American Society of Interventional Pain Physicians (ASIPP) reposted this
Platelet Activation: exogenous vs endogenous activation Platelet activation is vital in hemostasis and tissue repair, essential for both natural healing and therapies like Platelet-Rich Plasma (PRP) for musculoskeletal disorders. Mechanism of Platelet Activation: 1. Shape Change:Platelets morph to increase surface area. 2. Granule Release:Release growth factors like PDGF, TGF-β, VEGF. 3. Surface Receptor Expression: Enhanced receptor expression aids aggregation. 4. Phospholipid Rearrangement:Accelerates clot stabilization. In PRP kits they can be activated endogenously or exogenously Exogenous Activation Exogenous activation occurs outside the body, often in clinical settings for PRP preparation. Blood is drawn, centrifuged to concentrate platelets, and activated by agents like thrombin, calcium chloride, or collagen. This mimics natural activation, releasing growth factors and bioactive molecules that, when injected into an injured area, promote healing and tissue regeneration. If you want to learn more https://lnkd.in/emrdKCap #PlateletActivation #PRPTherapy #RegenerativeMedicine #HealthcareInnovation #KneePainRelief #MedicalResearch
Robert Polofsky
1mo
Very informative
Bob Wright
1mo
Well said!
MD | Pain and palliative care physician certified| Fellowship trained Interventional Pain Management|Family Medicine Certificate | Passionate about Montains 🏃🏾and regenerative medicine
1moGreetings, what is your opinion from the evidence, to activate or not to activate platelets, when yes or when no?