ABclonal Technology’s Post

DNA (Deoxyribonucleic acid) stores genetic information in its double helix structure (A, G, C, T). RNA (Ribonucleic acid) translates DNA's instructions into proteins using its single-stranded structure (A, G, C, U). Together, DNA and RNA facilitate cellular functions and heredity.#dna #rna #nucleotide #nucleoside

Ermin can be a name for a nice handsome man. Interestingly, it can be even a protein. Let us dive into the story of the protein named Ermin and this story can even be more interesting than porn or Kiwi and Ausie underbelly TV show.  I came across it while I was reading the paper on cytoskeleton regulation of Wang et al. 2020, Ermin is a p116RIP -interacting protein promoting oligodendroglial differentiation and myelin maintenance. Here is the link, https://lnkd.in/eb2qJdRd You can see Ermin is a cytoskeleton-related oligodendrocyte-specific protein associated with cytoskeleton regulation. It is also called also Juxtanodin. O my God, without Juxta you end up with Odin.   If you want to see more on its gene and expression and  protein structure, here is the ID in the EMBL protein data base and link to it.  The entry is IPR045346 and the hyperlink to https://lnkd.in/en7wD7sB

How to find the order of genes on chromosome We can see if two genes are linked, and how tightly, by using data from genetic crosses to calculate the recombination frequency. By finding recombination frequencies for many gene pairs, we can make linkage maps that show the order and relative distances of the genes on the chromosome. Youtube video: https://lnkd.in/dPRHYNB8 \#nikolays_genetics_lessons

How to determine sequence of genes on chromosome Gene mapping describes the methods used to identify the locus of a gene and the distances between genes. The essence of all genome mapping is to place a collection of molecular markers onto their respective positions on the genome. Molecular markers come in all forms. Youtube video: https://lnkd.in/dv3VhjZv \#nikolays_genetics_lessons

Webinar Alert! Do not miss the upcoming webinar from Devyser about the shifting distribution of hemoglobinopathy, and the need for expanded thalassemia genetic testing. In this webinar, Dr Robert Akkers from Universum Laboratorium will highlight the importance of implementing more streamlined testing and showcase how Devyser’s dedicated software, Amplicon Suite, aids data analysis. Register here: https://bit.ly/4eq6OBr 𝐃𝐚𝐭𝐞: 𝐉𝐮𝐧𝐞 𝟐𝟕, 𝟐𝟎𝟐𝟒 𝐓𝐢𝐦𝐞: 𝟏𝟐:𝟑𝟎𝐩𝐦 𝐈𝐒𝐓 #Thalassemia #Genetic #hemoglobinopathy

📣 New OCNDS research! Blanc et. al. published a case report about an individual with the R47Q variant in the CSNK2A1 gene including new symptoms such as clubfeet, eye misalignment, and small teeth. Read the full research explained here: https://loom.ly/xyFaaFs #ocnds #csnk2a1 #hopeintoaction #timeisnow

Antisense Oligonucleotides (ASOs) are short, synthetic nucleic acid sequences designed to bind specifically to complementary RNA sequences. They can influence gene expression by altering RNA processing, stability, or translation. ASOs are often used to induce exon skipping by binding to pre-mRNA and altering splicing patterns, leading to the exclusion of specific exons. This technique has important therapeutic applications, particularly for genetic disorders where splicing defects or mutations disrupt normal protein function. Check the link below to learn more about ASOs:

What are Additive genetic effects? Additive genetic effects occur when two or more genes source a single contribution to the final phenotype, or when alleles of a single gene \(in heterozygotes\) combine so that their combined effects equal the sum of their individual effects. Non-additive genetic effects involve dominance \(of alleles at a single locus\) or epistasis \(of alleles at different loci\). Youtube video: https://lnkd.in/dZ-ch3Zq \#nikolays_genetics_lessons

How to Locate Genes on Chromosomes Cell fusion has been used as a traditional technology for various purposes including gene mapping and production of antibodies. Youtube video: https://lnkd.in/dyTr6Cit \#nikolays_genetics_lessons

Can the presence of specific genetic alterations and MRD status help predict outcomes for adult patients with KMT2A-rearranged B-cell precursor ALL? A recent GRAALL study by Kim et al. explores this question. Check out our publication summary here to find out more: https://loom.ly/66-THPU #ALLsm #leusm