Ajinomoto Bio-Pharma Services’ Post

【Piperidine/Azetidine Scaffolds】 Piperidine and azetidine are usually used as a scaffold of bioactive compounds. They were used as an important scaffold of ACT-1016-0707, potent and selective lysophosphatidic acid receptor subtype 1 receptor (LPAR1) antagonist [1, 2]. In this publication, azetidine was used as a less lipophilic scaffold than piperidine in order to improve ADME properties. We offer piperidine/azetidine scaffolds for drug discovery. [1] https://lnkd.in/gWJ-kK3D [2] https://lnkd.in/gkP4bMMw More details of K-BB : https://lnkd.in/gpEg295V Contact us : shiyaku@kishida.co.jp #drugdiscovery #chemistry #buildingblock #piperidine #azetidine #LPA

The diverse nature and the chemical modification of #oligonucleotide therapeutics leads to the requirement for multiple separation techniques to characterize the quality attributes. This new data discussed two common chromatographic approaches IP-RP and SAX being used as orthogonal methods to analyze short oligonucleotides ranging from 15-40 mer. The mixture of sample with 5 base difference each was successfully separated on the Proeteomix SAX NP5 4.6 x 250 mm column via ion exchange mode based on the length of oligos (left figure), while the same sample was also well separated by the Bio-C18 300 Å column via Ion pare mode with TEAA as ion pair regent (right Figure). On both phases, the sample were eluted according to the length of the oligos, reflecting the stronger interaction of longer oligo with both IEX and RP resin surface of the columns. Read more here: https://lnkd.in/eeS2Yz6h

Regioselective Homolytic C2–H Borylation of Unprotected Adenosine and Adenine Derivatives via Minisci Reaction Effective for the late-stage borylation of some important biomolecules as well as a few antiviral and antitumor drug molecules, such as AMP, cAMP, Vidarabine, Cordycepin, Tenofovir, Adefovir, GS-441524. Preliminary antitumor evaluation, derivation of the C2-borylated adenosine to other analogues with high-value functionalities, along with the CuAAC click reactions, suggest the potential application of this methodology in drug molecular optimization studies and chemical biology. https://lnkd.in/gSB8Vr38

Innovation That Drives Breakthroughs | Agilent https://lnkd.in/gG5GfZEc More in-depth data about sequence, structure, modifications, and purity can help you make better decisions about your candidate molecules. The new Agilent ExD cell with the Agilent ExDViewer analysis software easily and cost-effectively adds electron capture dissociation (ECD) to the capabilities of the 6545XT AdvanceBio LC/Q-TOF. So, you can elevate your peptide and protein analyses and minimize costly delays in your research. #biosimilars #biopharma #PTM #glycopeptides #topdownMS #peptides

Check out my publication in AMP encapsulation in International Journal of Molecular Sciences "Antimicrobial Peptide Octominin-Encapsulated Chitosan Nanoparticles Enhanced Antifungal and Antibacterial Activities" https://lnkd.in/gHqtw7rT #encapsulation #AMP #chitosan

Over the last number of years, analytical technologies for assessing the purity of a synthetic peptide have changed significantly, with U(H)PLC methods utilising media with specific properties designed to separate peptide impurities used in almost all peptide analyses. In the most recent edition of Chemistry Today, Steve McIntyre discusses the holistic approach taken at Almac to ensure peptides and other large molecules produced for clinical and commercial purposes are still able to meet the stringent regulations and increased scrutiny. Read more: https://hubs.li/Q02z2C9V0 #drugdevelopment #peptide

The TETRAS by Thuramed is at the forefront of peptide synthesis technology. Capable of performing up to 108 syntheses at once with customizable sequences and lengths, the TETRAS Peptide Synthesizer combines efficiency, flexibility, and high purity with automated technology. Now enhanced with heating options for even faster synthesis and improved purity. Learn more at the-tetras.com #peptidesynthesis #SPPS #peptidesynthesizer #proteomics #bestpeptidesynthesizer

We’re excited to attend the 37th European Peptide Symposium in Florence! Join us to explore the latest trends in peptide synthesis and discover our groundbreaking UE-SPPS No Wash methodology. Let's discuss how this new technology is revolutionizing solid-phase peptide synthesis. Hope to see you there! #Peptides #PeptideSynthesis #EuropeanPeptideSymposium

Peptide synthesis: Alloferon-1 CAS: 347884-61-1   Product name: Alloferon-1 CAS: 347884-61-1 Sequence: His-Gly-Val-Ser-Gly-His-Gly-Gln-His-Gly-Val-His-Gly|H-His-Gly-Val-Ser-Gly-His-Gly-Gln-His-Gly-Val-His-Gly-OH Molecular formula: C52H76N22O16 Molecular weight: 1265.32 Source: Synthesis Appearance: white powder Purity: >95.0% Shelf life:> 2 years Notice: For research use only   #peptide #Alloferon #Alloferon1 #cosmeticpeptide #custompeptide #peptidesynthesis 

【Pyridone Analogs】 Pyridones are one of the useful heterocycles in drug discovery. They have some unique characteristics; 1) acting as a bioisostere for amides, pyridines and other heterocycles 2) serving both as a hydrogen bond acceptor and/or a donor 3) affecting the molecule’s lipophilicity, aqueous solubility and metabolic stability We offer various pyridone analogs for drug discovery. <Example of using pyridones> Discovery of BIO-8169─A Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation https://lnkd.in/gwBQW6Qe Contact us : shiyaku@kishida.co.jp #drugdiscovery #chemistry #buildingblock #pyridone