AJMC - The American Journal of Managed Care’s Post

#DYK: We recently announced the first patient was dosed in the Phase 1b arm evaluating ELVN-001 in CML patients who are relapsed, refractory, or intolerant to available TKIs. Learn about our initial proof-of-concept data from the Phase 1a arm here: https://bit.ly/3R5Uv37    

#DYK: Approximately 20% of people with CML switch therapy within the 1st year of treatment and up to 40% switch in the first 5 years of treatment. The majority of treatment switches occur early in the patient’s treatment course due to intolerance or lack and/or loss of molecular response. Join us on April 11th, to learn more about ELVN-001, our candidate for the treatment of CML: https://bit.ly/4cyFSP4

Discover the approach to assessing PBC with Andrea Gossard, APRN, CNP, as she outlines key additional conditions to consider for patients with Primary Biliary Cholangitis. 🎥 https://lnkd.in/enx6VFTQ

Spreading the word about this exciting study!

Definition of Trifascicular Block Trifascicular block (TFB) refers to the presence of conducting disease in all three fascicles: • Right bundle branch (RBB) • Left anterior fascicle (LAF) • Left posterior fascicle (LPF) Incomplete vs complete TFB Trifascicular block can be incomplete or complete, depending on whether all three fascicles have completely failed or not. SIncomplete trifascicular block Incomplete ("impending") trifascicular block can be inferred from one of two electrocardiographic patterns: Fixed block of two fascicles (i.e. bifascicular block) with delayed conduction in the remaining fascicle (i.e. 1st or 2nd degree AV block). Fixed block of one fascicle (i.e. RBBB) with intermittent failure of the other two fascicles (i.e. alternating LAFB / LPFB). • Complete trifascicular block Complete trifascicular block produces 3rd degree AV block with features of bifascicular block. This is because the escape rhythm usually arises from the region of either the left anterior or left posterior fascicle (distal to the site of block), producing QRS complexes with the appearance of RBBE plus either LPFB or LAFB #ecg #medicine #medical

Exciting topic in the world of chronic low back pain (CLBP) treatment! 😊 Pulsed Electromagnetic Fields (PEMF) therapy has been making waves as a non-invasive option for relieving CLBP, showing promise in reducing pain and boosting functionality. 😌 However, recent research sheds light on another contender: Magnetotherapy (MGTH). While initial studies hinted at MGTH's potential, our latest randomized, double-blind, placebo-controlled trial challenges its effectiveness in treating CLBP. Stay tuned as we navigate the evolving landscape of CLBP management and explore innovative solutions together! 💪 https://lnkd.in/dih_E4vQ #CLBP #PainManagement #HealthcareInnovation #pemf #magnetotherapy

Are SGLT2 inhibitors recommended in the treatment of HFmrEF or HFpEF regardless of preexisting DM as in HFrEF? 2021 #ESC heart failure Guidelines made no recommendation for the use of SGLT2 inhibitors in patients with #HFmrEF and #HFpEF. But in 2023 focused update of the 2021 ESC Guidelines, SGLT2i are class I, level A recommendation. #heartfailure #Empagliflozin

Case of the week: how would you treat? We admitted a 63-year-old patient with NSTEMI and posterior wall ischemia. We found an atypical LCA origin from the right valsalava sinus and an occlusion of the RCA. After multiple dilatations of the RCA, there was a large flow-limiting thrombus proximal to the RCA and an occlusion of the RPLD, see my next post. What is your strategy in these cases? I look forward to your comments!

Robust clinical evidence shows that the Vertiflex™ Procedure† is an excellent choice for patients with moderate lumbar spinal stenosis (LSS). The Vertiflex Procedure treats the root cause of pain from LSS by lifting pressure from the nerve roots at the affected segment. Go deeper: https://lnkd.in/gTbKGxqK For indications and disclaimers, visit: https://lnkd.in/gXPP2WpV †Superion™ Indirect Decompression System 

Access these activities to enhance your understanding of haemochromatosis, including key topics like causes of under-diagnosis and misdiagnosis, venesection schedules, treatment monitoring, and more. Learn more: https://bit.ly/3kzDkXh #haemochromatosis #cpd #cme #meded #gp