Amgen’s Post

We’ve captured some of the highlights of our Children’s Mercy Research Institute work from the past year in the 2024 Annual Report. Take a look and find out: · The connection between social risk factors and health outcomes. · Ways new technology is accelerating cancer research. · Which programs are paving the way for the next generation of medical researchers. And much more! See the full report: https://cmkc.link/3kIntsE

Check out this intriguing paper, for which I participated as co-corresponding author. It delves into the role of arginase-II in age-associated sarcopenia, inflammation, and immunological responses, which are linked to decreased mobility and muscle degeneration.

Exciting news from The Lily Foundation! We’re delighted to announce the launch of our Research Zone, a vibrant new space designed to showcase the latest advancements in mitochondrial research. Without research, we’ll never find a cure for mitochondrial disease. Watch our video in which our Research Manager, Maria O'Hanlon, PhD, explains why she’s so excited by this project. https://ow.ly/9i7250UBWHh

I am very excited to share my co-first author manuscript investigating the role of the mammalian Hippo kinases, MST1 and MST2, in programmed cell death in mouse macrophages. Our paper details how MST1 and MST2 respond to bacterial pathogens, including Legionella pneumophila and other pathogen-associated death signals to induce lytic and non-lytic cell death. https://lnkd.in/gmpZv9gF

I’m very pleased to have contributed to this publication about the role of tumour microenvironvment in canine splenic haemangiosarcoma together with my colleagues from the University of Perugia and Padua! If you’d like to have a read, here’s the link to the full text.

Matthew Howe, PhD, our principal partnerships manager, presented alongside Elisa L. Priest, Dr.P.H. and Ashley Dowell Hopkins, MBA from Baylor Scott & White Health at the Research and Innovation in Healthcare conference in Dallas, Texas on April 23rd. They discussed the collaboration between BSW and Owkin and how to practically integrate AI-driven methodologies to better understand cardiovascular disease. Learn more about how we work with partners to apply cutting-edge AI to multimodal data to better understand complex biology: https://lnkd.in/eCdTxADH

Researchers at Wilmer Eye Institute, Johns Hopkins Medicine new Visual Mobility Lab, which is part of the Genetic Eye Disease (GEDi) Center at Wilmer, have uncovered new insights into how mobility can be affected by vision impairment, emphasizing the critical connection between vision health and overall quality of life. These findings could pave the way for innovative treatments and interventions! 👓💡https://lnkd.in/evthj3Ne National Alliance for Eye and Vision Research (NAEVR) is proud to support groundbreaking research like this that helps advance our nation's understanding of vision science. Together, we’re supporting vision research and making a difference in people's lives! 🧬👁️

Are all CRFs created equal, or do you need different approaches for different CRFs? Listen to Allison Hubel, PhD, President of the Society for Cryobiology discuss this as the last CryoChats™ entitled: "Assessing Operational Risk and Clinical Impact. ❄ Don't miss the opportunity to engage with industry experts by not registering for the upcoming CryoChats™! Registration is now open: https://lnkd.in/gUXVHa83 Upcoming CryoChats™ Schedule:  7/31 | Cryopreservation Scaling Up 8/28 | Gap Analysis: Inputs & Outputs 9/25 | Reinventing (the Cell Assay) Wheel Dominic Clarke, Marty Giedlin, PhD, Jeffrey D. Allen, John Baust, Marc J. Centrella, Scott Fisher, John Bonham-Carter, Mike O'Mara, Priya Baraniak, Ph.D., Russ Straate, Aby J. Mathew, PhD

Excited to share our paper on using a Velcro-inspired approach for enhancing targeting and accumulation at disease sites! In this study, each dose of the carrier is designed to capture subsequent doses, amplifying targetable surface areas and substantially increasing accumulation at disease sites. Our work demonstrates significant improvements in heart tissue accumulation following myocardial infarction. This work was led by my former PhD student Natalie Jasiewicz, PhD! Check it out here: https://lnkd.in/gd7zSPDN