AnaBios Corporation’s Post

We're still accepting abstracts for our Translational Research Grant, with the winning academic scientist awarded $15,000 in tissue samples to advance their #translationalresearch project. Learn more about the grant and submission guidelines on our website. Submission deadline is June 30. #DrugDiscovery #HeartResearch #PainResearch #Toxicology #EarlyHumanInsights

The 4th Annual AnaBios Translational Research Grant is now open for abstract submissions. The winning scientist will receive $15,000 in tissue samples to propel their translational research project forward. Explore more about the grant and submission guidelines on our website. #TranslationalResearch #DrugDiscovery #HeartResearch #PainResearch #Toxicology

We're accepting abstracts for the 4th Annual AnaBios Translational Research Grant. The award of $15,000 in high-quality human tissue samples will help the winning academic #researcher advance his/her translational research project. To learn more details about the grant, including how to submit an abstract, visit our website. #drugdiscovery #heartresearch #painresearch #toxicology #translationalresearch

AnaBios is accepting abstracts for the 4th Annual AnaBios Translational Research Grant. The award of $15,000 in high-quality human tissue samples will help the winning academic #researcher advance his/her #translationalresearch project. To learn more details about the grant, including how to submit an abstract, visit our website. #drugdiscovery #heartresearch #painresearch #toxicology

Determining the appropriate dosing regimen and predicting ADC behaviour in humans is crucial to their clinical success. Challenges include: -Understanding the interplay between the antibody, linker, and cytotoxic payload & accurately predicting how the ADC will distribute and release the drug in target tissues versus non-target tissues -The need for special considerations for dose- and exposure-response analyses given the selectivity of the antibody and the potency of the cytotoxic payload - Navigating the requirement for more rational dose optimization strategies off the back of Project Optimus guidelines which may be more time consuming & costly, particularly for smaller biotechs As the ADC Pharmacokinetics & Clinical Pharmacology Summit will unpack these challenges in under a month, I wanted to highlight a final opportunity to save up to $350 on registration, expiring this Friday (09/13) Register HERE: https://ter.li/5uu6ht Our industry-leading speaker faculty includes: Alison Betts, Doug Leipold, Faye (Zufei) Zhang, Frank Christian Dr. Richard, Hsuan Ping Chang, Ilse De Salve, Jeff Kearns, Jianzhong Wen, Li Li, Michael Z. Liao, PhD, MLS, Niyanta Kumar, Rajeev Menon, Sandhya Girish, Seema K., Venkatesh Pilla Reddy, Xiaogang Han, Yuting Wang, Ph.D, Zuzana Antosova Looking forward to meeting everyone in Boston! 😊

Modeling and simulation approaches, including Quantitative Systems Pharmacology (QSP), can help address challenges in Alzheimer’s Disease drug R&D, such as complex disease mechanisms, patient variability, and clinical trial design. Connect with our experts, Hugo Geerts and Sarah DiBartolo, and view our posters at AAIC 2024 to learn how QSP can help provide deeper understanding of Alzheimer’s Disease and optimize the development of new therapies.     Certara's posters at AAIC 2024: - QSP Model for Therapies Targeting Aβ and Tau Pathologies in Alzheimer’s Disease (In collaboration with Biogen)  - Exploring biological response profiles to amyloid antibodies in clinical practice using QSP - Towards predicting individual cognitive trajectories in AD using QSP Learn more and register: https://lnkd.in/eHvHWhm3 #QuantitativeSystemsPharmacology #QSP #DrugDevelopment #AlzheimersDisease #AAIC24

Registration for our upcoming webinar titled "High-Content Modeling of Human Tissues and Diseases in vitro for Precision Drug Screening" is now open. Secure your spot to learn the latest trend in the use of microphysiological systems for precision drug discovery. https://lnkd.in/eFnsNg4W #aaps #precisionmedicine

Registration for our upcoming webinar titled "High-Content Modeling of Human Tissues and Diseases in vitro for Precision Drug Screening" is now open. Secure your spot to learn the latest trend in the use of microphysiological systems for precision drug discovery. https://lnkd.in/eFnsNg4W #aaps #precisionmedicine

Happy #WorldOrganoidResearchDay! 🧠🔬 Today, we honor the potential of #organoids—tiny clusters of cells that mimic the structure and function of specific organs. These 3D cell models have opened up new avenues in medicine and scientific research. 📖 In our latest mini-review, we delve into the predictive power of organoids in drug discovery. From performance in recent drug evaluation studies to best practices for optimizing organoid-based models, it’s a must-read. By recapitulating key features of the represented organ, organoids are our window into the intricate world of human biology. Let’s celebrate their impact! 🙌

Organoid co-cultures and organ-on-a-chip (OoC) systems are advanced in vitro models that further enhance the physiological relevance of organoids by incorporating a broader array of tissue components compared to conventional organoid cultures. Read this mini review to learn about the Predictive Power of Organoids in Drug Discovery and see key takeaways below: - Although immortalized cell lines and animal models are useful for many applications in drug discovery, they are limited by their reductive and cross-species characteristics, respectively, which affect their ability to predict human in vivo responses with sufficient accuracy. - Organoids are high-fidelity biological models that can recapitulate the cellular structure and function of specific organs, can be expanded and stored for long periods, and are compatible with a wide range of assays, including high-throughput screening. - Organoids have demonstrated predictive power with notable sensitivity and specificity in recent drug evaluation studies. - Incorporating human stem cells or stem cell-derived organoids into complex systems such as co-culture and OoC systems is a powerful way to closely model metabolic, transport, and other physiological cellular characteristics of the tissue of interest, maximizing the predictive value of these systems for drug discovery research.