Amin Marashi, MD’s Post

#LNP #mRNATherapy #metabolicdisease | 𝗖𝗮𝗻 𝗺𝗥𝗡𝗔-𝗟𝗡𝗣 𝘁𝗲𝗰𝗵𝗻𝗼𝗹𝗼𝗴𝘆 𝘂𝗻𝗹𝗼𝗰𝗸 𝗻𝗲𝘄 𝘁𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁𝘀 𝗳𝗼𝗿 𝗼𝗯𝗲𝘀𝗶𝘁𝘆, 𝗱𝗶𝗮𝗯𝗲𝘁𝗲𝘀, 𝗮𝗻𝗱 𝗹𝗶𝘃𝗲𝗿 𝗱𝗶𝘀𝗲𝗮𝘀𝗲𝘀 𝘂𝘀𝗶𝗻𝗴 𝗜𝗟-𝟮𝟮? Interleukin (IL)-22 is a promising therapeutic protein for obesity, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease due to its hepatoprotective effects. However, its short serum half-life has limited clinical use. Enter mRNA-Lipid Nanoparticle (LNP) Technology! This innovative approach enables the body to produce IL-22 fusion protein, overcoming previous limitations. Researchers at #moderna Susanna Canali, Alexander W. Fischer, Mychael Nguyen, Karl Anderson, Lorna Wu, Anne-Renee Graham, and their team investigated the effects of mRNA-LNP encoding IL-22 on metabolic disease in various mouse models, showing significant potential for future treatments. Stay tuned for more on this groundbreaking research! For more check out here: https://lnkd.in/eetsDShz #MetabolicDisease #IL22 #Biotech #MedicalResearch #Innovation

🚀 Exciting News! 🚀 I’m pleased to share that our latest research paper titled "The Impact of PAD4-dependent Neutrophil Extracellular Trap Formation on the Early Development of Intestinal Fibrosis in Crohn's Disease" has been published in the Journal of Crohn's and Colitis and is now available on PubMed! You can read the full paper here: https://lnkd.in/e2ugyaRE. In this study, we explored how PAD4-dependent neutrophil extracellular traps (NETs) might contribute to the early stages of intestinal fibrosis in Crohn’s Disease (CD). Our findings suggest that NETs can activate fibroblasts via the TLR2/NF-kB pathway, potentially driving fibrosis. Inhibition of PAD4 could therefore be a promising strategy to modulate both inflammation and fibrosis in CD. I’m grateful to have been part of this research team, and I’d like to extend my thanks for the collaboration. Gabriele Dragoni Bo-Jun Ke Bram Verstockt Gianluca Matteoli Kim Martinod Tommaso Innocenti Severine Vermeire #Research #CrohnsDisease #Fibrosis #NeutrophilExtracellularTraps #IBD #Inflammation #JCC

🔬 Exciting Research Alert! 🔬 A groundbreaking study aims to identify biomarkers for Inflammatory Bowel Disease (IBD), a chronic condition affecting over 540,000 people in the UK. This research is a significant step towards personalized medicine, aiming to develop more targeted and effective treatments for IBD patients. Understanding specific biomarkers associated with IBD will pave the way for tailored therapies, improving patient outcomes and quality of life. Stay tuned for more updates on this innovative research! For more details, check out the full article here: https://lnkd.in/gWxp28zD #IBD #PersonalizedMedicine #Healthcare #MedicalResearch #Biomarkers #Innovation #PatientCare #ChronicIllness #HealthScience

Great article 📖 on mitochondrial therapeutics by Roohi Mariam Peter including quotes from our CEO Neil Miller and an overview of our #mPTP targeting therapeutics for #neurologicaldisorders #AML #MND #Parkinsons To find out more about our breakthrough science visit www.nrgtherapeutics.com

Experts are asking whether the study and treatment of myeloproliferative neoplasms (MPNs) is ready for a new era with new end points, with data that show how survival benefits are biologically linked to changes in the spleen, reduction in fibrosis, or other responses. Learn more! #MyeloproliferativeNeoplasms #MPNStudy #SurvivalBenefits

#PaperoftheDay: "Leukocyte telomere length and attrition in association with disease severity in cystic fibrosis patients" DOI ⬇️ https://lnkd.in/e2vuHP35 #cysticfibrosis #telomere #aging #research #openaccess #publishing

Wouldn't it be great if there were a magic number for predicting the risk of any potential disease according to our genomic information? This sounds like a movie, but I think this is what PRS (Polygenic Risk Scores) aim to achieve. By screening the genomic variants, researchers can predict certain disease development. Sounds crazy. Lennon, N.J., Kottyan, L.C., Kachulis, C. et al. Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations. Nat Med 30, 480–487 (2024). https://lnkd.in/evGFZ8XE

⚡ Famously known as the powerhouse of the cell, the mitochondria is responsible for generating most of the energy that fuels reactions that take place in cells. That’s why if this organelle does not function properly, it could lead to a number of diseases. Various biotechs are working to restore mitochondrial balance to fight disease. ⚖️ Labiotech spoke to Vandria SA’s Pénélope Andreux and NRG Therapeutics’ Neil Miller about the different ways to target the mitochondria to treat conditions like neurodegeneration and even metabolic diseases. 🎯 Read our latest article to find out more! 👇 https://lnkd.in/dUh2_wDj #mitochondria #biotech #diseaseresearch #metabolicdiseases #biotechinnovation #healthcare #pharmanews #biopharma #drugdevelopment

"To understand immune dysregulation in ME/CFS, we use single-cell RNA sequencing (scRNA-seq) to examine immune cells in patient and control cohorts. Postexertional malaise (PEM), an exacerbation of symptoms following strenuous exercise, is a characteristic symptom of ME/CFS. To detect changes coincident with PEM, we applied scRNA-seq on the same cohorts following exercise. At baseline, ME/CFS patients display classical monocyte dysregulation suggestive of inappropriate differentiation and migration to tissue. We identify both diseased and more normal monocytes within patients, and the fraction of diseased cells correlates with disease severity. Comparing the transcriptome at baseline and postexercise challenge, we discover patterns indicative of improper platelet activation in patients, with minimal changes elsewhere in the immune system. Taken together, these data identify immunological defects present at baseline in patients and an additional layer of dysregulation in platelets." *note: PEM can already happen after minor physical,, cognitive, sensory or emotional exertion. Not just strenuous exercise. https://lnkd.in/esEE6q72 #pwme #myalgicE

🌟 News Alert: Advancing Liver Health! 🌱 Exciting strides in liver regeneration research are here! 🚀 A groundbreaking study sheds light on the intricate mechanisms triggering liver regrowth after damage, bringing us one step closer to reversing liver failure. 🔬 This pioneering research uncovers key insights into how the liver responds to injury, revealing promising avenues for developing novel therapies for liver diseases. Understanding these regenerative processes opens doors to innovative treatments and holds immense potential for patients worldwide. 💡Read more at https://lnkd.in/gKmep4Um #LiverHealth #MedicalResearch #LiverRegeneration #HealthcareInnovation #LiverDiseases #BreakthroughResearch