Drug-drug Interactions (DDI) are an inevitable by-product of polypharmacy. DDIs can be divided into pharmacokinetic and pharmacodynamic interactions. Current regulatory guidance is focused on pharmacokinetic interactions. It is important to understand the underlying mechanics and differences between enzyme inhibition subtypes to be able to set up proper incubation methods and to interpret the results correctly. Our e-book on Drug-drug Interactions will introduce you inhibition kinetics along with a comparison between the enzyme sources most often used in CYP inhibition studies. Enzyme induction is addressed in the book from CYP point-of-view as CYP induction is the most studied form of induction in drug metabolism and is required by regulatory authorities. The book also covers in vitro to in vivo extrapolation of CYP inhibition and induction, and familiarizes readers to different types of models used for DDI prediction. You can download your free copy of this helpful resource here: https://lnkd.in/dbnihjEz Admescope a Symeres company #Admescope #Symeres #DDI #drugdruginteractions #polypharmacy #CYP450 #drugdiscovery
