Bioanalysis Zone’s Post

Matrix interference in anti-drug antibody (ADA) assays can present challenges in assay development and data analysis, particularly in clinical study samples. One strategy for reducing matrix interference is the utilization of a nanoliter-scale, flow-through microfluidic immunoassay platform. This webinar will present a case study highlighting the advantages of using the Gyrolab® platform in clinical ADA method development to minimize matrix interference. The case study will also compare this platform to other assay formats and platforms that are commonly used in clinical ADA method development.

Automation and miniaturisation has started to change the landscape of labs already so 10 years time?

Ensure the quality of your proteins during your downstream processes when using Shenandoah CTGrade recombinant proteins from FUJIFILM Irvine Scientific. Check out our recent tech note to learn the significance of endotoxin levels downstream, the details of current testing guidelines, and how our CTGrade proteins compare to competitors. https://brnw.ch/21wHrB4

Do you know why the Optilite® analyser is the preferred analyser for special protein testing for over 1000 laboratories worldwide? Since launch, over 1500 Optilite analyser instruments have displaced other protein analysers because of the high quality results and workflow benefits it brings to laboratories worldwide, including key myeloma reference centres. Find out more about the dedicated analyser from the Binding Site at Worldlab 2024! #WorldLab #WorldLab2024

Are you facing challenges in extracting membrane proteins for your research? We offer a revolutionary solution with their solubilizing reagent kit, designed to stabilize the protein without any structure modifications💡 Our kit significantly enhances the solubilization and stability of membrane proteins, ensuring more reliable and consistent research results. It comes with pre-packaged reagents in small quantities, allowing you to efficiently identify the optimal detergent for their specific membrane protein and simplify the testing and optimization of extraction protocols. ✨Key features of the CALIXAR solubilizing reagent kit include: • Improved stability of membrane proteins in solution • Enhanced crystallogenesis of membrane proteins • Promote crystallization for functionally active membrane proteins • Versatility for use with both membrane and soluble proteins Leveraging cutting-edge research and expertise, our kits promise to upgrade your membrane protein extraction process, leading to more accurate and reliable results. 👉 Get your kit today and embark on a journey towards groundbreaking insights in the realm of protein science! Find more details at: https://lnkd.in/gYsvAfWk #EurofinsDiscoverX #EurofinsDiscovery #ProteinResearch #DrugDiscovery #ProteinExtraction

Challenges with Host Cell Protein Analysis? In this recent paper from scientists at Merck, they utilize the Evosep One coupled to a Bruker timsTOF Pro 2 to overcome the challenges of host cell protein (HCP) analysis. By leveraging diaPASEF, they were able to reveal the presence of more than 600 additional HCPs previously missed by DDA PASEF. In addition to improved characterization of the sample, they were able to increase throughput and eliminate carryover! Taku Tsukidate, Alyssa Stiving, Shannon Rivera, Ansuman Sahoo, Sri Madabhushi, Xuanwen Shawn Li Take a look at the full manuscript 👇 👇👇 https://lnkd.in/e4QkQSyy To learn more about the Evosep One, visit our website evosep.com or reach out to me for additional information. #Evosep, #Bruker, #Hostcellproteins, #hcp,

Precise #mRNApurity assessment for accelerated therapeutic development and #releasetesting The quantification of #mRNA in solutions presents an array of challenges, including a lack of accuracy when determining purity ratio with traditional technologies, and the introduction of potential errors and risks through sample preparation or dilution. Next month, Repligen Corporation’s Paul Mania (Bioanalytics Applications Specialist) will introduce a precise #mRNApurity assessment technique that provides results that closely match theoretical purity ratios while avoiding risks associated with sample dilution, enhancing the efficiency of #mRNAproduction. Register for this #webinar below:

WuXi Biologics utilizes high-throughput (HTP) CHO cells to deliver high-yielding mini proteins with exceptionally low endotoxin levels. This method surpasses traditional E. coli production, offering significant advantages: Exceptional yields: Achieve yields ranging from 100 to 500 mg/L through high-titer transient CHO expression. Rapid turnaround: Benefit from HTP production coupled with fast binding constant (Kd) measurements. Streamlined workflow: Enjoy a swift process from gene sequence to binding assays, with delivery within 4-5 weeks.

In today's complex bioprocessing landscape, optimizing downstream purification is crucial for developing next-generation biotherapeutics. The challenges of enhancing productivity while reducing costs are more pressing than ever. Join Andy and Mark for an insightful webinar: "Addressing the Challenges of Complex Biologic Purification: New Advances in Protein A Affinity Resins" In this session, we'll explore: 1. The evolving landscape of protein A chromatography resins 2. How strategic partnerships are driving technology innovation in bioprocessing 3. Discover how our new DurA Cycle™ A50 can increase productivity and reduce costs through improved stability and low ligand leakage. 4. Performance data from Ecolab's wider protein A toolbox resins  Register here: https://lnkd.in/g8pFNX7Q DurA Cycle™ A50 is the most recent addition to our well-received protein A resins. Attend and learn how Ecolab can assist with your challenges in implementing and optimizing a mAb purification process.

Revolutionize Your Protein Extraction Workflow! Say goodbye to complicated, time-consuming protein extraction methods! The Covaris truPREP Protein 12x8 Strip Kit for Mammalian Cells is here to streamline your protein sample preparation process. With our innovative adaptive focused acoustics® (AFA®) technology, you can achieve fast & reliable protein extraction from cell pellets in a simple, single-consumable workflow. The kit is designed for flexibility & scalability, accommodating a wide range of initial cell counts & ensuring reproducibility & efficiency. 🔹 Efficiency: Reduce sample prep time & costs while maintaining high data quality. 🔹 Flexibility: Compatible with various mammalian cell lines for diverse research needs. 🔹 Scalability: Process 8–96 samples with the same workflow for greater throughput. Learn more about how the truPREP Protein Kit can enhance your research: https://bit.ly/3BczbnA #ProteinResearch #LifeSciences #Proteomics