biomodal’s Post

I have understood (and in a past life, researched) the importance and impact of tuning gene expression in a non-binary way and it's future therapeutic potential. But this explanation comparing epigenome control to musical orchestration brilliantly portrays the complexity and possibility of creating a therapeutic symphony, a recommendation for anyone, in/out of the biotech world! #genetherapy #geneediting https://lnkd.in/epTxbyyc

🔓New #OpenAccess research in Physiological Genomics: Transcriptional response of the #heart to vagus nerve stimulation (Daniel O. Kellett et al.) https://ow.ly/SbYf50Qrh8l #vagusnerve #RNAsequencing #transcriptome #autonomicnervoussystem

The sequential evolutionary loss of Y chromosome genes are a great concern in modern research because scientists predict that if the gene losses are going on in this manner it will be possible in future the male sex will be annihilated. Some study showed that Y chromosome originated from the X chromosome through a process of degeneration and gene loss. If we clearly understand which genes are degenerated and lost for producing Y chromosome then the Y chromosome based research turns into a great initiative. The SRY genes located in the Y chromosome are primarily involved in male sex characteristics and testes development, I think it will be effective to find that where the SRY gene comes from. Assessment of Y chromosome gene loss based health problems or cellular characteristics unrevealing the path for Y chromosome research. Gene therapy, RNAi technology can be helpful in Y chromosome research through which genes are protected from degeneration. I think researchers should be focused on phenotypic behaviour related to Y chromosome gene loss from the ancient time and data analysis to develop some techniques for stopping the gene loss from Y chromosome.

InstaDeep's Javier Mendoza-Revilla, PhD will share how AI systems - and LLMs specifically - are deepening our understanding of the Maize genome tomorrow at 7:20 pm at the Maize Genetics Meeting in Raleigh, NC. #MGM2024 Read the research paper: “A Foundational Large Language Model for Edible Plant Genomes” https://lnkd.in/gA6-eG5J And read the independent benchmark study in which researchers found InstaDeep’s Nucleotide Transformer outperformed all other genomics Language Models on gene finding and annotation: “BEND: Benchmarking DNA Language Models on biologically meaningful tasks” https://lnkd.in/gSBXPbAt

Simply "mutating" (digitally varying the bases) of inputs into DNA language models drops out an enormous number of functional genomic elements. Heatmaps of the pairwise nucleotide dependencies can clearly show the entire secondary structure of tRNAs (see figure). These maps can also show DNA regulatory motifs and TF binding sites—seemingly as accurately as models training on experimental binding data... We're just scratching the surface of neural network interpretability for genetics. Study: https://lnkd.in/gXmTSbmv

The Y Chromosome Crisis – A Silent Evolutionary Shift?** In recent times, the Y chromosome, a symbol of male identity and lineage, has sparked intense scientific debate. Researchers are uncovering evidence that this small but mighty chromosome may be facing an unprecedented evolutionary challenge. 🚨 **What’s Happening?** The Y chromosome is shrinking, and some studies suggest that it could disappear in a few million years if current trends continue. This phenomenon is attributed to the loss of crucial genes over time, raising concerns about male fertility and genetic diversity in the long term. 🔬 **Why Does It Matter?** While the potential loss of the Y chromosome sounds alarming, it's essential to remember that nature is incredibly resilient. Some species have already lost their Y chromosome but have found alternative genetic mechanisms to determine sex. However, the implications for humans are still a topic of active research. 🌍 **What Can We Do?** Innovative technologies like CRISPR are at the forefront of potentially mitigating this crisis. By understanding and preserving the essential functions of the Y chromosome, we can ensure that future generations maintain genetic diversity and health. As we navigate this evolving landscape, it's crucial to stay informed and support research that could pave the way for groundbreaking solutions. The Y chromosome crisis is not just a scientific curiosity—it's a profound reminder of the delicate balance in our genetic makeup and the importance of proactive research. 🔗 **Let’s start a conversation:** What are your thoughts on the Y chromosome crisis? How do you think biotechnology will shape the future of human genetics? #Genetics #YChromosome #CRISPR #Biotechnology #Evolution #Health --- This post is crafted to encourage discussion, share critical insights, and position you as knowledgeable about cutting-edge scientific issues.

It means you are not victim of your genes: "When the human genome was sequenced in 2001, many thought that it would prove to be an ‘instruction manual’ for life. But the genome turned out to be no blueprint. In fact, most genes don’t have a pre-set function that can be determined from their DNA sequence.Instead, genes’ activity — whether they are expressed or not, for instance, or the length of protein that they encode — depends on myriad external factors, from the diet to the environment in which the organism develops. And each trait can be influenced by many genes. For example, mutations in almost 300 genes have been identified as indicating a risk that a person will develop schizophrenia.A tour of the evolution of mindsIt’s therefore a huge oversimplification, notes Ball, to say that genes cause this trait or that disease. The reality is that organisms are extremely robust, and a particular function can often be performed even when key genes are removed. For instance, although the HCN4 gene encodes a protein that acts as the heart’s primary pacemaker, the heart retains its rhythm even if the gene is mutated." https://lnkd.in/eaMgA-7C

RNA (Ribonucleic Acid) is a molecule that makes protein that helps carry out the instructions stored in DNA (Deoxyribonucleic Acid). Scientists have recently discovered that certain types of RNA, called noncoding RNAs, don't make proteins but instead control how genes work, deciding when they are turned on or off. This important discovery earned Victor Ambros and Gary Ruvkun the Nobel Prize in Physiology or Medicine. #dna #nobelprize #sciencecommunication #highschool Image by AI. Source https://lnkd.in/eWtghd7p

The captivating world of circadian and quantum biology's profound influence on biological systems is fascinating. In a new post, I delve into the intricate mechanisms and compelling evidence that establish light as a more fundamental regulator of various physiological processes than food. TL;DR: Light plays a crucial role in circadian rhythms by synchronizing the suprachiasmatic nucleus, influencing hormone secretion, metabolism, and gene expression. It also regulates melatonin production, which is critical for sleep-wake cycles and cellular health. In quantum biology, light affects photoreceptor proteins and quantum coherence, while the dominance of light over food in circadian regulation is highlighted through hierarchical synchronization and evolutionary perspectives. Are you ready to explore the cutting-edge insights and implications in circadian and quantum biology? Join me in uncovering the fascinating world of biological rhythms and light's pivotal role in shaping our health and well-being. #CircadianBiology #QuantumBiology #HealthScience #BiologicalRhythms https://lnkd.in/g83zs_Tz

“In genetics, mutations are often the mistakes that happen when genes copy one another. Such mistakes can lead to fascinating new chemical combinations which can in turn lead to the evolution of entirely new forms.” {Gene Key 19} Reflect on places where you’ve felt you made a mistake; can you see how in the long chain of events following, something new was birthed from it? Something that could have never been before without that specific ‘mistake’ and mutation? It’s similar to the art form of improv dance. When we’re dancing with another and we lose the flow, we have the choice to stop because we perceived we made a mistake or... We see it as part of the dance and allow that glitch. fall, or bump to become part of what inspires the next movement. Just as it works in DNA coding and improv dance, so it too works in the realm of our life. Let every glitch, fall, or bump turn into your greatest mutation towards the evolution of your most epic life. It’s all in perception. #selfexpression #connection #embodiment