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On-demand Webinar: Accelerate the Use of iPSC-derived Organoids in Drug Discovery & Personal Medicine. An excellent opportunity to gain insights into a novel approach that addresses the limitations faced by current organoid workflows. Webinar Recording Link: https://hubs.ly/Q02nzwBR0 Presented by Allysa Stern, Ph.D., Scientist II, Product Applications at Cell Microsystems, this session delves into challenges within existing workflows, offering solutions to inefficiency, labor-intensive processes, and limitations in heterogeneity and throughput. #iPSCorganoids #DrugDiscovery #CellRaftTechnology

My colleague, Margaret (Mache) Cruz, presented our research on "Facile Extraction of α2 Beta Casein Milk-Derived Extracellular Vesicles and Their Impact on C2C12 Cell Migration" at BMES. This research highlights how milk-derived EVs can enhance cell migration in C2C12 murine myoblasts, showcasing their potential in therapeutic applications for tissue healing. We are proud of our team's dedication to advancing biomedical engineering. #BiomedicalEngineering #ResearchInnovation #ExtracellularVesicles #TissueEngineering #CMUEngineering

Understanding molecular variation in the brain is key for our understanding of neurological disorders, yet current methods miss the mark. This case study highlights Jonathon Mill and team’s multiomic approach using #nanopore technology to characterise both epigenetic and transcriptional variation in the brain. It shares how nanopore technology enabled the characterisation and quantification of thousands of novel isoform transcripts (including 11 linked to Alzheimer’s disease), the identification of millions of CpG sites as well as the detection of DNA modification 5-hydroxymethylcytosine — a modification critical in regulating alternative splicing in neurons, but hard to differentiate using alternative methods1. Find out more: https://bit.ly/4gja3eX

🔬 Nikon Instruments debuts AX R with NSPARC 2K software for biotechnology research AX R with NSPARC 2K software is designed to offer maximum resolution performance across four times the field of view. It is the latest addition to Nikon’s AX series lineup. The enhanced functionalities of the AX R equipped with the NSPARC Super-Resolution Confocal Microscope is said to accelerate the speed and efficiency of experiments in fundamental biology, disease research, and drug development. The Nikon Spatial Array Confocal (NSPARC) detector, integrated with the AX R Confocal Microscope system, facilitates more accurate observations with minimal noise and sharp image contrast. Read more online: https://lnkd.in/e4WA-QTg 📰 Follow Medical Device Developments to receive the latest medical device news daily and to subscribe to our weekly newsletter #MedicalDeviceDevelopments #medicaldevices #medicalmanufacturing

Check out our most recent publication (my 2nd 1st-authored research article) in Science Advances demonstrating tissue-specific morphogenesis in a hiPS cell-derived kidney-on-a-chip model. https://lnkd.in/etS3bXr4 In this study, we showed that utilizing an ultrathin biomimetic membrane in an organ-on-a-chip device, hiPS cell-derived generic vascular endothelial cells were spontaneously induced into more specialized fenestrated endothelial cells in situ, in the presence of podocytes, through VEGF signaling. This work is listed as the featured paper in the 07 JUN 2024 issue. #scienceadvances #organonachip #musahlab #dukeuniversity

Cellsonics is excited to bring you this webinar featuring David Ferrick, PhD and CEO of Cellsonics.    Sourcing abundant, high quality ex-vivo single cells, whether for cell sorting, single cell RNA-Seq, or cell outgrowth like organoids, is a crucial step in single cell workflows. Despite its importance, innovation in tissue dissociation has lagged, with current workflows remaining complex and dissociation conditions often harsh on the single cells of interest.    In this webinar David will introduce the SimpleFlow System which performs non-enzymatic tissue dissociation. The SimpleFlow System utilizes acoustic energy to isolate single cells from complex tissues. This method offers a rapid alternative to intricate mechanical or harsh enzymatic dissociation techniques, preserving a high yield of live cells and more accurately maintaining the native tissue's heterogeneity. https://lnkd.in/emXf8KVx

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🚨 Happy to share my first work accepted at NeurIPS MLSB workshop: "Systems-Structure-Based Drug Design." Building on previous insights into the connection between systems and structural biology. https://lnkd.in/gGqXQiyN We are able to identify probable protein-protein binding sites. Once identified, we perform an evolutionary analysis to identify "hot spots" for probable orthosteric small molecule binding sites that interrupt BMP ligand-receptor interactions. Once the "hot spot" is identified for both the target of interest and competing pocket(s), we use the Bio-Diffusion small molecule generation diffusion model to create new small molecules of varying sizes for the pocket. We guide the generation with DiffDock-Pocket confidence model of the predicted denoised small molecule fit to the "hot spot" of interest. Problem: this isn't differentiable. Solution: simple gradient approximation and checkpointing. The former is self explanatory but the latter was a revelation that you could take the best prediction out of a sample in the generation process and that would help guide the small molecule generation. We applied this method to the Bone Morphogenetic Protein (BMP) pathway for two complexes of interest and, for three different sizes of molecules, were able to generate small molecules that were more specific to the "hot spot" of interest. The confidence of DiffDock methods isn't the same as binding affinity so we checked the binding affinity for one small molecule using AutoDock Vina and found the confidences correlated with worse/better binding affinity! (n=1, though) Come visit the poster & chat at the NeurIPS MLSB 2024 workshop in Vancouver if you're interested in learning more. #drugdiscovery #bayesian #diffusion

I highly recommend this webinar to all interested in drug discovery and development!

🤔 Did you know that using a different mixing platform can change the morphology of your drug product?     👩🔬 We designed a study in conjunction with Phosphorex in order to demonstrate how #cryoTEM analysis compares to techniques like DLS and Ribogreen assay. We compared four #lipidnanoparticle formulations and saw surprising differences in morphology.   🔬 Cryo-TEM imaging reveals unique details about nanoparticle formulations that cannot be revealed with other methods.    📩 Download the whitepaper to see the results: https://lnkd.in/gia_uTZc