Ansa Biotechnologies, Inc.’s Post

DNA contains molecular information encoded in both genetic and epigenetic bases, essential for understanding biology. However, interrogating both of these informational layers simultaneously has traditionally been challenging. With the recent introduction of duet multiomics solution evoC, which uniquely reads genetic and epigenetic cytosine modifications, this challenge has been overcome. Read more about it in our tech note “Using UMIs with duet multiomics solution evoC reduces sequencing requirements and increases coverage” here: https://lnkd.in/gYWnagRv.. biomodal, #sequencing, #evoC, #epigenetics

Excited to announce my new publication in the Journal of Computational Biology titled "A Rigorous Framework to Classify the Postduplication Fate of Paralogous Genes." In this work, we delve into the dynamics of post-duplication fates, exploring how these fates evolve over time, the impact of the number of descendants, and the role of the environment in shaping these outcomes. Check out the full study for an in-depth analysis! https://lnkd.in/e5KJFsjX #bioinformatics #algorithms #computational_biology #duplication_fates

CRISPR–Cas systems are adaptive immune mechanisms in bacteria and archaea that protect against mobile genetic elements. These systems go through three phases: adaptation, expression, and interference. The interference stage involves the Csy complex and Cas2/3, which work together to detect and cleave invading viral genomes. Specifically, the Csy complex binds to invading genetic elements, forming the Csy–double-stranded DNA complex. Cas8f undergoes conformational changes within this complex to recruit Cas2/3, leading to the degradation of the genetic element. However, in the type I-F CRISPR–Cas system encoded by phage ICP1, Cas8f lacks the helical bundle domain present in other systems, raising questions about how the Csy complex of ICP1 recruits Cas2/3 without this domain. https://buff.ly/3zxfBBE

I am happy to share that our latest results got published in BMC Genomics. I am also very grateful for the possibility. This publication can be considered as a milestone in the life of our laboratory since this article is the first one that does not contain wet lab work just pure in-silico research. https://lnkd.in/d5TQPSxy #bmc #bioinformatics #molecularbiology #machinelearning

🌟 Exploring the Evolution of DNA Research: From Miescher to CRISPR-Cas9 🌟 DNA research has revolutionized our understanding of life, enabling breakthroughs that seemed impossible just decades ago. I recently came across a fascinating timeline that charts the major milestones in DNA research, from Friedrich Miescher's discovery of nucleic acid in 1869 to the groundbreaking development of CRISPR-Cas9 by Emmanuelle Charpentier and Jennifer Doudna. 🔬 Key Highlights: -1869:Friedrich Miescher identifies "nuclein," now known as DNA, laying the foundation for molecular biology. - 1953: Watson and Crick, building on Rosalind Franklin's X-ray diffraction data, unveil the double-helix structure of DNA. - 1977: Sanger sequencing allows us to decode the exact sequence of DNA, revolutionizing genomics. - 2012:CRISPR-Cas9 technology emerges, offering unprecedented precision in gene editing, opening doors to new treatments and possibilities in medicine. Each step in this timeline has been a leap forward, contributing to the powerful tools we have today in biotechnology and microbiology. This resource is a great reminder of the importance of each discovery in shaping the future of science. 🔗 Check out the full timeline here: [History of DNA] (https://lnkd.in/eaAHTfiw) #Microbiology #Biotechnology #DNA #CRISPR #ScienceHistory #Research

🚸 Interesting article investigates meiotic recombination dynamics in plants with repeat-based holocentromeres, focusing on Rhynchospora breviuscula. 🚸 Meiotic recombination, initiated by DNA double-strand breaks, leads to the exchange of genetic material between homologous chromosomes, 🚸 Centromeres play a crucial role in genomic architecture and recombination dynamics, affecting crossover (CO) distribution. 🚸 Despite diffused centromeres in R. breviuscula, CO frequency shows a distal bias. 🚸 Crossovers are absent inside centromeric units but not in their proximity, suggesting a non-canonical centromere effect. 🚸 Telomere-led synapsis of homologues is proposed as the primary determinant of CO distribution. 🚸 The study highlights the importance of mechanistic features of meiotic pairing and synapsis over genomic features and centromere organization in shaping CO distribution. 🚸 The 'coarsening' model, involving HEI10 loading, fits observed CO patterns. 🚸 Telomeres harboring 35S rDNA exhibit low recombination frequencies due to late synapsis and HEI10 loading. 🚸 Haplotype-phased genomes and scRNA-seq enable investigation of CO frequencies in gametes. 🚸 While CO bias resembles other eukaryotes, correlation with (epi)genetic features is limited in R. breviuscula. 🚸 COs preferentially form within gene promoters, suggesting fine-scale regulation associated with open chromatin states. 🚸 The absence of a centromere effect is attributed to closed chromatin states of centromeric chromatin, indicating a potential strategy to address meiotic recombination in monocentric chromosomes. Like and share the knowledge :) Dr. Hamed Altaweel #meiosis #genetics #plants

The ability to design, build, and implement chromosomes is revolutionizing current approaches to understanding and manipulating genetic information. By converging biology and technology, synthetic chromosomes unlock enormous potential for genetic engineering, precision medicine, and beyond. The Sc2.0 Project is a global collaboration to synthesize the world’s first synthetic eukaryotic genome. Most recently, researchers here at SynCTI published the redesign and construction of synthetic Chromosome XV (synXV), the second largest chromosome of the yeast Saccharomyces cerevisiae genome. To overcome the challenges of building an extremely large chromosome, the team developed a method to expedite large chromosomal DNA exchanges at specific sites engineered into SynXV. Not only did this approach enable the concurrent assembly of multiple chromosomal segments, it also allowed further recombination of synXV with other chromosomes to generate different genetic combinations, shedding light on the association of genetic variation and phenotype, or expressed traits. We are thrilled to share this work! Check out the work here: https://lnkd.in/gXGZUhWZ Media coverage: https://lnkd.in/g2A27MfN https://lnkd.in/gWMntevk

Check out this latest groundbreaking developments at NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI) 💡

The impact of Cryo-EM on structureomics is tremendous, and this review offers an informative overview. Structureomics aims to create a comprehensive 'structureome,' detailing molecular models for nearly every protein across various genomes ( https://lnkd.in/gtYzZDW8 ). While experimental validation and accounting for dynamic protein structures are necessary, the structureome provides a deeper understanding of cellular states beyond gene sequences or expression levels. This advancement is revolutionizing structural biology, allowing researchers to explore molecular intricacies with unparalleled precision. Read this article… it's freely accessible! Did you know... our cutting-edge Cryo-EM services, alongside our exceptional expertise, are the key factors behind our clients' continuous project successes? Revolutionize projects with Helix and Cryo-EM. Call us! (https://loom.ly/XFNYiNI) #cryoem #crystallization #crystallography #drugdiscovery #drugdesign #protein #proteins #dna #rna #antibody #antibodies #science #nature #research #bio #bionetwork #biotechnology #biotech #bioscience #biotechnologyindustry #biopharma #drugdesign #drugdevelopment #pharmaceuticals #pharma #drug #lifesciences #lifescience

On April 25th, people around the globe come together to commemorate World DNA Day, a day dedicated to the discovery of the double helix structure of DNA by James Watson and Francis Crick in 1953. This groundbreaking revelation paved the way for countless advancements in genetics, medicine, and biotechnology. World DNA Day serves as a reminder of the profound impact DNA has had on our understanding of life itself. It's a day to celebrate the marvels of genetic code, which holds the blueprint for all living organisms. From the sequencing of the human genome to the development of gene editing technologies like CRISPR, DNA continues to revolutionize science and medicine, offering insights into our origins, health, and identity. Beyond its scientific significance, World DNA Day also highlights the ethical and societal implications of genetic research. It prompts discussions on privacy, consent, and the responsible use of genetic information. It underscores the importance of ensuring that advancements in genetics are used for the benefit of all humanity, with careful consideration given to ethical guidelines and regulations. As we celebrate World DNA Day, let us reflect on the incredible journey of discovery that has brought us to where we are today. Let us recognize the potential of DNA to shape our future and inspire us to continue exploring its mysteries for the betterment of society. #exatusgene