American Liver Foundation’s Post

Fabien Bonneau will be defending his PhD thesis with a talk entitled "Shape and composition of native mRNA-containing particles isolated from yeast cells" on Friday 12 January 2024 at Aarhus University. During his studies, Fabien Bonneau focused on how messenger RNAs (mRNAs) are packaged together with proteins. mRNAs carry the building plans of all proteins across different compartments within our cells. They are fragile molecules, themselves covered with proteins. Using yeast as a model system, Fabien Bonneau established procedures to isolate native mRNAs together with their protein coat. This material allowed him to identify a network of interactions likely responsible for giving these assemblies a compact shape. The new research findings contribute to the understanding of how mRNAs are packaged into compact particles before travelling within our cells. Read more about his PhD defence: https://lnkd.in/dBgpJ7zh Members of the assessment committee: Professor Françoise Stutz, Department of Cell Biology, Geneva University, Switzerland Professor Peter Brodersen, Department of Biology, Copenhagen University, Denmark Professor Ditlev Egeskov Brodersen (chair), Department of Molecular Biology and Genetics, Aarhus University, Denmark Main supervisor: Professor Torben Heick Jensen, Department of Molecular Biology and Genetics, Aarhus University, Denmark #mRNA #cells #molecularbiology #cellbiology #phddefence #research #university

Excited to share that two Technion PIs were awarded an ERC Advanced Grant! Congratulations to Prof. Jackie Schiller and Prof. Michael Glickman, Technion, for winning the prestigious ERC Advanced Grant, awarded to outstanding PIs by the European Commission. It was a special pleasure working with them on these inspiring and exciting grants, since both were close to heart - they were both in the field of neuroscience. I enjoyed working with both PIs starting from the discussion of the idea, providing feedback on the drafts, and then helping them prepare for the interview. Prof. Schiller's grant, "Dendrite assemblies as the core cortical computation module for continual motor learning," proposes a new hypothesis for how new memories avoid running over older ones, focusing on motor learning. This research has implications for better mechanistic understanding of memory in health and disease, such as Parkinson's disease, as well as AI. Prof. Glickman's grant, "The origin and impact of impaired ubiquitin signaling in the degeneration of neurons," proposes a new hypothesis where ubiquitin malfunction plays a causal role in Alzheimer's disease. This research has implications for better mechanistic understanding of Alzheimer's disease and its causes, and identifying novel therapeutic targets.   Both projects are groundbreaking and ambitious – well deserved! Michael Glickman Jackie Schiller

𝐍𝐞𝐰 𝐫𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐭𝐞𝐚𝐦 𝐰𝐢𝐥𝐥 𝐞𝐱𝐩𝐚𝐧𝐝 𝐨𝐮𝐫 𝐮𝐧𝐝𝐞𝐫𝐬𝐭𝐚𝐧𝐝𝐢𝐧𝐠 𝐨𝐟 𝐭𝐡𝐞 𝐬𝐲𝐬𝐭𝐞𝐦 𝐭𝐡𝐚𝐭 𝐫𝐞𝐩𝐚𝐢𝐫𝐬 𝐝𝐚𝐦𝐚𝐠𝐞 𝐢𝐧 𝐨𝐮𝐫 𝐃𝐍𝐀 As we grow older, damage to our DNA increases due to normal metabolic processes, much like how a car or a piece of clothing that is used daily inevitably deteriorate. This topic will be investigated further by Pablo Alcón: “𝘔𝘺 𝘨𝘰𝘢𝘭 𝘪𝘴 𝘵𝘰 𝘨𝘢𝘪𝘯 𝘯𝘦𝘸 𝘪𝘯𝘴𝘪𝘨𝘩𝘵𝘴 𝘪𝘯𝘵𝘰 𝘵𝘩𝘦 𝘥𝘦𝘵𝘢𝘪𝘭𝘴 𝘰𝘧 𝘩𝘰𝘸 𝘩𝘶𝘮𝘢𝘯 𝘤𝘦𝘭𝘭𝘴 𝘸𝘰𝘳𝘬 𝘵𝘰 𝘳𝘦𝘱𝘢𝘪𝘳 𝘵𝘩𝘦 𝘥𝘢𝘮𝘢𝘨𝘦 𝘵𝘩𝘢𝘵 𝘰𝘤𝘤𝘶𝘳𝘴 𝘪𝘯 𝘰𝘶𝘳 𝘋𝘕𝘈. 𝘉𝘦𝘤𝘢𝘶𝘴𝘦 𝘵𝘩𝘦 𝘣𝘦𝘵𝘵𝘦𝘳 𝘸𝘦 𝘶𝘯𝘥𝘦𝘳𝘴𝘵𝘢𝘯𝘥 𝘵𝘩𝘦 𝘋𝘕𝘈 𝘳𝘦𝘱𝘢𝘪𝘳 𝘴𝘺𝘴𝘵𝘦𝘮, 𝘵𝘩𝘦 𝘣𝘦𝘵𝘵𝘦𝘳 𝘸𝘦 𝘸𝘪𝘭𝘭 𝘣𝘦 𝘢𝘣𝘭𝘦 𝘵𝘰 𝘶𝘯𝘥𝘦𝘳𝘴𝘵𝘢𝘯𝘥 𝘢 𝘯𝘶𝘮𝘣𝘦𝘳 𝘰𝘧 𝘥𝘪𝘴𝘦𝘢𝘴𝘦𝘴. 𝘈𝘯𝘥 𝘵𝘩𝘪𝘴, 𝘪𝘯 𝘵𝘶𝘳𝘯, 𝘸𝘪𝘭𝘭 𝘪𝘯𝘤𝘳𝘦𝘢𝘴𝘦 𝘵𝘩𝘦 𝘤𝘩𝘢𝘯𝘤𝘦𝘴 𝘰𝘧 𝘥𝘦𝘷𝘦𝘭𝘰𝘱𝘪𝘯𝘨 𝘯𝘰𝘷𝘦𝘭 𝘵𝘩𝘦𝘳𝘢𝘱𝘪𝘦𝘴 𝘵𝘢𝘳𝘨𝘦𝘵𝘪𝘯𝘨 𝘵𝘩𝘰𝘴𝘦 𝘥𝘪𝘴𝘦𝘢𝘴𝘦𝘴,” says Pablo Alcón. He will be setting up his own research team at the Department of Molecular Biology and Genetics on 15 August 2024 and conducting research during the next five years. This is made possible by the 2024 Lundbeck Foundation Fellowship, which is worth a total of DKK 10 million (EUR 1.3). Congratulations to Pablo Alcón on securing this grant, bestowed upon five exceptionally talented early-career researchers.   Read the news article: https://lnkd.in/dzyGKh83 Lundbeckfonden / Lundbeck Foundation Aarhus Universitet MRC Laboratory of Molecular Biology (LMB) #molecularbiology #DNA #research #university #DNArepair #DNAdamage #DNArepairsystem #grant #fellowship #LundbeckFoundation #cellbiology #biochemistry #cryoEM #cryogenicelectronmicroscopy #defensesystem #singlemoleculeimaging

Thank you FEBS for awarding me this prestigious fellowship. Looking forward to Join Dr. Darius Kazlauskas labs. My project: integrative approach of AI and metagenomic data for the analysis of CRISPR patterns across healthy and pathological conditions of the human gut. I would also like to Thanks my PhD school European School of Molecular Medicine (SEMM) for their support. #crispr #metagenomic #AI #machinelearning #comoputationalBiology

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🎉 Big Update: 65 New PhD Courses Added to Courses360! 🚀 We're thrilled to announce that we've just expanded our database with 65 new PhD courses from Karolinska Institutet (KI) and University of Gothenburg (GU) for Spring 2025! 🔍 Did you know? With Courses360, you can easily compare similar courses across different universities. Here's a quick example: Course Spotlight: Advanced Cancer Biology - Offered at both KI (Stockholm) and Uppsala University - Same title, different structures and focuses - Use Courses360 to compare duration, content, and more! Why this matters: ✅ Save time researching ✅ Make informed decisions ✅ Discover unique opportunities across institutions Exploring PhD course options in Sweden? Let Courses360 be your guide to finding the perfect fit for your research journey! Check out these new courses #PhDinSweden #ResearchOpportunities #Courses360Update #SwedishUniversities

Two Scripps Research postdoctoral scientists, Divya Bezwada, PhD, and Donté Alexander Stevens, PhD, have been awarded prestigious fellowships by the Jane Coffin Childs Memorial Fund for Medical Research. This honor includes $223,800 in research funding over a three-year period. Bezwada, working in Prof. Ben Cravatt's lab, is exploring allostery, a fundamental biochemical process in protein function. Her research aims to develop new chemical tools to understand allosteric sites and their potential therapeutic applications. In the lab of Asst. Prof. Keren Lasker, Stevens is investigating a novel mode for treating tauopathies, such as Alzheimer’s, by engineering biomolecular condensates to remove tau aggregates in the brain. His work will lay the foundation for next-generation tauopathy therapies. More: https://ow.ly/vFIt50SNs3M

Two School of Medicine faculty were among four Duke faculty members elected to the National Academy of Sciences (NAS) on April 30 in recognition of their distinguished and continuing achievements in original research. David Beratan, PhD, R.J. Reynolds Professor of Chemistry, professor of biochemistry, and professor of physics. Beratan is developing theoretical approaches to understand the function of complex molecular and macromolecular systems. Rich Mooney, PhD, George Barth Geller Distinguished Professor for Research in Neurobiology and professor of cell biology. His broad research goal is to understand the neural mechanisms by which experience guides learning, behavior, and perception. https://lnkd.in/etXWkFH3

Dr Arjuna Ratnayaka is a specialist in retinal cell biology and neurodegeneration at University of Southampton. His doctoral work characterised the molecular/biochemical fate of proteins associated with Age-related Macular Degeneration. He currently has a team of PhD students studying the molecular mechanisms underlying degenerative processes in the retina and brain. #amdawarenessmonth #visionscience #agerelatedmaculardegeneration