BMC’s Post

Catherine Merrick at the University of Cambridge delves into the intricate cell division of the #malaria parasite, unveiling unprecedented insights. Her findings meticulously define replication parameters in blood-stage malaria #parasites, shedding light on species-specific variations. Read more 👉 https://bit.ly/4bnFPEj You can also read this article in Deutsch, Español, Français, Italiano & Polski. Just click on the link and then select the language option at the top of the page. #Genetics #DNA #FrontierResearch

papua new guinea: 50000 years millinea isolated genes: and inherited from extinct: denosivans: humans give them perfect immunity: in lowlands: or hills: blood: mutations: https://lnkd.in/drR83RqR

This variegated sea urchin (𝘓𝘺𝘵𝘦𝘤𝘩𝘪𝘯𝘶𝘴 𝘷𝘢𝘳𝘪𝘦𝘨𝘢𝘵𝘶𝘴) happily uses its tube feet to climb up the tank wall, while its pink food swirls around on the tank floor below. When they aren’t moving around and exploring their tank, this species of urchin has the very important role of acting as a comparison tool for GMGI researchers. While this particular species has a short lifespan (~4 years), a long-lived species (the red sea urchin 𝘔𝘦𝘴𝘰𝘤𝘦𝘯𝘵𝘳𝘰𝘵𝘶𝘴 𝘧𝘳𝘢𝘯𝘤𝘪𝘴𝘤𝘢𝘯𝘶𝘴) is also housed at GMGI just a few tanks over. The red sea urchin lives for hundreds of years without signs of aging or age-related disease. GMGI researchers are fascinated that this species can live so long without developing cancer or showing age-related decline. One way to understand how these red sea urchins are able to live such incredibly long, healthy lives is to compare their genome to that of the short-lived green sea urchin. What are they doing differently? Do they have different gene functions? What makes them cancer-free throughout their long lives? Both species — and their genomes — are critical to the GMGI research team’s work and the potential impacts on human health.

papua new guinea: 50000 years millinea isolated genes: and inherited from extinct: denosivans: humans give them perfect immunity: in lowlands: or hills: blood: mutations: https://lnkd.in/dbAd2f9v

'This study underscores the need to expand resistance monitoring to include An. funestus alongside other vector species, and to screen for both the genetic and phenotypic signatures of resistance. The findings can be visualized online via an interactive user interface and could inform data-driven decision-making for resistance management and vector control. Since this was the first large-scale survey of resistance in Tanzania’s An. funestus, we recommend regular updates with greater geographical and temporal coverage.' https://lnkd.in/gjGheUXj

A study by Brazilian researchers has found the remnants of adenovirus, herpesvirus and papillomavirus DNA sequences among raw sequencing reads of Neanderthal genomes (Homo sapiens neanderthalensis) isolated from bones found in a Russian cave. The researchers found multiple types of human pathogenic DNA viruses (excluding retroviral elements) producing persistent infections. By determining the extent of C-to-T deamination patterns of ancient viral DNAs, the age (approximately 50,000 years) and the viral evolutionary rates  of the sequences (10−5 to 10−8 substitutions/site/year) could be determined. The observed deamination patterns also allowed the researchers to rule out contamination with modern extant viral DNA as a source of the sequences identified in these samples. The viruses detected have dsDNA genomes and can establish lifelong latency leading to persistent infections in humans. Under the same conditions used to identify these viruses,  a nonpersistent DNA virus was not detected above the level of pure random nucleotide similarity. Mutations in multiple genes in these ancient viruses could be identified when compared to the extant closest relatives.  The authors indicate that amplicons obtained by PCR from Neanderthal purified DNA could be sequenced to fill low coverage regions, a process that could  potentially allow the full reconstruction of these paleoviruses. This important study shows proof-of-concept for the detection of human viruses in ancient human genomes, and opens the doors for the use of paleogenomics to study the evolution of human transmissible diseases caused by persistent viral infections. #evolution #viruses #Neanderthal #paleogenomics #herpesvirus #globalhealth #publichealth #medicine #biotechnology #scienceandinnovation https://lnkd.in/gjm2ipGW

While a lot of unknowns remain around the treatment response of #Borrelia burgdorferi s.l., one aspect is the genetic variation of the bacteria itself. New research has made progress in mapping the genetics of Borrelia. https://lnkd.in/g-ywsgcB

Evolutionary dynamics of the accessory genomes of Staphylococcus aureus https://lnkd.in/gekbeKmt

Interesting read for those who are in the field of ID and evolutionary biology.

Wan to know more about phylodynamics? Fogarty's Nídia Trovão explains the basics of this scientific area of study of how various processes act and potentially interact to shape the evolutionary development and diversification of pathogens. https://lnkd.in/dbzNJ3rS #Fogarty #GlobalHealth #epidemiology