on our ability to think and act as force multipliers for each other, and our collective strength lies in our collaborative spirit and the unique talents of our diverse team. Together, we push the boundaries of science and technology to mine groundbreaking medicines.
Inquisitive Expeditioners
We are pioneers at heart, driven by relentless curiosity to explore uncharted territories in drug discovery, leveraging evolutionary insights from fungi to lead the journey of innovation.
Inspired Learners
We embody a culture of perpetual growth and curiosity, where learning, teaching each other, and innovation intersect. This commitment to exploration and education ensures we remain at the forefront of delivering sophisticated, precision medicines.
Medicine Miners
Mining for high-impact medicines is fundamental to our identity. Through our data-immersive and technologically expansive discovery engine, we bring sophisticated medicines to patients in urgent need. We're doing more than finding cures; we're securing a healthier future for humankind.
Seniority level
Mid-Senior level
Employment type
Full-time
Job function
Research, Analyst, and Information Technology
Industries
Technology, Information and Internet
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