BEYOND PESTICIDES’ Post

A team of researchers investigated the genetic patterns of helicobacter pylori, a bacterium responsible for chronic gastritis, a condition characterized by inflammation of the stomach lining, along with 90 other closely related species collectively known as Campylobacteria. ---------- For the latest in #healthcare, #medtech, #medicaldevices, #diagnostics and #medical world, follow MedTechAsia.in  ---------- #drugresistance #bacteria #gastritis #chronicgastritis #bacteria #researchers #research #medicalstudies

New research published in The Journal of Toxiological Sciences #neonicotinoids #insecticides #neurotoxic #neurotoxicity #developmentaltoxicity #environment #environmental #environmentalpolicy #sustainableagriculture #organicagriculture #organicfarming

Milk to the rescue for diabetics: Cow produces human insulin in milk A brown bovine has made history as the first transgenic cow capable of producing human insulin in her milk. The advancement, led by researchers from the University of Illinois Urbana-Champaign and the Universidade de São Paulo, could herald a new era in insulin production, one day eliminating drug scarcity and high costs for people living with diabetes. Scientists inserted a segment of human DNA coding for proinsulin -- the protein precursor of the active form of insulin -- into cell nuclei of 10 cow embryos. These were implanted in the uteruses of normal cows, and one transgenic calf was born. Authors say even a small herd could quickly outcompete existing methods -- transgenic yeast and bacteria -- for producing insulin, and could do so without having to create highly technical facilities or infrastructure. An efficient system to collect and purify insulin products would be needed, as well as FDA approval, before transgenic cows could supply insulin for the world's diabetics.

Exciting advancements in insulin production are on the horizon! Currently, insulin is produced by inserting human genes into bacteria, a costly process. A novel approach using cows has been proposed, where human DNA related to insulin production is integrated into cow embryos. This leads to calves that can produce insulin in their milk, potentially making insulin more affordable and accessible globally. If approved, just 100 Holstein cows might suffice to meet the entire U.S. insulin demand. This could significantly impact insulin availability, especially in lower-income regions. https://lnkd.in/eqmDu6mN

🌐 Exciting New Research Alert!🚀 I am delighted to share our latest publication📑which delves into the intricate world of environmental pollutants - exploring how heavy metals and pesticides may significantly impact male reproductive health. The study highlights oxidative stress and endocrine disruption as key players in altering sperm parameters and reproductive hormones. 🧐Importance- With rising technological advancements, understanding the threats posed by environmental pollutants becomes crucial for safeguarding reproductive well-being. Rohit Gautam Dr Eepsita Priyadarshini 📰 **Read the full article below and let's continue advancing our knowledge for a healthier future! 🌱✨ #Research #EnvironmentalScience #MaleReproductiveHealth #Toxicology #Carcinogenesis #ScientificAdvancements 🌐🔬

Daily News: Meta-Analysis Catalogues Pesticides’ Adverse Impact on How Genes Function A team from the Molecular Oncology Research Center at Barretos Cancer Hospital in Brazil (Hospital de Amor) finds epigenetic changes, including changes relating to “DNA methylation, histone modification, and differential microRNA expression [which ‘can alter the expression of many disease-related genes’],” in a review and meta-analysis of existing literature in the PubMed, Embase, and Cochrane databases. Out of 3,529 articles initially found, 28 articles were selected for eligibility. Studies were not included if the participants were not considered “healthy individuals” or if the participants had “known inherent/congenital or acquired genetic disorder[s].” One study involved tracking micro-RNA (miRNA) profiles from the urine of farmworkers exposed to organophosphate pesticides. “A cohort of mother-child farmworker pairs exposed to organophosphate pesticides and non-farmworker pairs was studied by measuring urinary microRNA profiles []. Significant differences in miRNA profiles were found between adult farmworkers and non-farmworkers and also between seasons. During the post-harvest season, six miRNAs were identified as being positively associated with farmworkers.” BEYOND PESTICIDES has discussed extensively the impact of pesticide exposure on human health, particularly in its relationship with epigenetics and environmental obesogens. Environmental obesogens are chemicals proven to have a health impact on metabolic systems relating to obesity. For a broader history of independent and peer-reviewed scientific literature in this field of study, please see the Daily News Blog section on epigenetics: https://ow.ly/VWce50RsH96 Daily News Blog Post: https://ow.ly/o8vl50RsH9Y

https://lnkd.in/dVKQDkjy Genes, Volume 15, Issue 2 (February 2024) Human Genomics and Genetic Diseases Review: Genetic Basis of Pigment Dispersion Syndrome and Pigmentary Glaucoma: An Update and Functional Insights Shisong Rong, Xinting Yu and Janey L. Wiggs Genes 2024, 15(2), 142; DOI: 10.3390/genes15020142 Review: Genomic Features of Homologous Recombination Deficiency in Breast Cancer: Impact on Testing and Immunotherapy Umer Ali, Sunitha Vungarala and Venkataswarup Tiriveedhi Genes 2024, 15(2), 162; DOI: 10.3390/genes15020162 Review: The Intriguing Mystery of RPA Phosphorylation in DNA Double-Strand Break Repair Valerie J. Fousek-Schuller and Gloria E. O. Borgstahl Genes 2024, 15(2), 167; DOI: 10.3390/genes15020167 Review: Cardiac and Nephrological Complications Related to the Use of Antiangiogenic and Anti-Programmed Cell Death Protein 1 Receptor/Programmed Cell Death Protein 1 Ligand Therapy Paulina Stachyra-Strawa, Lidia Szatkowska-Sieczek, Paweł Cisek, Paweł Gołębiowski and Ludmiła Grzybowska-Szatkowska Genes 2024, 15(2), 177; DOI: 10.3390/genes15020177 Article: Validation of Endogenous Control Genes by Real-Time Quantitative Reverse Transcriptase Polymerase Chain Reaction for Acute Leukemia Gene Expression Studies Flávia Melo Cunha de Pinho Pessoa, Vitória Beatriz de Jesus Viana, Marcelo Braga de Oliveira, Beatriz Maria Dias Nogueira, Rodrigo Monteiro Ribeiro, Deivide de Sousa Oliveira, Germison Silva Lopes, Ricardo Parente Garcia Vieira, Manoel Odorico de Moraes Filho, Maria Elisabete Amaral de Moraes, André Salim Khayat, Fabiano Cordeiro Moreira and Caroline Aquino Moreira-Nunes Genes 2024, 15(2), 151; DOI: 10.3390/genes15020151 Article: Cognitive Function Is Associated with the Genetically Determined Efficiency of DNA Repair Mechanisms Nicolas Cherbuin, Hardip Patel, Erin I. Walsh, Ananthan Ambikairajah, Richard Burns, Anne Brüstle and Lene Juel Rasmussen Genes 2024, 15(2), 153; DOI: 10.3390/genes15020153 ................. Molecular Genetics and Genomics Review: Landscape of Constitutional SOX4 Variation in Human Disorders Mina Grippa and Claudio Graziano Genes 2024, 15(2), 158; DOI: 10.3390/genes15020158

It is known that the interaction between gene-environmental (#GxE) 🧬-🌍 can lead to #complexdiseases 🤒. However, due to the limitation of finding highly exposed populations for a specific compound 😞, the studies focused on associated environmental risk factors are often limited to diet, alcohol usage, and smoking. Therefore, new approach methodologies (#NAMs) are necessary to elucidate chemicals’ potential for differential population response 💪. In addition, not all populations can respond to the same chemical exposure, so it is necessary to define different exposure thresholds depending on the population 💡. Today I want to present the disease quotient genetic overview score (#DisQGOS) (https://lnkd.in/eknKp5ky), designed to quantify #chemical risk for specific diseases and predict GxE interaction potential 😲. This method is split by 1) #DisQ, which estimates the overall potential for a chemical-disease 💊 association using a #hazard quotient ⚗ and the association between a chemical-disease enrichment, and 2) #GOS, the genetic 🧬overview score and helps to find the potential for these chemical-disease associations to lead to the differential population response 🤯. To compute GOS, we need genetic variants extracted from our source #DisGeNET (now called #DISGENETplus 😁) and the minor allele frequency (#MAF) 🌎 from the #1000Genomes project. DisQGOS can use chemical-variant-disease information to compute the risk value of chemical exposure to develop a disease 👨🔬. This risk value can be different across populations (#ethnic groups). Methods like DisQGOS can help to establish different 📣 population susceptibility scores to chemical exposures 💅(such as #cosmeticsindustry, #washing products, or #adhesives) and increase understanding of the interplay between chemical exposures and genetics in disease progression to enhance chemical risk assessment 👏 . 

Discover Diverse PhD Opportunities at the University of Nottingham BBSRC DTP 1. mRNA Cap Methylation and Gene Expression: Dive into a groundbreaking project in collaboration with AstraZeneca focusing on mRNA modifications and RNA therapeutics. Apply before Jan 16, 2024. https://lnkd.in/d8J5zYAW 2. Role of Extracellular Matrix in Hypoxic Metastasis: Explore the dynamic world of glycosaminoglycans and their impact on cancer metastasis in a multidisciplinary research environment. Apply by Jan 16, 2024. https://lnkd.in/ddRDSznt 3. Insects' Microbiome and Chicken Nutrition: Investigate the potential of insect microbiomes as a sustainable protein source in poultry nutrition. Apply before Jan 16, 2024. https://lnkd.in/dEDz-wZV 4. Optimisation of Protease Feed Additives in Poultry: Contribute to enhancing protein utilization efficiency in poultry through innovative feed additives in collaboration with industry partner KEMIN. Apply by Jan 16, 2024. https://lnkd.in/dQ_g7vfc #PhDResearch #Biotechnology #CancerResearch #SustainableAgriculture #NutritionScience #RNAtherapeutics #MicrobiomeStudy #ProteinUtilization #BiomedicalInnovation #UniversityOfNottingham #BBSRCDTP #AcademicExcellence

Milk to the rescue for diabetics? 🐄🌱 Exciting news for the diabetes community! Researchers in Illinois have made a groundbreaking discovery by creating the world's first insulin-producing cows. This innovative project could potentially revolutionize diabetes treatment and management. Imagine the possibility of using milk as a source of insulin for diabetics. This development not only showcases the power of biotechnology but also highlights the potential for sustainable and accessible healthcare solutions. As we continue to witness the intersection of science, agriculture, and healthcare, it's inspiring to see how innovation can truly make a difference in people's lives. What are your thoughts on this remarkable advancement? Share your insights below! #DiabetesResearch #Biotechnology #HealthcareInnovation https://lnkd.in/dKR5M24i Milk to the rescue for diabetics?  Illinois project creates first insulin-producing cows. In a groundbreaking feat, researchers from #ILLINOIS and Brazil have successfully engineered the first insulin-producing cow, a potential game-changer for diabetes treatment. "Mother Nature designed the mammary gland as a factory to make protein really, really efficiently. We can take advantage of that system to produce a protein that can help hundreds of millions of people worldwide." — Matt Wheeler, Lead Researcher https://lnkd.in/dKR5M24i Monzani, P. S., Sangalli, J. R., Sampaio, R. V., Guemra, S., Zanin, R., Adona, P. R., Berlingieri, M. A., C. Cunha-Filho, L. F., Mora- Ocampo, I. Y., Pirovani, C. P., Meirelles, F. V., Wheeler, M. B., & Ohashi, O. M. (2024). Human proinsulin production in the milk of transgenic cattle. Biotechnology Journal, 19(3), 2300307. https://lnkd.in/dR76bDC3