DOTA PEG https://lnkd.in/gj4QuzGX DOTA PEG linkers are an important class of molecules widely used in pharmaceutical research and development. These linkers are composed of a DOTA chelator and a polyethylene glycol (PEG) chain. The DOTA moiety is used to bind to metal ions such as copper, gallium or lutetium, while the PEG chain provides stability and solubility to the resulting conjugate.
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𝗕𝗼𝗿𝗼𝗻-𝗖𝗼𝗻𝘁𝗮𝗶𝗻𝗶𝗻𝗴 𝗕𝘂𝗶𝗹𝗱𝗶𝗻𝗴 𝗕𝗹𝗼𝗰𝗸𝘀 𝗳𝗼𝗿 𝗠𝗲𝗱𝗶𝗰𝗶𝗻𝗮𝗹 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵: 𝗕𝗲𝗻𝘇𝗼𝘅𝗮𝗯𝗼𝗿𝗼𝗹𝗲𝘀 Boronic acids are recognized as useful scaffolds for pharmaceutical compounds, due to their unique property to form a reversible covalent bond at the boron center with various nucleophilic functional groups. TCI can offer a wide range of benzoxaboroles with various functional groups on each benzene ring useful for further derivatizations and we also can provide custom synthesis of derivatives including bulk synthesis. 𝗟𝗲𝗮𝗿𝗻 𝗠𝗼𝗿𝗲: https://lnkd.in/gSfn7tGK #bulksynthesis #customsynthesis #pharmaceuticalcompounds #benzoxaboroles #medicinalresearch #boronicacids #researchchemicals #reagents
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Ph.D. Research Scholar, IIT BHU, Department of Pharmaceutical Engineering and Technology
I'm happy to share my first review article titled as "Liraglutide innovations: a comprehensive review of patents (2014–2024)" in the journal of Pharmaceutical Patent Analyst, Taylor and Francis. Special thanks to my supervisor Prof.Amit Kumar Goyal. In this article I've mentioned all the patents published related to Glucagon-like peptide-1 agonist "liraglutide". Read the full article here: https://lnkd.in/dXppUsUx
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Metal-free synthesis of heterocycles is highly sought after in the pharmaceutical industry and more so when the heterocycle happens to be a "Pyridine" ring. A new method reports a radical 6-endo addition method for pyridine synthesis from cyclopropylamides and alkynes wherein various terminal and substituted alkynes can be inserted as C2 units into cyclopropylamides to synthesize versatile pyridines to suit the late-stage pyridine installation on complex molecules. The reaction is amenable to easily scale up with excellent functional group compatibility while avoiding the headache of eliminating the need to remove trace metal catalysts from the reaction. https://lnkd.in/gBYvDQex
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Doctoral Research Student/Chemical Engineering/IIT-Tirupati/ M.tech @ Puducherry Technological University/ EX-GAT-Chemical@NLC India ltd/B.Tech @PEC.
I am happy to inform my paper has been accepted in fluid phase equilibria "UNIFAC and Wilson Models to Correlate Solubility of Pharmaceutical Compounds in Supercritical Carbon Dioxide" https://lnkd.in/ggPTYuQZ
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The X-Pulse Broadband Benchtop NMR Spectrometer can easily differentiate between paracetamol and its regioisomers, thanks to its ability to readily detect regioisomerisation, which frequently occurs in pharmaceutical compounds. Want to find out more? Download the application note: https://okt.to/A7bDKm #NMR #NMRSpectroscopy #Pharma #PharmaIndustry #Spectroscopy
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Taming 3-Oxetanyllithium using continuous flow technology in late-stage pharmaceutical analogue synthesis As a useful bioisostere for dimethyl and carbonyl groups for the improvement of physiochemical properties of drug candidates, oxetane ring continues to make its presence felt. https://lnkd.in/gHgmMyv7
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Harnessing strain-release driven reactivity of a chiral SuFEx reagent: Stereocontrolled access to sulfinamides, sulfonimidamides, and sulfoximines. The amine exchange can be done at either the S(IV) or S(VI) oxidation state, leading to diverse chemical space suitable for pharmaceuticals and organocatalysts. Over 70 examples highlight the broad functional group tolerance with an emphasis on complex pharmaceutical amines. Highly functionalized sulfonimidoyl ureas from a common precursor. https://lnkd.in/gfRKY-cz
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