MicroRNA-451a: A Potential Therapeutic Avenue Against Gemcitabine-Resistant Biliary Tract Cancers The study investigated miR-451a's impact on gemcitabine-resistant biliary tract cancers (BTCs), highlighting its significant inhibition of proliferation and induction of apoptosis in gallbladder cancer (GBC) and cholangiocarcinoma (CCA) cells, including those resistant to gemcitabine. Through its suppression of chemoresistant traits and regulation of the PI3K/AKT pathway by targeting macrophage migration inhibitory factor, miR-451a emerged as a promising therapeutic avenue for addressing gemcitabine-refractory BTCs. Employing 3D cell culture systems and GBC organoids, this research underscores the potential of miR-451a supplementation as a viable strategy against resistant BTCs. Read more: https://lnkd.in/d4YuFpbt #Ariti #Cancer #Research #resistance #Study #univeristy #people #peoplefirst #pharmaceuticals #health #healthcare #medical #carcinoma #oncology #therapy
