A Review published in Molecular Medicine discusses the pathogenic mechanisms of cardiovascular damage in COVID-19 patients and provides some useful suggestions for future clinical diagnosis, treatment and prevention.
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When added to guideline-directed therapies for heart failure with reduced ejection fraction (HFrEF), a traditional Chinese medicine called qiliqiangxin reduced the composite endpoint of cardiovascular death and heart failure hospitalization by more than 20%, results of a large placebo-controlled trial show. "The risk reductions in both cardiovascular death and heart failure hospitalization were substantial, clinically important, and consistent across all subgroups," reported Xinli Li, MD, PhD, First Affiliated Hospital, Nanjing Medical University, China. Qiliqiangxin, a commonly used therapy in China for cardiovascular disease, is not a single chemical entity but a treatment composed of 11 plant-based substances that together are associated with diuretic effects, vasodilation, and "cardiotonic" activity,
Traditional Chinese Medicine Improves Outcomes in HFrEF
medscape.com
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LHI Lecture May 8, noon: “Precision Medicine: New Directions in Atherosclerotic Cardiovascular Disease Prevention” Christie M. Ballantyne, M.D. Professor of Medicine and Chief Sections of Cardiology and Cardiovascular Research Baylor College of Medcine More about Dr. Ballantyne from the Baylor website: https://buff.ly/3UmkJAv Location: 1-101 Microbiology Research Facility (MRF) 689 23rd Ave SE, Minneapolis, MN Map: https://buff.ly/3VJm19Z Webcast @ buff.ly/4cIssQI Learning Objectives 1. Describe current approach and role of risk assessment to guide intensity of lifestyle interventions and pharmacotherapy in cardiovascular prevention 2. Summarize genetic testing available and current role in cardiovascular disease prevention 3. Discuss the conceptual framework for addressing residual cardiovascular disease risk with a focus on triglycerides and inflammation 4. Describe the association of clonal hematopoiesis of indeterminate potential (CHIP) to development of cardiovascular disease and the potential role of a high risk CHIP score algorithm
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Founder, President of R&D, CSO and CBO of PharmAbcine, Inc. CEO and President of Wincal BioPharm, CEO and President of PharmAbcine Australia
#PMC403 #TIE2ActivatingAntibody #Sepsis #SystemicInflammation is a hallmark of commonly encountered diseases ranging from #bacterial sepsis to sterile syndromes such as major #trauma. Derangements in the host vasculature contribute to the cardinal manifestations of sepsis in profound ways. Recent studies of control pathways regulating the vascular endothelium have illuminated how this single cell layer toggles between quiescence and activation to affect the development of shock and multiorgan dysfunction. This article focuses on one such control pathway, the #Tie2 receptor and its ligands the angiopoietins, to describe a growing body of genetic, biochemical, mechanistic, and human studies that implicate Tie2 as a critical switch. In health, activated Tie2 maintains the endothelium in a quiescent state characterized by dynamic barrier function and antiadhesion against circulating leukocytes. In sepsis and related diseases, expression of the angiopoietins becomes markedly imbalanced and Tie2 signaling is greatly attenuated. These rapid molecular changes potentiate pathophysiologic responses throughout the body, resulting in injurious vascular leakage and organ inflammation. The Tie2 axis, therefore, may be a promising avenue for future translational studies.
The Angiopoietin-Tie2 Signaling Axis in Systemic... : Journal of the American Society of Nephrology
journals.lww.com
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Researchers at Indiana University School of Medicine have identified a crucial protein marker that helps pinpoint cells capable of repairing damaged blood vessels. This breakthrough, published in the prestigious journal Circulation, opens the door to developing innovative therapies for endothelial dysfunction, a major contributor to coronary artery disease and related cardiovascular conditions. #medicalresearch #researchanddevelopment #research #innovation #cardivascular #heartdisease #lifesciences #indiana
Biomarker found to help identify cells that can repair damaged blood vessels
medicine.iu.edu
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A new Grand Round on endothelial senescence in IPF and COPD is available on RB&HH education website. Dr Koralia Paschalaki, respiratory physician and senior clinical research fellow at the National Heart and Lung Institute, was invited to present her research on the molecular mechanisms of endothelial dysfunction and vascular disease in patients with chronic lung disorders, including COPD and IPF. Using circulating endothelial progenitors, she has provided the first evidence of accelerated endothelial ageing (senescence) due to epigenetic dysfunction in patients with COPD, providing novel insights into the development of cardiovascular disease in this group. Watch it here - https://bit.ly/4cuT0nS
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Commissioning Editor, Reviews in Cardiovascular Medicine (ISSN: 1530-6550, SCIE, IF: 1.9), IMR Press
[Join the discussion] 🛰 We are thrilled to announce a Call for Papers on the theme of “#SuddenCardiacDeath (SCD)” in Reviews in Cardiovascular Medicine. About RCM: https://lnkd.in/gZhDbnDY Instructions for Authors: https://lnkd.in/gkMaq9up For details: twinkle.xu@imrpress.com Sub-topics but not limited to: (1) Genetic predispositions and hereditary syndromes associated with SCD (2) Novel diagnostic techniques and biomarkers for early detection (3) Advancements in risk assessment and prevention strategies (4) Mechanisms underlying arrhythmias leading to SCD (5) Pharmacological and device-based interventions for SCD prevention and treatment (6) Epidemiological studies examining SCD incidence and outcomes (7) Psychosocial impact and support for SCD patients and their families
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Today, the #NEJM (New England Journal of Medicine) published a critically important first clinical study of the presence of micro and nanoplastics (MNP) in carotid arterial plaques, and its impact on cardiovascular health. The findings are worrisome! ⤵️ Among the 257 patients enrolled who underwent excision of carotid plaques, and had post-surgical follow up for 34 months, the investigators detected: 🔎 polyethylene micro/nanoparticles in 58.4% of the patients, which were lodged in their cellular tissue; 🔎 polyvinyl chloride (PVC) micro/nanoparticles in 12% of the patients. 🔎 patients who had MNPs detected had 4.5-fold higher risk toward a composite of myocardial infarction, stroke, or death from any cause at 34 months of follow-up, than those in whom MNPs were not detected. 📌 Whether entering by inhalation or ingestion, MNPs have been found in the tissue and organs of all humans; this study has provided a first indication of the toxicity and harmful health impact of MNPs on cardiovascular health. 🔗 This Recent 2024 review about the harmful health effects of MNPs was discussed in The Lancet (https://lnkd.in/g_HPE8qk?) #microplastics #nanoplastics #publichealth #plasticpollution
Microplastics and Nanoplastics in Atheromas and Cardiovascular Events | NEJM
nejm.org
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Straining to Understand: Using Echo Strain Imaging to Uncover the Anti-Inflammatory Benefits of NOACs This study demonstrates that global longitudinal strain (GLS) measured by speckle tracking echocardiography can improve risk stratification for ventricular arrhythmias (VA) in patients with sickle cell anemia (SCA). Given the potential anti-inflammatory effects of NOACs and the impact of inflammation on GLS, longitudinal studies assessing inflammation, GLS and arrhythmias pre- and post-NOAC therapy can elucidate the anti-inflammatory mechanisms and downstream benefits of NOACs. It is known that inflammatory mediators like cytokines can impair myocardial contractility and reduce GLS values. Additionally, anti-inflammatory treatments have been shown to improve GLS in certain contexts. Prospective cohort studies in SCA patients could perform rhythmic risk stratification with GLS and monitor inflammatory biomarkers before and after initiating NOAC therapy. Observing concurrent improvement in inflammatory status, GLS values, and lowered VA risk with NOAC treatment could demonstrate that reduction of inflammation is a key antiarrhythmic mechanism of NOACs. This would further validate the utility of assessing inflammation and strain forguiding anti-inflammatory interventions to mitigate arrhythmic risk in SCA. In summary, longitudinal assessment of inflammation, GLS, and arrhythmias before and after NOAC therapy can provide greater insight into the anti-inflammatory properties of NOACs and their role in potentially lowering arrhythmic risk in high-risk populations like SCA.
Determinants of ventricular arrhythmias in sickle cell anemia: toward better prevention of sudden cardiac death
ashpublications.org
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HDL and cardiovascular disease, a marker or an effector particle? One of the hardest challenges to physicians/scientists in lipidology and preventive cardiology. We had some hints that HDL mimetic medications would not work even in people with genetic HDL deficiencies (https://lnkd.in/dFVzcaNm) . Now another study shows negative results on the field (https://lnkd.in/dfqsqGar) ! Weight loss, smoking cessation, physical activity, LDL-C lowering are essential to reduce CVD in people with low HDL-C ! #prevention #cardiovascular #cholesterol
CSL Announces Top-line Results from the Phase 3 AEGIS-II Trial Evaluating the Efficacy and Safety of CSL112 (apolipoprotein A-I [human])
newsroom.csl.com
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