Assistant Professor | Passionate Scientist | Principal Investigator | Editor | Leadership | Data Analytics | Multi-omics
Our research provides crucial insights into pancreatic ductal adenocarcinoma (PDAC). Hypoxia, a defining characteristic of PDAC, correlates with disease severity, influencing treatment response, invasiveness, and immunosuppression. Utilizing the Buffa gene signature, we pinpointed LGALS3 as a pivotal gene linked to high hypoxia levels. Elevated hypoxia is associated with reduced levels of T cells, NK cells, and dendritic cells, along with increased immunosuppressive molecules. These findings propose innovative strategies for advancing PDAC immunotherapy by targeting both hypoxia and specific immune elements. Kudos to the team's exceptional work, particularly acknowledging Hassan Sadozai's contributions. https://lnkd.in/es9rQuXv #pancreaticcancer #immunology #immunotherapy #teamcollaboration #teameffort #cancertreatment #cancerresearch #medicaladvancements #transcriptomics #collaborations #interdisciplinary #leadership #leadershipdevelopment #machinelearning
Hearty congratulations on this insightful work!
Thank you Animesh Acharjee! Your collaboration, expert insights and input notably enhanced the quality and the impact of this work. Hope for many more fruitful collaborations in the future!