Check out this review from Biophysics Reviews! Authored by: Moosung Lee, Hervé Hugonnet, Mahn Jae Lee, Youngmoon Cho, & YongKeun Park #opticaltrapping #physics #biophysics Kit Parker Learn more 👇
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⭐ Get ready to embrace the undiscovered, #CuriousMinds! 🔬 Super-resolution microscopy is an unparalleled choice for scientific research and exploration. With its exceptional ability to beat the diffraction limit of light, this technique allows researchers to visualize structures and processes smaller than 200 nm, and down to single molecules. It allows researchers to study biological structures and processes at the nanoscale, providing invaluable insights into cellular organization, molecular interactions, and disease mechanisms. 👨🔬 By improving image resolution by 10 times compared to traditional optical microscopy, super-resolution techniques such as dSTORM and PALM enable scientists to study subcellular structures with unprecedented precision, both in fixed and live specimens. The ability to perform single-molecule live cell imaging and tracking opens doors to investigating dynamic processes in real time, further enhancing our understanding of cellular dynamics and intracellular signaling. Learn more ➡️ https://hubs.li/Q02tp1Vs0 #SuperResolution #Microscopy #ScientificResearch #Exploration #DiffractionLimit #Visualization #Nanostructures #SingleMolecules #BiologicalStructures #CellularOrganization #MolecularInteractions #DiseaseMechanisms #OpticalMicroscopy #dSTORM #PALM #SubcellularStructures #LiveSpecimens #SingleMoleculeImaging #LiveCellImaging #CellularDynamics
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Quantum-enhanced diamond molecular tension microscopy for quantifying cellular forces SCIENCE ADVANCES https://lnkd.in/gfrbHKW6
Quantum-enhanced diamond molecular tension microscopy for quantifying cellular forces
science.org
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Hungary: Impact of e-cigarette liquid on porcine lung tissue – ex vivo confocal Raman micro-spectroscopy study
Impact of e‐cigarette liquid on porcine lung tissue – ex vivo confocal Raman micro‐spectroscopy study
onlinelibrary.wiley.com
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Liaison in Biomedical Nanotechnology | Scientific Writer | UTQ-certification in Teaching and Supervising
🧬 Can the chirality of single molecules be detected with a high sensitivity? 🧲 Can one measure the effects of magnetic hyperthermia on a single-particle level? ⚡ Can one probe the ultrafast magnetization dynamics of small structures with a spatial resolution down to tens of nanometers? 📚 To find the answers to the questions above (and many others!), check our mini-review "Single-Particle Photothermal Circular Dichroism and Photothermal Magnetic Circular Dichroism Microscopy" recently published in Nano Letters as a joint effort of groups from Universiteit Leiden and Eindhoven University of Technology: https://lnkd.in/ecrpkrMm 👥 Authors: Subhasis Adhikari, Mariia Efremova, Patrick Spaeth, Bert Koopmans, Reinoud Lavrijsen, and Michel Orrit. #magnetic_mariia
Single-Particle Photothermal Circular Dichroism and Photothermal Magnetic Circular Dichroism Microscopy
pubs.acs.org
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ONLINE WORKSHOP - Registration now open 🔬 Next Generation Expansion Microscopy using Magnify with Yongxin (Leon) Zhao, Associate Professor at Carnegie Mellon University 📆 June 6th (The webinar will be held twice to accommodate our global audience) Register your place here: ⏰ 2pm BST/3pm CEST: https://lnkd.in/eGv25riM ⏰ 2pm CT: https://lnkd.in/eRn3yUYi Discover the future of nanoscale biological imaging. This workshop will cover: 🔹Introduction to Magnify for expansion microscopy 🔹Protocols and how it can be used with various biological specimens 🔹How microMagnify can be used for studying pathogen ultrastructures and pathogen-host interactions #ProteintechEvents #Microscopy
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This laser manipulation tool could enable biofilms to be used for sensors and more: https://ow.ly/YNvF50Qvxwn As a precise tool for influencing biofilm growth patterns, optical traps using lasers at different wavelengths can be used to stimulate and suppress biofilm growth. The California State University, Northridge researchers' optical method is the first step in the long-term project to create microscopic building materials from readily available resources like bacteria. #Lasers #Biology #Photonics
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### The Pioneering Field of Cryoelectron Tomography Cryoelectron tomography (cryo-ET) is a cutting-edge technique in structural biology that allows scientists to visualize cells and their components in near-native states at molecular resolution. This method involves rapidly freezing biological samples to preserve their structures and then imaging them with an electron microscope. Recent advancements in cryo-ET have provided detailed insights into cellular machinery, such as ribosomes, viruses, and protein complexes, revealing their intricate arrangements and functions. Cryo-ET is revolutionizing our understanding of cellular architecture and processes, offering potential breakthroughs in drug development and disease research. #CryoelectronTomography #StructuralBiology #MolecularImaging
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🗞️Exciting news for the #cryoET community! A recent study, "Thinner is not always better: Optimising cryo lamellae for subtomogram averaging," challenges the conventional wisdom in cryo-ET. Key findings of the study: 💡Lamellae up to 180 nm thick do not negatively impact STA resolution, suggesting we can capture more cellular context without sacrificing quality. 💡Gallium-ion-induced damage from cryo-FIB milling extends up to 30 nm from the lamella surface, informing our understanding of milling effects on samples. 💡Ribosomes were used as probes to assess the impact of lamella thickness and ion-induced damage on STA resolution. Implications: 📝This work provides practical guidance for optimizing cryo-ET and STA workflows, potentially streamlining the process of in situ tomography of macromolecular complexes in cells. 📝The findings indicate that cryo-FIB milling is a robust technique for high-resolution structural studies, even with slightly thicker lamellae. The study was conducted by researchers from various departments within the Max Planck Institute of Biophysics and other institutions, and it was supported by the Max Planck Society and the Chan Zuckerberg Initiative DAF. Link to the full research article in the comments section. #CryoElectronTomography #SubtomogramAveraging #StructuralBiology #ResearchUpdate #CryoEM
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Happy #LamininDay! To celebrate the 5-21, we wanted to ask you: ever pondered how clearly we can observe proteins under a microscope? From 100,000 nm to 1 nm – from the limits of the human eye to atomic force microscopy. Let us introduce you to the dynamical full-length laminin protein! Even though laminins are large among their peers, they remain invisible even under conventional microscopy. However, thanks to advancements in imaging, a team of scientists has now captured dynamic conformational changes along full-length laminin isoforms. This study not only sheds light on the intricate dynamism of laminin proteins but also makes us wonder: could the entire extracellular matrix be teeming with lively movement as well? Read more about it ➡ https://lnkd.in/dWs-Z7gG #CellCulture #Science #Microscopy #HSAFM #Biolaminin
A video showing dynamic movements of full-length laminin protein, observed using high-speed atomic force microscopy by Akter et al. 2024 (video S4, CC
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Our paper about:" Modelling small block aperture in an in-house developed GPU-accelerated Monte Carlo-based dose engine for pencil beam scanning proton therapy" is published in Physics in Medicine and Biology. In this work, we developed a novel method to enhance an in-house GPU accelerated virtual particle (VP)-based Monte Carlo (MC) proton dose engine (VPMC) to model aperture blocks in both dose calculation and optimization for pencil beam scanning proton therapy (PBSPT)-based stereotactic radiosurgery (SRS). High agreement with high efficiency was achieved. For more details, please refer to the following link: https://lnkd.in/gZjaJjMx #cancerresearch #protontherapy #radiationtherapy
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