23andMe’s Post

𝗕𝗿𝗲𝗮𝗸𝗶𝗻𝗴 𝗡𝗲𝘄𝘀! 🚨 5 Prime Sciences Partners with Eli Lilly and Company to Advance Cardio-Metabolic Disease Drug Development Through strategic collaboration they are devoted to accelerate discovery and early development in the field of cardio-metabolic diseases. "Under the terms of the agreement, 5 Prime Sciences will deploy its human genetics, multi-omics and AI technologies to identify and validate potential drug targets in cardio-metabolic diseases, including diabetes, obesity, and related conditions." Read more through the link in the comments below: #DrugDiscovery #Biotech #CDMO #MasonHarding

Don't let medication side effects keep you from living your best life. Discover how pharmacogenetic testing from genediagnostics.co.za can help you find the right medication for your unique genetic makeup. Pharmacogenetics is a once-off genetic test indicating how your genes (DNA) affect your body’s response to certain medication. It is a comprehensive test and includes input on the medication you are currently taking, and possible future prescriptions.   Order your test online today and get a 30% discount. Was R3550. Now only R2485. Use COUPON number 2023PHARM for your discount to apply. Terms & conditions:   Offer valid between 24 - 30 November 2023; and Online purchases only Order Now: https://lnkd.in/d4HrrsRS #Pharmacogenetics #MedicineScreening #PersonalizedMedicine #GeneticMedication #DrugResponse #BlackFridayMedicine #HealthcareInnovation #PharmaGenomics #BFDiscount #HealthOptimization #BF2023

🧬 Did you know that your genetics can influence how you respond to medication? That's where pharmacogenetics comes in! 🌟 Pharmacogenetics is all about understanding how variations in your genome can affect how your body reacts to drugs. It plays a crucial role in personalized medicine, which aims to tailor treatments to each individual's unique genetic makeup. 💊💡 By studying your genes, pharmacogenetics can help doctors determine which medications are most effective for you and even help avoid adverse side effects. It's like having a personalized prescription made just for you! 🩺💙 If you're curious about how pharmacogenetics works and want to learn more, check out our latest blog post. We delve into the fascinating world of genetic variations and drug response: https://lnkd.in/d-kPJiqV 📚✨ And if you're ready to take control of your health and find out which medications work best for you, why not consider getting a BioCertica Pharmacogenetic report? It's an investment in your well-being that could make a world of difference! 💪💊 #pharmacogenetics #personalizedmedicine #geneticsandhealth #tailoredtreatments #bioinformatics

Did you know... Our Drug Metabolism with PGx Comprehensive panel is available for order directly through our website? As a provider, you can log into our store and place an order for your patient in just minutes! You can also create an account with us and place bulk orders for kits to have conveniently at your office. Call us today to learn more about our readily available genetic tests, or visit our website for more information! #KashiClinicalLaboratories #Pharmacogenomics #PersonalizedMedicine #HealthcareInnovation #MedicalAdvancements #PrecisionMedicine #PatientCare #PGxTesting

This is a really nice paper on GLP-1 related drugs, if you missed it this summer, now is a good time to catchup. Many of us have seen GLP-1 in our genomic assays over the years, but it's what you know and do with a target that counts in order to produce a blockbuster. If you want to know your target well, you need to understand the literature and relevant omics data. We are in a unique position to help our customers with the knowledge of Biorelate Ltd.'s AI powered causal interactions combined with the most comprehensive platform for multi-omics data and analysis from Pythia Biosciences. Message me for a demo. https://lnkd.in/gTHU_jEX

This paper helps calm my nagging worry that maybe we've all been wrong about genetics and drug success. By looking at a completely new dimension of drug success/failure, they reaffirm the effect we have repeatedly seen using target-indication pair progression. I think this is really important. https://lnkd.in/g-fmtn7X

April 25th is National DNA Day! Did you know that your DNA plays a key role in how your body processes medications? Your genetics influence the production of Cytochrome P450 enzymes, which are responsible for metabolizing 70-80% of drugs. Variations in genes that code for these enzymes can lead to some people metabolizing medications too quickly or too slowly, impacting their effectiveness or potentially causing adverse side effects. It is estimated that more than 90% of the population carries at least one genetic variant that influences how medications are processed. Pharmacogenetic (PGx) testing can aid in identifying these variations and predicting your body’s response to medication. PGx testing empowers healthcare providers to: - Make informed decisions about the best drugs and dosage specific to YOU  - Reduce the risk of adverse side effects - Provide a more personalized level of care Celebrate National DNA Day by learning more about pharmacogenetics: https://lnkd.in/dvGDNfz #DNA #nationalDNAday #genetics #pgx #pharmacogenetics #pharmacogenomics

Obesity: will DIDO yield or become lost in translation? A PNAS paper from Thierry Fisher’s team from CNB-CSIC in Madrid (PMID: 38194457) shows a new role for the DIDO protein (Q9BTC0 · DIDO1_HUMAN) on diet induced obesity and suggests that drugging it may be a way to treat obesity or metabolic syndromes. This is a good illustration of the challenges facing the pharma industry with non enzymatic targets. Below is an alpha fold model of of DIDO1 (the N-terminal region highlighted by the study is blue). While this is not a realistic model, it nevertheless, highlights the fact that this protein is mostly disorganized albeit a few limited structural elements. The compounds from the screening libraries are adapted to engage active sites (deep pockets) of enzymes and to a lesser extend protein binding sites. These compounds engage their targets through short distance interactions distributed in a 3d space. This is not possible with disorganised protein such as DIDO which is mostly a linear structure. There is no easy way forward. If one does not want to intervene at the RNA level (complete gene extinction most probably leading to toxicity issues), the possibilities are very limited at the protein level. One may mimic the short linear motive of DIDO interacting with a key partner and drug the interaction by targeting the globular partner, not DIDO with a peptidomietic. A company such as PrismBiolabs in Japan (PRISM BioLab Co., Ltd.,) is specialised (and successful) in this approach. However, to allow this or a similar approach, the targeted interaction must be identified, confirmed to be biologically significant and then precisely described (partner and precise sequence from DIDO both identified). In addition, post translational modifications are often essential adding an extra layer of experimental complexity. In summary, like DIDO or transcription factors, most new targets candidates are not directly druggable with current chemical matter and require significant efforts prior to screening in order to try to engage them. #obesitytreatment #drugdiscovery #pharmaceuticalindustry #proteinproteininteractions #structuralbiology #medicinalchemistry

🧬 Understanding Pharmacogenomics (PGx) Did you know that our genetics can significantly influence how we respond to medications? Pharmacogenomics helps us understand the effectiveness of drugs and potential side effects based on our DNA. 🔍 Proactive vs. Reactive PGx Testing: - Proactive PGx Testing: Done before a diagnosis and prescription to optimize treatment from the start. - Reactive PGx Testing: Conducted after a diagnosis or when a medication isn't working as it should. Your body's metabolism (break down) of medications is shaped by your genetic makeup! 💊 The liver’s CYP450 enzymes are crucial in breaking down drugs, and there are four metabolizer types: - Poor metabolizer – You break down some medications very slowly compared to normal. This causes the levels of the medication in your body to increase, and you may experience side effects at standard doses. - Intermediate metabolizer – Some medications are broken down slower than average, but not as slow as a poor metabolizer. You could end up with increased medication levels in your body, potentially causing side effects. - Extensive (normal) metabolizer – You break down some medications at the normal rate. At the standard doses, you should have about the right amount of medicine in your body. - Ultrarapid metabolizer – Some medications are broken down more quickly than normal. You may not have enough medication in your body to experience symptom relief. By understanding these factors, we can tailor medication choices to individual needs, leading to better health outcomes! 🩺✨ Let's explore how our genetics can shape our healthcare journey! #Pharmacogenomics #PersonalizedMedicine #Genetics #MedicationManagement #MedicationSafety

🧬 Understanding Pharmacogenomics (PGx) Did you know that our genetics can significantly influence how we respond to medications? Pharmacogenomics helps us understand the effectiveness of drugs and potential side effects based on our DNA. 🔍 Proactive vs. Reactive PGx Testing: - Proactive PGx Testing: Done before a diagnosis and prescription to optimize treatment from the start. - Reactive PGx Testing: Conducted after a diagnosis or when a medication isn't working as it should. Your body's metabolism (break down) of medications is shaped by your genetic makeup! 💊 The liver’s CYP450 enzymes are crucial in breaking down drugs, and there are four metabolizer types: - Poor metabolizer – You break down some medications very slowly compared to normal. This causes the levels of the medication in your body to increase, and you may experience side effects at standard doses. - Intermediate metabolizer – Some medications are broken down slower than average, but not as slow as a poor metabolizer. You could end up with increased medication levels in your body, potentially causing side effects. - Extensive (normal) metabolizer – You break down some medications at the normal rate. At the standard doses, you should have about the right amount of medicine in your body. - Ultrarapid metabolizer – Some medications are broken down more quickly than normal. You may not have enough medication in your body to experience symptom relief. By understanding these factors, we can tailor medication choices to individual needs, leading to better health outcomes! 🩺✨ Let's explore how our genetics can shape our healthcare journey! #Pharmacogenomics #PersonalizedMedicine #Genetics #MedicationManagement #MedicationSafety