Aliki Perdikari’s Post

Phospholipidomics is a specialized branch of #lipidomics that focuses on the characterization and quantification of phospholipids. By using sensitive analytical techniques, #phospholipidomics enables researchers to better understand the metabolism and activities of phospholipids in #brain disorders such as Alzheimer’s and Parkinson’s diseases. In the 🧠, identifying specific phospholipid #biomarkers can offer valuable insights into the underlying molecular features and biochemistry of these diseases through a variety of sensitive analytical techniques. Phospholipidomics has emerged as a promising tool in clinical studies, with immense potential to advance our knowledge of neurological diseases and enhance diagnosis and treatment options for patients. In the present paper, we discussed numerous applications of phospholipidomics tools in clinical studies, with a particular focus on the neurological field. By exploring phospholipids’ functions in #neurological diseases and the potential of phospholipidomics in clinical research, we provided valuable insights that could aid researchers and clinicians in harnessing the full prospective of this innovative practice and improve patient outcomes by providing more potent treatments for neurological diseases. To further explore this topic, kindly visit: https://lnkd.in/dQ_XQkP2

Editorial Share From Our EB Massimiliano Filosto 🔌 Bridging the Gap: Translational Medicine and Novel Therapies in Neuromuscular Diseases 📣 https://lnkd.in/gbwp6qdf 📌 Journal of Integrative Neuroscience #neuromuscular #neurons #peripheralnerves #muscles #OpenAccess #Editorial #articles The emergence of novel therapies for neuromuscular diseases represents a beacon of hope for millions of individuals worldwide. From gene-based treatments to precision-medicine approaches, the landscape of disease management is undergoing a profound transformation. As we continue to push the boundaries of medical science, it is imperative that we prioritize accessibility, equity, and innovation to ensure that these groundbreaking therapies reach all those in need.

TALK ALERT! We are at the 12th Alzheimer’s & Parkinson’s Drug Development Summit today. If you are there, make sure to attend the talk by Neil Matharoo, bit․bio at 11 am. If you’re not attending the summit, don’t worry. You can learn more about our AD/PD disease model cells here: https://hubs.ly/Q02tYb1d0 #research #DrugDiscovery #science #neuroscience #data #talk #CRISPR #optiox #ioCells #ioDiseaseModelCells #ioCRISPRReadyCells #ioMotorNeurons #Microglia #ioGlutamateticNeurons #HTS #Conference

☑️ *READ ASTRACT BELOW:* Keywords: Artificial intelligence; Cardiovascular diseases; Clinical genomics; Clinical trials; Microphysiological systems; Organoids; Personalized medicine; iPSC. Cardiovascular diseases persist as a global health challenge that requires methodological innovation for effective drug development. Conventional pipelines relying on animal models suffer from high failure rates due to significant interspecies variation between humans and animal models. In response, the recently enacted Food and Drug Administration Modernization Act 2.0 encourages alternative approaches including induced pluripotent stem cells (iPSCs). Human iPSCs provide a patient-specific, precise, and screenable platform for drug testing, paving the way for cardiovascular precision medicine. This review discusses milestones in iPSC differentiation and their applications from disease modelling to drug discovery in cardiovascular medicine. It then explores challenges and emerging opportunities for the implementation of 'clinical trials in-a-dish'. Concluding, this review proposes a framework for future clinical trial design with strategic incorporations of iPSC technology, microphysiological systems, clinical pan-omics, and artificial intelligence to improve success rates and advance cardiovascular healthcare. Wu X, Eur Heart J. 2024 Oct 21;45(40):4275-4290. doi: 10.1093/eurheartj/ehae519. PMID: 39270727; PMCID: PMC11491156 #Gesundheit #Bildung #Fuehrung #Coaching #Mindset #Motivation #Gehirn #Neuroscience #Psychologie #Persoenlichkeitsentwicklung #Kindheit #KeyNoteSpeaker #Humangenetik #Biochemie #Neuroleadership #Ernaehrung #Transformation #Stress #Demografie #Gender #Age #interkulturelleKompetenz #Epigenetik #Veraenderung #EmotionaleIntelligenz #Change #Gesellschaft #Organisationsentwicklung #Philosophie #Beratung # Quantum

Lysosomes at the heart of cardiac beating The lysosome is, probably, the less studied calcium store. A recent study found that lysosomes are in close proximity to other calcium-handling organelles in the heart muscle cells of various mammals, including humans. This close association is disrupted in atrial fibrillation, a condition that causes irregular heartbeat. The study suggests that lysosomes may play a role in regulating heart rhythm. The manuscript is available as Preprint: https://lnkd.in/e4Ww3NKc. #genetics #genomics #precisionmedicine #genomicmedicine #lysosome #heart #muscle #cardiovascular #health #physiology #peacemaker #calcium #metabolism #biomarkers #biotechnology #innovation #research #science #sciencecommunication

📃Scientific paper: Brain‐Penetrating and Disease Site‐Targeting Manganese Dioxide‐Polymer‐Lipid Hybrid Nanoparticles Remodel Microenvironment of Alzheimer's Disease by Regulating Multiple Pathological Pathways Abstract: Finding effective disease‐modifying treatment for Alzheimer's disease remains challenging due to an array of factors contributing to the loss of neural function. The current study demonstrates a new strategy, using multitargeted bioactive nanoparticles to modify the brain microenvironment to achieve therapeutic benefits in a well‐characterized mouse model of Alzheimer's disease. The application of brain‐penetrating manganese dioxide nanoparticles significantly reduces hypoxia, neuroinflammation, and oxidative stress; ultimately reducing levels of amyloid β plaques within the neocortex. Analyses of molecular biomarkers and magnetic resonance imaging‐based functional studies indicate that these effects improve microvessel integrity, cerebral blood flow, and cerebral lymphatic clearance of amyloid β. These changes collectively shift the brain microenvironment toward conditions more favorable to continued neural function as demonstrated by improved cognitive function following treatment. Such multimodal disease‐modifying treatment may bridge critical gaps in the therapeutic treatment of neurodegenerative disease. Continued on ES/IODE ➡️ https://etcse.fr/5tXHc ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you. #alzheimer #science #health

📃Scientific paper: Brain‐Penetrating and Disease Site‐Targeting Manganese Dioxide‐Polymer‐Lipid Hybrid Nanoparticles Remodel Microenvironment of Alzheimer's Disease by Regulating Multiple Pathological Pathways Abstract: Finding effective disease‐modifying treatment for Alzheimer's disease remains challenging due to an array of factors contributing to the loss of neural function. The current study demonstrates a new strategy, using multitargeted bioactive nanoparticles to modify the brain microenvironment to achieve therapeutic benefits in a well‐characterized mouse model of Alzheimer's disease. The application of brain‐penetrating manganese dioxide nanoparticles significantly reduces hypoxia, neuroinflammation, and oxidative stress; ultimately reducing levels of amyloid β plaques within the neocortex. Analyses of molecular biomarkers and magnetic resonance imaging‐based functional studies indicate that these effects improve microvessel integrity, cerebral blood flow, and cerebral lymphatic clearance of amyloid β. These changes collectively shift the brain microenvironment toward conditions more favorable to continued neural function as demonstrated by improved cognitive function following treatment. Such multimodal disease‐modifying treatment may bridge critical gaps in the therapeutic treatment of neurodegenerative disease. Continued on ES/IODE ➡️ https://etcse.fr/5tXHc ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you. #alzheimer #science #health

Dr. Yeran Bai and colleagues have recently published a groundbreaking paper titled "Single-cell mapping of lipid metabolites using an infrared probe in human-derived model systems" in Nature Communications, addressing the pressing need for advanced techniques in metabolic imaging, particularly at the single-cell level. The study introduces a novel approach by employing an azide-tagged infrared probe combined with Optical Photothermal Infrared Spectroscopy (O-PTIR) to enhance the understanding of lipid metabolism in cells. This innovative method offers improved specificity and efficiency in lipid detection compared to traditional methods. The study highlights the unique advantages of O-PTIR over other vibrational spectroscopy techniques, such as its immunity to fluorescence background and cost-effectiveness. The findings deepen our understanding of lipid-related metabolic diseases and pave the way for new therapeutic strategies. Bai et al.'s research marks a significant advancement in metabolic imaging, offering detailed, cell-type-specific insights into lipid metabolism and its role in health and disease. #OPTIR #azide #lipiddetection #naturecommunications

When it comes to lipid analysis, our team is one of the best around. What they have created in the NeuroLipid Panel (NLP) is pretty spectacular! Our NLP can provide rapid turnaround, fully quantitative analysis on well over 200 lipids across a range of sample types. All major classes and subclasses of lipids assessed. Get in touch with the team to discuss how the NLP can enhance your research and development #lipids #biomarkers #neurodegenerativedisease #alzheimers #parkinsons #GSL