Actio Biosciences, Inc.’s Post

Don’t Miss This! Dive into the future of biomedicine with us next week in #SanDiego! Join us next week at the Festival of Biologics San Diego for an interesting panel discussion brought to you by Business Location Switzerland and Swissnex in San Francisco. What’s on the Agenda?  We’re diving deep into RNA technology and its role in developing breakthrough antibody therapies to fight critical illnesses such as cancer, Alzheimer's, and autoimmune diseases. Get ready to explore the latest trends, groundbreaking research, and the challenges ahead with top experts from both #Switzerland and the #US. Meet Our Esteemed Panelists: - Rudi Micheletti, spearheading Biology and Functional Genomics at Haya Therapeutics. - Susan Szathmary, MD, PhD, leading the charge at the Open Biopharma Research and Training Institute. - Dimitrios G. Zisoulis, the mind behind RNA Therapeutics at Johnson & Johnson. - Gene Yeo, a pioneering Professor at UCSD’s Dept of Cellular and Molecular Medicine and a key figure at the UCSD Institute for Genomic Medicine. The panel discussion "Decoding the Dark Genome through RNA Technology: Ways Forward with Swiss and US Innovation’” will be moderated by the insightful Julio de Unamuno IV, Executive Director of HomeLab at UCSD. Don’t miss out on this opportunity to gain insights from leading minds in the field and discover how Swiss and US expertise is paving the way forward in biotech innovation. #biotechnology #RNAtechnology #innovation #whyswitzerland #FestivalofBiologics #healthcare #pharma

It’s been 15 incredible years since 3D cell culture began revolutionizing how we study cells and tissues! Here’s a snapshot of how 3D cell cultures and organoids have made a profound impact on the scientific community and beyond: ➡️ Growth Explosion: The global 3D cell culture market is projected to reach $2.5 billion by 2028, growing at a CAGR of 18%. ➡️ Cancer Research: Due to their ability to mimic the body's natural environment, 3D in vitro studies have revealed insights into tumorigenesis that have not been detectable with traditional 2D models. ➡️ Drug Discovery: Compared to 2D cultures, 3D cell cultures more accurately predict the efficacy or toxicity of drug treatment, paving the way for new drug discoveries. ➡️ Ethical Advances: By reducing the need for animal testing, 3D cell cultures contribute to more ethical research practices while offering a more relevant model of human biology. Cheers to the first 15 years of groundbreaking advancements - and, all those to come! #CellResearch #Organoids

🚀 Exciting News Alert! 🚀 We’re thrilled to share some exhilarating news with all of you today! 🎉 Our latest scientific venture has just been published in International Journal of Molecular Sciences MDPI from MDPI group! 📚🔬 🔥 This MYLeukaemia Project achievement marks the second publication this week 🔥 making it an amazing week indeed for our team! We are immensely proud of the dedication and hard work of everyone involved. 🔍 Titled "Transforming the Niche: The Emerging Role of Extracellular Vesicles in Acute Myeloid Leukaemia Progression" this review paper represents a significant milestone in our quest to understand Acute Myeloid Leukaemia (AML) at its core -establishing the 🗺️ Updated Blueprints of known EV-signalling networks hijacked by Leukemic Stem Cells (LSCs). 💡 Our comprehensive review led by Hugo R. Caires highlights the profound impact of EVs in promoting Leukaemia hallmarks and drug resistance through complex crosstalk mechanisms. 📊 Here we went to a considerable effort to map the evolving terrain of EV-mediated interactions within the bone-marrow hematopoietic niches with a temporal perspective, underscoring their transformative potential for the next-generation of tailored niche-targeted therapeutic intervention. 💊🎯 🔬 Our review also underscores the promise held by cutting-edge methodologies like organ-on-a-chip (OoC) systems and single-EV analysis technologies in unravelling the intricate network of AML–niche interactions, paving the way for disruptive niche-targeted therapies that could revolutionize leukaemia eradication efforts. 🎯 📄 Dive into the full paper here: https://lnkd.in/dtZkVkH9 This publication represents a collaborative effort fuelled by dedication, passion, and a relentless pursuit of scientific excellence. 🌐 Congratulations to everyone involved for this remarkable achievement!! 🙌 Manuel Mendes, Ana Carolina Monteiro, Estrela Neto, Cristina Barrias, Manuel A. Sobrinho-Simões, Delfim Duarte & Hugo R. Caires* Let's continue pushing the boundaries of scientific discovery together to beat Leukaemia! 💪 #Science #Research #AML #ExtracellularVesicles #BoneMarrowNiche #TherapeuticIntervention #IJMS #ScientificBreakthrough #i3S #MYLeukaemia

In case you missed the big news last week, we've entered into a license and distribution agreement with Thermo Fisher Scientific for spatial biology systems and reagents. The agreement between Akoya and Thermo Fisher allows Akoya to market a combination of its spatial biology products, such as PhenoCycler-Fusion and PhenoImager, with Thermo Fisher's ViewRNA in situ hybridization assays. This collaboration will provide researchers with a streamlined workflow for rapid and whole-slide imaging of RNA and protein biomarkers, enabling them to gain comprehensive insights from tissue samples. https://bit.ly/3TSMr8g GenomeWeb #ThermoFisher #SpatialBiology #SpatialMultiomics #SpatialOmics #RNA #WholeSlide

CSCCG, AMI BioScience, offers cancer cell culture training & laboratory out sourcing facility. Laboratory Facilities established: Molecular Biology facilities, Cell culture facilities, FACS facilities and Genomics Data analysis platform https://lnkd.in/gXV3mQw https://lnkd.in/ghxd39i3 https://lnkd.in/fP9wZrH https://lnkd.in/ghrefqPZ #amibioscience,#molecular biology, #geneexpression, #cancerlab, #pharmaceuticalproject, #medicalresearch, #molecularbiology, #gene, #genecloning, #rtpcr, #qpcr, #geneexpression, #mrna, #moleculabiologylab, #westernblot, #rnabloting, #snpanalysis, #multiplexpcr, #sangersequencing, #westernblotting, #mrnacloning, #mirnaexperssion. #amibioscience, #Biotechnology, #training#cancercells, #Cellculture,#MolBio

Read and share recently published articles in Biopreservation and Biobanking with free access through January 12th: Detection and Correction of Sample Misidentifications in a Biobank Using the MassARRAY System and Genomic Information Hisaaki Kudo, Noriko Ishida, Takahiro Nobukuni, Yuichi Aoki, Sakae Saito, Ichiko Nishijima, Takahiro Terakawa, Masayuki Yamamoto, Naoko Minegishi, Riu Yamashita, and Kazuki Kumada With the number of samples increasing in many biobanks, one of the most pressing tasks is recording the correct relationships between information and the specimens. Genomic information is useful in determining the identity of these specimens. The Tohoku Medical Megabank Organization is running one of the largest biobanks in Japan. Here, we introduce a management system, which includes the development of a new probe set for the MassARRAY system for use during the production of proliferating T cells (T cells) and lymphoblastoid cell lines (LCLs). We selected single nucleotide variants that could be detected by next-generation sequencing and showed high resolution with ~0.5 minor allele frequencies. After checking the set of probes against 96 samples from 48 people, we obtained no contradictory results in comparison with our genome sequence information. When we applied the set to our 3035 LCLs and 2256 T cells, the result showed 98.93% consistency with the corresponding genomic information. We surveyed the handling records of the 1.07% of samples that showed inconsistencies, and found that most had resulted from human errors (ID swapping between samples) during manual operations. After improving a few error-prone protocols, the error rate dropped to 0.47% for LCLs and 0% for T cells. Overall, the system that we developed shows high accuracy with easy and fast operability, and provides a good opportunity to improve the validation procedure to facilitate high-quality banking, especially in cases involving genomic information. https://lnkd.in/e2MKdvzb #Biobanking #Biospecimen #Biorepository #Biobank #Biopreservation #SampleManagement #ISBER #BiopreservationAndBiobanking

We hope to see you at the 2nd Annual MarketsandMarkets ImmunoBio Series. Discover how our AI-powered spatial biology tools for exploring the tumor microenvironment deliver quantitative, high confidence insights in just a fraction of the time of conventional methods. On October 15 at 10:00 am CEST, Angela Vasaturo, Director of Scientific Affairs at Ultivue, will present: “Ultrasensitive ISP assays for high quality spatial insights.” ➡️See how Ultivue’s ultrasensitive InSituPlex® assays capture an unprecedented view into the vast complexity of cellular interactions within the tumor microenvironment and enable researchers to localize biomarkers directly within tissue. ➡️Learn how InSituPlex technology enhances understanding of spatial tissue biology at scale, reducing biomarker-based analytic cycle times by more than 70% and accelerating the drug development process. ➡️Angela will also share new data demonstrating how the technology’s proprietary signal amplification enables biomarker detection with significantly higher sensitivity, compared to alternate approaches. We hope to see you there! #Spatialbiology #cancerresearch

Are you interested in the past, present, and potential future applications of discovery biology to better understand mechanisms of and therapeutic targets for #osteoarthritis? Grateful to be included in this thoughtful review describing what we have learned and how to leverage advances in #proteomics, #transcriptomics & #metabolomics in OA, led by Mohit Kapoor out now in Osteoarthritis and Cartilage Journal. We speculate on what the future can hold - including the exciting potential value of spatial and multi-omics approaches! Shoutout to the awesome team behind this important contribution: Farooq Rai, Annemarie Lang, Tristan Maerz, Ph.D., Jeroen Geurts, Cristina Ruiz Romero, Ron June, Yolande F. M. Ramos, Sarah Rice, S. Amanda Ali, PhD, Chiara Pastrello, Igor Jurisica, Tom Appleton, MD PhD, Jason Rockel, PhD https://lnkd.in/g9YbqBQm PDF available by request.

Syncell is attending the Single-Cell Genomics Gordon Research Conference in Switzerland, ongoing until May 24th. This event explores how diverse cell types collaborate to enable tissue functions, with a focus on the intricate gene networks within cells. Technological advancements now allow for the detailed characterization of individual cells at the genomic scale within intact tissues. Single-cell and spatial omics methods, including proteomics, have emerged to measure various cellular properties with high spatial resolution. The conference unites life sciences and medical leaders with innovators in single-cell and spatial technologies to discuss recent advancements and their implications for diagnostics, therapeutics, and precision medicine. #GRC #SingleCellGenomics