BBSRC’s Post

New research published in The Journal of Clinical Endocrinology & Metabolism. “Women with higher levels of per- and polyfluoroalkyl substances (PFAS) during pregnancy may experience long-term weight gain and heart problems later in life, according to new research published in The Journal of Clinical Endocrinology & Metabolism. PFAS are manmade chemicals found in food packaging, cookware, clothes, drinking water, personal care products and many other consumer goods. These endocrine-disrupting chemicals (EDCs) can interfere with hormones and cause health issues such as obesity, infertility and cancer. “Our study supports the idea that pregnancy may be a sensitive period of PFAS exposure as it may be associated with long-term weight gain and subsequent adverse cardiometabolic health outcomes in women,” said the study’s first author Jordan Burdeau, Ph.D., of the Harvard T.H. Chan School of Public Health in Boston, Mass. “Our findings may improve understanding of the effects of PFAS on cardiometabolic health during pregnancy, which in turn may improve early prevention or detection of adverse cardiometabolic health outcomes in women.” The researchers studied 547 pregnant women in their early 30s, comparing their PFAS levels during pregnancy with cardiometabolic health outcomes at age 50. They found women with higher levels of PFAS in their blood during early pregnancy weighed more and had more body fat at 50 years old than those with lower levels, potentially making them more susceptible to obesity and heart health problems later in life. “It’s important to try to limit your PFAS exposure as it could reduce your risk of health issues later in life,” Burdeau said.” #pfas #edcs #endocrinology #metabolism #endocrinedisruptingchemicals #obesity #heartdisease #cvd #pregnancy #publichealth #publichealthmatters #publichealthpolicy

The German Society for Endocrinology and the German Diabetes Association issued a joint statement on the dangers of endocrine disruptors on fetal brain development, a situation made worse in mothers with iodine deficiency. 🧠 We do not iodise salt in the UK, nor have an iodine fortification programme. 🧠In the UK, women of childbearing age have a mean intake of 141 microgrammes of iodine per day. 🧠12% of women of childbearing age in the UK have iodine intakes below the Lower Reference Nutrient Intake. 🧠UK recommendations are for 150 microgrammes per day for adults, 200microgrammes/day in pregnancy. 🧠The UK ranks 7th among the ten most iodine deficient nations in the world. Source: National Diet and Nutrition Survey rolling programme for 2016 to 2017 and 2018 to 2019 for food consumption, nutrient intakes and nutritional status. Further refs in comments. #iodine #foodfortification #pregnancy #cognitivedevelopment #fetal

Sudden Infant Death Syndrome Linked to Unusual Metabolite Levels: Study Researchers have identified 14 biomarkers that, if atypical at birth, may increase an infant’s risk of sudden infant death syndrome, or SIDS—a condition that has long puzzled doctors... 14 Metabolites Identified The 14 biomarkers identified are metabolites, which are chemicals produced during metabolism. The metabolites are detected in newborn screening, which is done before the baby leaves the hospital... These metabolites include: 1. 17-hydroxyprogesterone, a hormone and precursor to cortisol, the stress hormone. 2. Five amino acids, which are needed to make proteins. 3. Eight acylcarnitines, which are key players in cell energy metabolism. “These metabolites may point to metabolic, endocrine, and neurological abnormalities that could make infants more vulnerable to SIDS,” Warsh told The Epoch Times. “The most noteworthy metabolic pattern revealed by our study was the significance of acylcarnitines to identification of the likelihood of SIDS,” the authors wrote. Acylcarnitines are involved in transporting fatty acids for energy metabolism. Atypical levels of acylcarnitines may indicate “systemic dysfunction” of fatty acid metabolism, the authors said. “Abnormalities in energy metabolism might lead to a lack of energy in critical tissues, including the brain and heart, which could contribute to sudden death,” Warsh said. Preventing Sudden Infant Death Syndrome 1. Proper sleep positioning: Infants should be positioned on their backs during sleep... 2. Using firm mattresses: Soft bedding, pillows, or stuffed animals should be avoided as they can impede breathing. 3. Sharing room with parents: Infants should sleep in the same room as their parents for the first six months... 4. Breastfeeding: Research has found that those who are breastfed have reduced chances of developing SIDS... 5. Temperature control: Infants should be dressed in lightweight clothing and the room temperature should be maintained at a comfortable level... 6. Avoiding tobacco smoke: Tobacco smoke during pregnancy and after birth increases SIDS risks. 7. Introduce pacifiers: Providing a pacifier at nap times and bedtime has been linked with lower risk of SIDS. Credit: Marina Zhang Source: https://lnkd.in/gvm-ctWv

#DHA (docosahexaenoic acid) & "Your Child's 🧠 Brain" Your baby's brain is quite remarkable.keeping it stimulated during the first three years of the brain's growth 📈 & development is extremely important and critical to your baby's learning and future. DHA is an omega-3 fatty acid that plays a crucial role in the development of a baby's brain, especially during pregnancy and early childhood. It is a major structural component of the brain, retina, and nervous system, and sufficient levels of DHA are essential for optimal cognitive and visual development. • Benefits of DHA for #Baby's Brain Development:- 1. Cognitive Function : DHA helps in the formation and function of brain cells, supporting memory, learning, and overall cognitive performance. 2. Visual Development: DHA is a key component of the retina, aiding in the development of a baby’s vision. 3. Nervous System Support: It helps in the growth and development of the nervous system, contributing to better coordination and motor skills. • Sources of DHA for Babies: * Pregnant and Nursing Mothers : Women can support their baby's DHA levels by consuming DHA-rich foods such as fatty fish (salmon, sardines, and mackerel), fortified eggs, and DHA supplements. * Infant Formulas : Many infant formulas are fortified with DHA to ensure that formula-fed babies receive adequate amounts. * Breastfeeding : Breast milk contains DHA, especially if the mother includes DHA-rich foods in her diet. Contact us for DHA Powder & Liquid ! #Nutraceuticals #dhapowder #dhaliquid #brain #heart #babybrain #braindevelopment #babyhealth #childbrain #pharmaceuticals #infantsupplments #nutraindustry #omega3fattyacid #babycare #childcare

🔺POLYCYSTIC OVARY SYNDROME🔺 1. Can be a cause of infertility in up to 20% of infertile couples. ◆Mainly considered to be caused by androgen excess or hyperandrogenism. Underlying cause appears to be insulin resistance. Has several potential comorbidities with endocrine and cardiovascular implications (T2D, obesity) Can affect 6%-10% of women making it one of the most prevalent endocrine disorders in young women. Women younger than 50 are at higher cardiovascular disease risk. 🔺🔺Clinical Presentation Clinical signs of hyperandrogenism: Hirsutism, acne, pattern alopecia. Biochemical signs of hyperandrogenism - Elevated free or total serum testosterone • LH/FSH ratio greater than 2 Infrequent, irregular, or no ovulation, leading to irregular menses Infertility despite unprotected and frequent In patients with obesity (50%-80% of cases), prediabetes (impaired glucose tolerance) or T2D may be present. 🔺🔺🔺Nonpharmacologic Therapy ▲ Weight loss (5%-10%) ▲ Mechanical hair removal for hirsutism 🔺🔺Pharmacotherapy Fertility improvement: ■Clomiphene citrate: 🔺Dosing 50 mg/day for 5 days starting on the third or fifth day of the menstrual cycle Increase to 100 mg if ovulation does not occur after first cycle of treatment. ◆Maximal daily dosage: 150-200 mg/day • Gonadotropin (recombinant FSH) or recombinant gonadotropin-releasing hormone therapy with or without clomiphene Many dosing strategies used. ■ Letrozole 2.5-5 mg daily Symptomatic improvement: • Hormonal contraceptives ▲ first-line therapy for menstrual abnormalities, hirsutism, or acne. - Metformin ▲ Effective for metabolic and glycemic abnormalities, if present, but only modestly effective for hirsutism. • Spironolactone ▲ Can help with hirsutism. #pcos #female #hirsutism #pregnancy #metformin #obesity

🔬The Essential Role of Choline in Prenatal and Cognitive Health, explained: Choline is a critical nutrient that plays a vital role in brain development, particularly during pregnancy. Adequate prenatal choline intake is linked to improved cognitive outcomes and the proper development of the fetal brain and nervous system. Recent research Exploring the Growing Science on Its Benefits for Moms and Babies shows promising evidence that supplementing the maternal diet with additional choline improves several pregnancy outcomes: https://lnkd.in/eibezeXc Additionally, choline supports liver function, memory, and overall cognitive health across the lifespan. In case you didn't hear, we were so proud to announce earlier this summer that Endurance Products Company’s choline supplement has been recognized for its quality and efficacy, leading to its inclusion in a new Colorado bill. This legislation ensures that any woman with Medicaid coverage can access our prenatal choline supplement, expanding access to this crucial nutrient during a key stage of development. This development underscores our commitment to supporting maternal and infant health through evidence-based supplementation. #EnduranceProducts #Choline #PrenatalHealth #CognitiveHealth #MedicaidCoverage #ClinicalNutrition #MaternalHealth #PublicHealth #Colorado

𝗜𝗩𝗙 𝗧𝗶𝗺𝗲-𝗹𝗮𝗽𝘀𝗲 𝗜𝗺𝗮𝗴𝗶𝗻𝗴 𝗦𝘆𝘀𝘁𝗲𝗺 𝗠𝗮𝗿𝗸𝗲𝘁 𝟮𝟬𝟮𝟰-𝟮𝟬𝟯𝟮. 𝗚𝗹𝗼𝗯𝗮𝗹 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗥𝗲𝗽𝗼𝗿𝘁 The global IVF Time-lapse Imaging System market, valued at US$ million in 2023, is projected to reach a readjusted size of US$ million by 2032, with a forecasted CAGR of % during the review period, driven by increasing demand in downstream markets. The research report underscores the growth prospects of this market segment, anticipating steady growth in the future. However, to achieve widespread adoption, factors such as product differentiation, cost reduction, and supply chain optimization are critical. Market participants are advised to focus on research and development, establish strategic partnerships, and tailor their offerings to evolving consumer preferences to fully capitalize on the abundant opportunities within the IVF Time-lapse Imaging System market. 𝗧𝗼 𝗞𝗻𝗼𝘄 𝗚𝗹𝗼𝗯𝗮𝗹 𝗦𝗰𝗼𝗽𝗲 𝗮𝗻𝗱 𝗗𝗲𝗺𝗮𝗻𝗱 𝗼𝗳 𝗜𝗩𝗙 𝗧𝗶𝗺𝗲-𝗹𝗮𝗽𝘀𝗲 𝗜𝗺𝗮𝗴𝗶𝗻𝗴 𝗦𝘆𝘀𝘁𝗲𝗺 𝗠𝗮𝗿𝗸𝗲𝘁. 𝗥𝗲𝗾𝘂𝗲𝘀𝘁 𝗳𝗼𝗿 𝗦𝗮𝗺𝗽𝗹𝗲 𝗣𝗗𝗙: https://lnkd.in/gWJYz84y *𝗕𝘆 𝗧𝘆𝗽𝗲: Software, Hardware *𝗕𝘆 𝗔𝗽𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻: Hospital, Fertility Clinic, Others *𝗕𝘆 𝗥𝗲𝗴𝗶𝗼𝗻: North America, Europe, Asia-Pacific, South America, Middle East & Africa *𝗕𝘆 𝗞𝗲𝘆 𝗣𝗹𝗮𝘆𝗲𝗿𝘀: Vitrolife, Esco Medical, Genea Biomedx #ivf #timelapse #imaging #system #fertility #healthcare #technology #medical #science #reproductivehealth #assistedreproduction #infertility #biotechnology #womenhealth #familyplanning #pregnancy #innovation #IVFclinic #medicaldevices #laboratory #embryology #IVFjourney #parenthood #IVFsuccess #healthtech #IVFawareness #IVFtreatment #IVFcommunity #futureofmedicine

𝗜𝗩𝗙 𝗧𝗶𝗺𝗲-𝗹𝗮𝗽𝘀𝗲 𝗜𝗺𝗮𝗴𝗶𝗻𝗴 𝗦𝘆𝘀𝘁𝗲𝗺 𝗠𝗮𝗿𝗸𝗲𝘁 𝟮𝟬𝟮𝟰-𝟮𝟬𝟯𝟮. 𝗚𝗹𝗼𝗯𝗮𝗹 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗥𝗲𝗽𝗼𝗿𝘁 The global IVF Time-lapse Imaging System market, valued at US$ million in 2023, is projected to reach a readjusted size of US$ million by 2032, with a forecasted CAGR of % during the review period, driven by increasing demand in downstream markets. The research report underscores the growth prospects of this market segment, anticipating steady growth in the future. However, to achieve widespread adoption, factors such as product differentiation, cost reduction, and supply chain optimization are critical. Market participants are advised to focus on research and development, establish strategic partnerships, and tailor their offerings to evolving consumer preferences to fully capitalize on the abundant opportunities within the IVF Time-lapse Imaging System market. 𝗧𝗼 𝗞𝗻𝗼𝘄 𝗚𝗹𝗼𝗯𝗮𝗹 𝗦𝗰𝗼𝗽𝗲 𝗮𝗻𝗱 𝗗𝗲𝗺𝗮𝗻𝗱 𝗼𝗳 𝗜𝗩𝗙 𝗧𝗶𝗺𝗲-𝗹𝗮𝗽𝘀𝗲 𝗜𝗺𝗮𝗴𝗶𝗻𝗴 𝗦𝘆𝘀𝘁𝗲𝗺 𝗠𝗮𝗿𝗸𝗲𝘁. 𝗥𝗲𝗾𝘂𝗲𝘀𝘁 𝗳𝗼𝗿 𝗦𝗮𝗺𝗽𝗹𝗲 𝗣𝗗𝗙: https://lnkd.in/gWJYz84y *𝗕𝘆 𝗧𝘆𝗽𝗲: Software, Hardware *𝗕𝘆 𝗔𝗽𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻: Hospital, Fertility Clinic, Others *𝗕𝘆 𝗥𝗲𝗴𝗶𝗼𝗻: North America, Europe, Asia-Pacific, South America, Middle East & Africa *𝗕𝘆 𝗞𝗲𝘆 𝗣𝗹𝗮𝘆𝗲𝗿𝘀: Vitrolife, Esco Medical, Genea Biomedx #ivf #timelapse #imaging #system #fertility #healthcare #technology #medical #science #reproductivehealth #assistedreproduction #infertility #biotechnology #womenhealth #familyplanning #pregnancy #innovation #IVFclinic #medicaldevices #laboratory #embryology #IVFjourney #parenthood #IVFsuccess #healthtech #IVFawareness #IVFtreatment #IVFcommunity #futureofmedicine

𝗜𝗩𝗙 𝗧𝗶𝗺𝗲-𝗹𝗮𝗽𝘀𝗲 𝗜𝗺𝗮𝗴𝗶𝗻𝗴 𝗦𝘆𝘀𝘁𝗲𝗺 𝗠𝗮𝗿𝗸𝗲𝘁 𝟮𝟬𝟮𝟰-𝟮𝟬𝟯𝟮. 𝗚𝗹𝗼𝗯𝗮𝗹 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗥𝗲𝗽𝗼𝗿𝘁 The global IVF Time-lapse Imaging System market, valued at US$ million in 2023, is projected to reach a readjusted size of US$ million by 2032, with a forecasted CAGR of % during the review period, driven by increasing demand in downstream markets. The research report underscores the growth prospects of this market segment, anticipating steady growth in the future. However, to achieve widespread adoption, factors such as product differentiation, cost reduction, and supply chain optimization are critical. Market participants are advised to focus on research and development, establish strategic partnerships, and tailor their offerings to evolving consumer preferences to fully capitalize on the abundant opportunities within the IVF Time-lapse Imaging System market. 𝗧𝗼 𝗞𝗻𝗼𝘄 𝗚𝗹𝗼𝗯𝗮𝗹 𝗦𝗰𝗼𝗽𝗲 𝗮𝗻𝗱 𝗗𝗲𝗺𝗮𝗻𝗱 𝗼𝗳 𝗜𝗩𝗙 𝗧𝗶𝗺𝗲-𝗹𝗮𝗽𝘀𝗲 𝗜𝗺𝗮𝗴𝗶𝗻𝗴 𝗦𝘆𝘀𝘁𝗲𝗺 𝗠𝗮𝗿𝗸𝗲𝘁. 𝗥𝗲𝗾𝘂𝗲𝘀𝘁 𝗳𝗼𝗿 𝗦𝗮𝗺𝗽𝗹𝗲 𝗣𝗗𝗙: https://lnkd.in/gWJYz84y *𝗕𝘆 𝗧𝘆𝗽𝗲: Software, Hardware *𝗕𝘆 𝗔𝗽𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻: Hospital, Fertility Clinic, Others *𝗕𝘆 𝗥𝗲𝗴𝗶𝗼𝗻: North America, Europe, Asia-Pacific, South America, Middle East & Africa *𝗕𝘆 𝗞𝗲𝘆 𝗣𝗹𝗮𝘆𝗲𝗿𝘀: Vitrolife, Esco Medical, Genea Biomedx #ivf #timelapse #imaging #system #fertility #healthcare #technology #medical #science #reproductivehealth #assistedreproduction #infertility #biotechnology #womenhealth #familyplanning #pregnancy #innovation #IVFclinic #medicaldevices #laboratory #embryology #IVFjourney #parenthood #IVFsuccess #healthtech #IVFawareness #IVFtreatment #IVFcommunity #futureofmedicine

📍 What are 'Ozempic babies?' Can the drug really increase your chance of pregnancy? Ozempic and related drugs (glucagon-like peptide-1 receptor agonists or GLP-1-RAs) were developed to help control blood glucose levels in people with type 2 diabetes. Now we're seeing a rise in stories about "Ozempic babies," where women who use drugs like Ozempic (semaglutide) report unexpected pregnancies. Obesity affects the fine-tuned hormonal balance that regulates the menstrual cycle. Women with a body mass index (BMI) above 27 are three times more likely than women in the normal weight range to be unable to conceive because they are less likely to ovulate. The metabolic conditions of type 2 diabetes and polycystic ovary syndrome (PCOS) are both linked to obesity and fertility difficulties. Women with type 2 diabetes are more likely than other women to have obesity and to experience fertility difficulties and miscarriage. Similarly, women with PCOS are more likely to have obesity and trouble conceiving than other women because of hormonal imbalances that cause irregular menstrual cycles. In men, obesity, diabetes and metabolic syndrome (a cluster of conditions that increase the risk of heart disease and stroke) have negative effects on fertility. Low testosterone levels caused by obesity or type 2 diabetes can affect the quality of sperm. As weight loss can improve menstrual irregularities, it may also increase the chance of pregnancy in women with obesity. This is why weight loss and metabolic improvement are the most likely reasons why women who use Ozempic report unexpected pregnancies. But unexpected pregnancies have also been reported by women who use Ozempic and the contraceptive pill. This has led some experts to suggest that some GLP-1-RAs might affect the absorption of the pill and make it less effective. In men with type 2 diabetes, obesity and low testosterone, drugs like Ozempic have shown promising results for weight loss and increasing testosterone levels. Dara from animal studies suggest it should not be used in pregnancy due to potential risks of fetal abnormalities. That's why the Therapeutic Goods Administration recommends women of childbearing potential use contraception when taking semaglutide. Read ➡️ https://lnkd.in/eWAsubtc #fertility #pregnancy