Association for Single Cell Analysis (ASCA)’s Post

Did you know cells can "talk"? 🔬 Dr. Gregory Reeves' live imaging research has revealed that cells communicate and activate a memory mechanism, sustaining gene expression over time. This discovery sheds light on how the Bone Morphogenetic Protein (BMP) pathway—responsible for gene transcription—evolves, influencing cellular decision-making across various tissues. Learn more: tx.ag/cellmemory

📍 Inferring spatially informed transcription factor activity across cellular contexts Zhang et al. presented STAN, a linear mixed-effects computational method that predicts spot-specific transcription factor (TF) activities by integrating curated TF-target gene priors, mRNA expression, spatial coordinates, and morphological features. ➡️ More details: https://lnkd.in/e7AMsS9Z #UniversityofPittsburgh #spatialomics #spatialbiology #singlecellanalysis #singlecell

🔹 Genetic programs activating proregenerative states in nonmyocyte cells Dong et al. delineated the chromatin landscapes of the noncardiomyocytes of the regenerating heart at the single-cell level.   Key findings 🔹 The cis-regulatory architectures and trans-acting factors controlling cell type-specific gene expression programs 🔹 A critical role of activator protein 1 (AP-1) in inducing epicardial cell/fibroblast formation and endocardial cell activation through physical interaction with Yap1/Tead and Stat ➡️ More details: https://lnkd.in/eMesEdkC #universityofnorthcarolina #spatialomics #spatialbiology #singlecellanalysis #singlecell

Progressive supranuclear palsy (PSP) is a neurodegenerative disorder with movement symptoms that rapidly worsen and lead to life-threatening complications. In three different species, NIA-funded researchers examined how PSP influences gene expression in specific types of brain cells. The experiments and analysis discovered three genes — DDR2, STOM, and KANK2 — as possible therapeutic targets. Read more about the study and how to access publicly available data: https://lnkd.in/eQfE3HcC #NIAFunded #NIHAging #Genes #ProgressiveSupranuclearPalsy

Whether you are attending ASGCT in person or virtually, you’ll want to sit in on our presentation titled “Validating EPI-321 Safety for FSHD: A Comprehensive Off-target Characterization Platform for Epigenetic Gene Therapies” where Epic Bio scientist, Linsin Smith, PhD., will showcase our pioneering work in establishing the standard for off-target characterization in epigenetic editing. Read the abstract here: https://ow.ly/cgEn50RtYmH #EpicBio #ASGCT2024 #GeneticMedicine #epigenetics

Headed to #ASGCT2024? Meet the Form Bio team at booth #729 to learn how AI can optimize gene therapy construct designs for faster delivery to market with a higher probability of success. Pre-book a scientific consultation and learn more about our conference program, including workshops, symposia, and abstract presentations at our event page: https://hubs.li/Q02t5djn0 #cellandgenetherapy #genetherapy #AAV #AI

Single cell analysis can unlock new levels of your cellular research by providing insight into cell heterogeneity, cell expression profiles, disease mechanisms, and unique cellular dynamics leading to advancements in basic biological research and potential clinical applications of your work. The #BDBiosciences #Rhapsody Single Cell Analysis System can do just that. The Rhapsody can help to identify and characterize rare cell populations, transitional states, and cellular subtypes within a larger population, identify key genes, pathways, and cellular interactions involved in disease progression and can help identify dynamic changes in gene regulation. With the purchase of the Rhapsody at #fisherscientific you can redeem an analysis kit at no additional cost for saving from $1,000 to $3,000. Ask me how. https://lnkd.in/g69ma9kS #singlecell #singlecellanalysis #cellbiology #cellculture #geneexpression

A key PWS gene, SNORD116, interacts with the protein-making machinery (ribosomes) in mouse neurons. A new study will determine whether the gene works similarly in human neurons, and how loss of SNORD116 changes the cell. https://fpwr.us/3xWvYHh

Optimizing your cryopreservation processes may help improve cell viability and other practices in your lab. Journey with us through a "Cryopreservation Best Practices" infographic we developed in collaboration with Cell & Gene Therapy Insights and BioInsights. Highlights: • Sample isolation and cell processing • Formulation • Fill • Freezing the sample • Storing the sample • Shipping the sample • Thawing the sample View it here: https://ow.ly/fMM550Roh85 #cryopreservation #cellprocessing #cellfreezing #coldchain #cellthawing

Have you claimed your FREE Biopreservation Best Practices poster yet? Our blog post discussing how to tackle cryopreservation challenges contains a link where you can request a free printed poster for your laboratory. The blog reviews sample isolation/cell processing practices all the way through to the end step – thawing. What’s not to love about sharing and reinforcing best practices?! Spread the word with your fellow scientists and colleagues. Request your poster: https://lnkd.in/ehexu-Qp (Infographic poster created in collaboration with Cell & Gene Therapy Insights and BioInsights.)