Atlas Antibodies’ Post

🛫 For all who travel to Anaheim this week to attend #ASMS2024, safe travels and enjoy the conference. 🎁 While at the conference, please make sure to check out the following posters to learn about cool MALDI Imaging and MALDI HiPLEX-IHC applications and the capabilities of #SCiLSLab: WP370 - Combination of Fluorescence and IR Images with Protein and Lipid MALDI Imaging Allows Insight into Disease Phenotypes THP419 - Integration and Joint Multivariate Analysis of Multimodal Chemical Imaging Data of Hepatocellular Carcinoma in Rat THP456 - iprm-PASEF: an Integrated Workflow for the Analysis and Interpretation of Spatial On-Tissue Tandem Mass Spectrometry of Lipids THP 457 - Deep Molecular Coverage at Faster Throughput: IR Guided MALDI Imaging in Cancer Research

Jellyfish-Inspired Microchip Can Be Used to Capture Cancer Cells Scientists have built a jellyfish-inspired microchip that can capture cancer and other rare cells in human blood. The scientists published their findings in the journal Proceedings of the National Academy of Sciences. Jellyfish capture food particles with their long tentacles, which are equipped with repeating patterns of sticky structures. Researchers at Brigham and Women’s Hospital in Boston used that design to build a microfluidic chip coated with long strands of repeating DNA sequences that bind to specific proteins or cancer cells as they float by in the blood. Learn more https://lnkd.in/dtcVJeh6

Don’t miss out on our latest webinar focused on discoveries in pan-cancer markers. 👉 Check out our webinars now: https://ow.ly/cvpS50RZPus #CancerResearch #Webinar #PanCancerMarkers #ScientificDiscovery #OncologyResearch #atlasantibodies #primaryantibodies

Made this illustration of the small molecule pathway against UVA-radiation damage to prevent the development of skin cancer. Publication link can be found in last: Fatima, N., Yaqoob, S., Rana, S., Hameed, A., Mirza, M. R., & Jabeen, A. (2024). In vitro photoprotective potential of aryl-sandwiched (thio)semicarbazones against UVA mediated cellular and DNA damage. Journal of Photochemistry and Photobiology B Biology, 251, 112841. https://lnkd.in/ewJbu3UX https://lnkd.in/esysMste

At the 10th Anniversary of Oxford Nanopore Technologies London Calling, Dr Carika Weldon, MRSB, FIBMS Weldon presented a pilot study on Medicine for Breast Cancer in the Caribbean, using Geneyx Genomex Ltd. Analysis solution for tertiary NGS analysis. Some highlights from the pilot: - Research is being done to identify unique genetic markers for Caribbean women. - Oxford Nanopore Technologies is being used for local, end-to-end testing in Bermuda. - 40% of cases test positive for BRCA1/BRCA2, while 60% test negative, highlighting the need for expanded testing. Find out more here: https://lnkd.in/eSZKH7kP #wgs #ngs #londoncalling #breastcancer #brca

Missed yesterday's #MicroscopyMasters webinar? We've got you covered 😎 🔬 Extracellular Vesicles (EVs) are membrane-bound nanoparticles essential for cell-to-cell communication. 👩🔬 In this #Microscopy Masters #Webinar, Allaura Cone, PhD from the Lineberger Comprehensive Cancer Center delves into the intriguing findings unearthed by the Dittmer Lab. 📄 The Dittmer Lab has published multiple papers (McNamara et al, JEV, 2022, and Zhou et al, JEV, 2023) using ONI's Nanoimager to analyze the protein content in EVs. Interestingly, they discovered, using both Cryogenic Electron Microscopy (Cryo-EM) and dSTORM, that EVs seem to have both lipid-enriched and protein-enriched microdomains. They aim to explore this phenomenon further using 3D dSTORM. Watch the recording now! ➡️ https://hubs.li/Q02mtKwZ0 #ExtracellularVesicles #dSTORM #SuperResolution

Brilliant ! "The motive for this project comes from the disparity between breast cancer rates and deaths between European and non-European populations; 9 of the top 10 countries getting breast cancer are European, but all the top 10 countries dying from breast cancer are non-European. Four in ten of these are Caribbean, with Barbados the highest.   Looking at traditional breast cancer genetic testing methods in the Caribbean, 13% of diagnoses of known genes were not BRCA1 or BRCA2, therefore there is a need to offer broader panel-based testing, including, but extending beyond these genes. Further, as most genetic testing is sent abroad from the Caribbean, the need was identified to repatriate testing. As part of the project, CariGenetics delivered end-to-end testing locally in Bermuda, using Oxford Nanopore Technology, as the first certified ONT Service Lab for PromethION in LATAM & Caribbean region." Oxford Nanopore Technologies #genomics #genetics #geneticdiagnosis #cancer #oncology Geneyx Genomex Ltd. #Longread #breastcancer #geneticdiversity CariGenetics #wgs

Profiling colon cancer EVs by proteomics: in their latest work, Aleksander Cvjetkovic, Jan Lötvall and collaborators at Sahlgrenska Academy at University of Gothenburg isolated extracellular vesicles from tumor tissue and healthy mucosal tissue, and subsequently performed quantitative proteomic analysis. They found that variations in proteomes between healthy and cancerous tissue underscore the significance of the interstitial vesicle secretome as a key contributor to disease progression https://lnkd.in/ePFcN88f also authored by Nasibeh Karimi, Rossella Crescitelli, Annika Thorsell, Helena Taflin and Cecilia Lässer #extracellularvesicles #exosomes #proteomics #coloncancer #Vesiculab

We're thrilled to announce the publication of our latest paper on AI-driven biomarkers in bone marrow. It's been great collaborating with Roche and the University of Oxford on this research into anti-fibrotics! Our deep learning models quantitatively measured disease-modifying response in the bone marrow of inflammatory disease. Check out our paper to learn more about how we're leveraging AI to make a difference in hemato-oncology. #AI #DeepLearning #BoneMarrow #Haem #AntiFibrotics #EHA2024

Centromere structure and chromosome segregation errors Researchers made a surprising new discovery in the structure of the centromere, a structure that is involved in ensuring that chromosomes are segregated properly when a cell divides. Mistakes in chromosome segregation can lead to cell death and cancer development. The researchers discovered that the centromere consists of two subdomains. This fundamental finding has important implications for the process of chromosome segregation and provides new mechanisms underlying erroneous divisions in cancer cells. Understanding the structure of the centromere can contribute to more insights into the function of the centromere and its role in erroneous chromosomal segregation. To investigate the centromere structure, the researchers used a combination of imaging and sequencing techniques. Previously believed to consist of a compact structure attaching to multiple spindle microtubules, it was instead revealed that the centromere consists of two subdomains. #ScienceMission #ScienceNewsHighlights https://lnkd.in/gjEeQv9y