bioAffinity Technologies’ Post

This course discusses oral cancer and chemoprevention, focusing on the benefits of green tea and curcumin as chemopreventive agents. Lessons include an overview of oral cancer, the importance of chemoprevention, and the use of hamster buccal pouch carcinoma model. It delves into the study aims and methodology, analyzing a case study of oral cancer progression. The course further explores the results of various studies on chemoprevention, clinical and histological findings, the effect on cell proliferation, angiogenesis, apoptosis, and the advantages of combination treatments. The course also investigates the mechanisms of action underlying the chemopreventive effects of green tea and curcumin, their impact on cell cycle regulation, apoptosis, and cell signaling pathways. Finally, discussions include continuous vs combination treatment, timing of chemoprevention, limitations of curcumin monotherapy, and future research directions. #OralCancer #Chemoprevention #GreenTeaCurcumin

Last week on #PCaFact Friday, we addressed the asymptomatic nature of prostate cancer. As a result, it is vital to stay up-to-date with the current health guidelines surrounding prostate cancer screening. Currently, the CDC recommends to consider the following before screening: - If you have a family history of prostate cancer - If you are African American - If you have other medical conditions that may make it difficult for you to be treated for prostate cancer if it is found, or that may make you less likely to benefit from screening - How you value the potential benefits and harms of screening, diagnosis, and treatment Talk to your doctor to learn more about your options for prostate cancer screening. Source: https://ow.ly/BrK950PJ94C #Promaxo #ProstateCancerAwarenessMonth #ProstateCancer

Second most common cancer in men worldwide? [Read more below] Prostate cancer is the second most common cancer in men worldwide, with an estimated 1 in 8 men being diagnosed during their lifetime. Prostate cancer, a disease where cancerous cells form in the tissues of the prostate gland, affects a staggering number of men across the globe. While age is a significant risk factor, it's essential to note that younger men can also be diagnosed. Early detection is crucial, as prostate cancer often shows no symptoms in its early stages. Regular screenings, such as the prostate-specific antigen (PSA) blood test and digital rectal exams, are vital in catching the disease early when it is most treatable. #ProstateHealthMonth #CancerAwareness #KnowYourRisk

Pan-cancer analysis of post-translational modifications An analytical resource of posttranslational modifications (PTMs) from over 1,000 patients across 11 cancer types reveals pan-cancer changes involved in hallmark cancer processes and reveals potential new therapeutic avenues. The authors found 33 pan-cancer multi-omic signatures and PTM dysregulation is associated with distinct DNA damage repair mechanisms. They also found that changes in acetylation of metabolic proteins correlate with tumor immune state and phosphorylation of Thr/Ser kinases is affected by proximal acetylation. #sciencenewshighlights #ScienceMission https://lnkd.in/g9A95Qdh

4-1BB, also known as CD137 or TNFRSF9, is a protein receptor primarily found on the surface of activated T cells, natural killer (NK) cells, dendritic cells, and other immune cells. It belongs to the tumor necrosis factor receptor superfamily (TNFRSF). Due to its potent immunostimulatory effects, 4-1BB has attracted significant interest as a target for immunotherapy in cancer treatment. Check out our B-h4-1BB mice(https://lnkd.in/dN___c3), B-hPD-1/h4-1BB mice(https://lnkd.in/d5aAhdCW) and B-hPD-L1/h4-1BB mice(https://lnkd.in/duECZj2Q). #TumorResearch #immunecheckpoint #preclinicalresearch #immunotherapy #cancerresearch #cancertherapy #PreclinicalStudies #HumanizedModels #CancerAwareness 

Today, the spotlight is shifting towards a relatively hidden player in cancer research: the tumor microenvironment (TME). Think of the TME as the dynamic neighborhood surrounding a tumor, featuring local and infiltrating host cells, secreted molecules, blood vessels, and the extracellular matrix (ECM). This bustling environment actively influences tumor progression and boasts unique characteristics compared to healthy tissues. Notably, the TME also impacts the response to anticancer treatments, altering the course of cancer therapy. In the quest to enhance cancer treatment, an exciting trend is emerging – the development of drug carriers that specifically target the TME. 🎯🔬 A comprehensive review of these innovations by Prof. Yahya Choonara is now available: https://tiny.pl/c4q7n The big question: Does this signify the end of traditional 2D cancer cell cultures in research? 🧪🤔 #TumorMicroenvironment #CancerResearch #InnovationsInTreatment #ACCORDConference

Understanding the role of #HPV in cervical cancer is crucial for developing targeted therapies. This study by Caroline Carvalho investigated how different HPV types influence mutational signatures by analyzing APOBEC enzyme activity. Preliminary results show that APOBEC mutation rates are similar across HPV16 and HPV18 groups, but further analysis with clinical data is needed. Expanding the study to include INCA patients will provide more insights into how various HPV types influence mutational profiles and the role of APOBEC enzymes in cancer development. #2MinutePosterPitch #CancerResearch #HPV #Genomics #VEME2024 https://lnkd.in/dU-ET3AQ

🔬 Cancer's Biggest Roadblock Finally Toppled? New Peptide Libraries Offer Hope Against the Elusive MYC Protein! For decades, the MYC oncogene has been a major obstacle in cancer treatment, responsible for over 70% of human cancers. But groundbreaking research has unveiled a revolutionary approach that could change the game forever! In this must-read blog post, discover how scientists have developed next-gen peptide libraries that can successfully target and inhibit MYC - a feat once thought impossible. Uncover 5 key insights into this pioneering study, straight from the Journal of the American Chemical Society, that could pave the way for more effective cancer therapies. Don't miss out on this game-changing development! Read the full blog post and stay ahead of the curve. 👇 https://bit.ly/4atlOeY #CancerResearch #MYCProtein #PeptideLibraries #BreakthroughScience #HopeForCancer #Sanux

🔬 Cancer's Biggest Roadblock Finally Toppled? New Peptide Libraries Offer Hope Against the Elusive MYC Protein! For decades, the MYC oncogene has been a major obstacle in cancer treatment, responsible for over 70% of human cancers. But groundbreaking research has unveiled a revolutionary approach that could change the game forever! In this must-read blog post, discover how scientists have developed next-gen peptide libraries that can successfully target and inhibit MYC - a feat once thought impossible. Uncover 5 key insights into this pioneering study, straight from the Journal of the American Chemical Society, that could pave the way for more effective cancer therapies. Don't miss out on this game-changing development! Read the full blog post and stay ahead of the curve. 👇 https://bit.ly/4atlOeY #CancerResearch #MYCProtein #PeptideLibraries #BreakthroughScience #HopeForCancer #Sanux

One blood test. Over 50 types of cancer identified in a clinical study through a shared cancer signal.¹ Adding the Galleri test to recommended screening tests redefines what’s possible in cancer screening. See Important Safety Information at https://bit.ly/45FRUlI #MCED #MultiCancerEarlyDetection #CancerScreening #DetectCancerEarly The Galleri test should be used in addition to healthcare provider recommended screening tests. The Galleri test does not detect a signal for all cancers and not all cancers can be detected in the blood. False positive and false negative results do occur. References: 1. Klein EA, et al. Ann Oncol. 2021;32(9):1167-1177. doi: 10.1016/j.annonc.2021.05.806.