Damilare Akingbade’s Post

A chemical proteomics approach to map protein-ligand interactions across the human proteome as a resource for drug development: Even though scientists have made significant progress in determining and predicting protein structures, finding small-molecule ligands for most proteins remains difficult. The authors addressed this challenge by creating a library of around 400 ligand fragments linked to a light-activated cross-linker. Using this library, they identified about 50,000 statistically significant interactions with over 2,500 proteins. Notably, a large portion of these proteins had no previously known ligands. Biochemical experiments validated these findings. This rich dataset of interactions also served as the foundation for developing a machine-learning model that can predict fragment properties and how they interact with proteins. The authors have made their work available to the scientific community through an online platform that will facilitate drug development. The original article was published in Science: https://lnkd.in/ernitw9Z. Thanks for sharing it with me brain(Brian) B.. https://lnkd.in/ewYvj5Na #genetics #genomics #precisionmedicine #genomicmedicine #bioinformatics #ai #drugdiscovery #drugdevelopment #pharma #clinicaltrials #proteins #smallmolecule #biochemistry #chemistry #biophysics #bioengineering #biotechnology #innovation #research #science #sciencecommunication

Genetic Engineering & Biotechnology News covers Atomwise’s recent paper in Nature Scientific Reports. In the paper published in Scientific Reports titled, “AI is a viable alternative to high throughput screening: a 318-target study,” AtomNet was applied to 318 targets identified from collaborations from over 250 academic labs across 30 countries. The platform successfully identified structurally novel hits for 235 of 318 targets evaluated, and provided a success rate of 74%, an improvement upon literature estimated HTS success rates of 50%. “It’s important to be able to go into novel parts of chemical space because if you want to help patients, you have to be meaningfully differentiated in the clinic,” said Abraham Heifets, CEO of Atomwise, highlighting that such differentiation comes from providing first-in-class strategies when no treatment exists or improving upon existing strategies. Read the article: 👇👇 https://lnkd.in/e9UEzscc #AI #drugdiscovery

I am happy to share that a long awaited article published in progress in Molecular Biology and Translational Science (Impact Factor = 3.6) "System biology approaches for drug repurposing" #Drug repurposing #Medication repurposing #Drug development #Network biology #System biology #Innovation #Healthcare

Another interesting perspective on how single cell approaches can work not only for target identification, but also towards augmenting clinical diagnostic decision making beyond whole genomic approaches. Beyond the standard role scRNA plays in the discovery process pioneered by organizations like Cellarity, uniting single cell data with traditional med chem models from Exscientia could also prove a valuable approach for ligand based drug discovery. #singlecell #drugdiscovery #precisionmedicine https://lnkd.in/grnH3pE3

CELL BIOLOGY AND RECOMBINANT DNA TECHNOLOGY Following on from BIOTECHNOLOGY AND BIOPHARMACEUTICALS, this Module goes a level deeper in its explanation of cell biology and how cells can be manipulated to produce therapeutic proteins. An overview is provided of the functioning of mammalian cells, followed by an explanation of the roles played by DNA and RNA in producing proteins in cells. The steps involved in recombinant DNA technology are outlined, including DNA amplification, insertion of target genes into suitable vectors, before cell culturing is explained. Follow SKILLPAD - digital learning for life sciences on LinkedIn at https://lnkd.in/ejd-z5Am for more news and updates. CELL BIOLOGY AND RECOMBINANT DNA TECHNOLOGY learning objectives, description and screenshots here: https://lnkd.in/e4_Ybu35 Schedule a DEMO by contacting info@skillpad.com #cellbiology #recombinantdna #bioprocessing #bioreactors #biologics #biopharmaceuticals #biotechnology #biomanufacturing #lifesciences

Check out this paper written by my brother based on one of his research at the Johns Hopkins University School of Medicine. Very complicated but very insightful.

🧬💡The Polymerase Chain Reaction (PCR) Market is rapidly evolving! With its pivotal role in diagnostic testing and research, the demand for PCR technologies is soaring. As innovations drive efficiency and accuracy, PCR remains a cornerstone of modern molecular biology and clinical diagnostics. #PCR #Biotechnology #MolecularBiology #Diagnostics #Research #Innovation #HealthcareTechnologies #PolymeraseChainReaction

📃 New Publication from REMEDi4ALL!📃 Our partners at the Institute for Molecular Medicine Finland (FIMM) have recently published their latest research in the journal Bioinformatics. The paper introduces a new computational method aimed at predicting the activities of drugs across >1400 human proteins. Through comprehensive analysis of different protein families, researchers identified effective ways to predict new drug-target interactions, which could extend the use of already approved drugs. This work could play a significant role in advancing drug repurposing and improving therapeutic approaches. Read the full article here ➡️ [https://lnkd.in/eFd-TqYm].] #REMEDi4ALL #Bioinformatics #DrugDiscovery #Research

CELL BIOLOGY AND RECOMBINANT DNA TECHNOLOGY Following on from BIOTECHNOLOGY AND BIOPHARMACEUTICALS, this Module goes a level deeper in its explanation of cell biology and how cells can be manipulated to produce therapeutic proteins. An overview is provided of the functioning of mammalian cells, followed by an explanation of the roles played by DNA and RNA in producing proteins in cells. The steps involved in recombinant DNA technology are outlined, including DNA amplification, insertion of target genes into suitable vectors, before cell culturing is explained. Follow SKILLPAD - digital learning for life sciences on LinkedIn at https://lnkd.in/ejd-z5Am for more news and updates. CELL BIOLOGY AND RECOMBINANT DNA TECHNOLOGY learning objectives, description and screenshots here: https://lnkd.in/e4_Ybu35 Schedule a DEMO by contacting info@skillpad.com #cellculture #cellbiology #biopharmaceuticals #biotechnology #bioprocessing #biologics #biomanufacturing #biosystems

How to identify the right protein inhibitors depending on the situation?🎯 As useful as protein inhibitors can be in identifying the molecular mechanisms of various diseases, finding the right inhibitors to answer specific scientific questions poses a challenge for researchers.❓ To address this challenge, Santa Cruz Biotechnology (SCBT) is conducting a project to identify suitable protein inhibitors through literature research and wet lab experiments and compiling results in a free online resource. Find out more in the article below!⬇️ https://lnkd.in/dZdEH4xc #proteininhibitors #biomedicalresearch #drugdiscovery #molecularmechanisms #scientificinquiry #researchchallenges