Do you require chemical manufacturing services that prioritize customer satisfaction, meeting quality and regulatory needs while making difficult-to-make materials? Biosynth provides an extensive array of chemistry services catering to diverse industry needs. Whether you operate in pharmaceuticals, biotechnology, vaccine development, or any other sector seeking chemical expertise, Biosynth offers tailored solutions. From process design, scouting, and optimization to GMP production, our comprehensive services cover every aspect. Our exceptional team of chemists and scientists possess leading expertise in organic synthesis, medicinal chemistry, process development and analytical services. With unrivaled proficiency in carbohydrate and nucleoside chemistry, enzyme substrates, and chemical intermediates, challenging projects are a part of our everyday business. We are also licenced to manufacture controlled drugs in our synthetic chemistry facilities to ensure supply to pharma customers. Should you require unique compounds or specialized chemical structures, our custom synthesis services are here to bring your vision to life. . To learn more about our exceptional chemistry services, visit our website: https://lnkd.in/ewD9va8S Or contact our team today: https://lnkd.in/e7cXNb25 #FirstIdeaToFinishedProduct #ChemistryServices #ChemicalManufacturing #ResearchandDevelopment #GMPProduction #ChemistryExperts #ScientificSolutions #ChemistryInnovation #ScienceAndTechnology
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A subtle change in chemical structure entails a significant alteration in pharmacokinetic and toxicity profile of deuterated drugs, potentially translating into improvements in efficacy and safety compared with the non-deuterated counterparts. Deuterium labelling in novel drug discovery has gained a momentum identifying a potential drug candidate through deuterium switch approach as well as exploring de-novo synthesis of deuterated products. The FDA approval of deuterated drug Deucravacitinib in year 2022, signifies the importance of deuterium labelling in drug discovery. Chemtatva Chiral Solutions (CCS) specialize in the chemistry of deuterium labelling includes the synthesis of stable isotopes for intended pharma and OLED application. The product portfolio includes: - Aliphatic and Aromatic Deuterated compounds, - Deuterated solvents, - Deuterated derivatives in lab to commercial scale. We are leading supplier of CD3NH2.HCl (methylamine-d3 HCl salt) CAS 7436-22-8, a key RM in Deucravacitinib and support in all CMC requirements includes- 1. ROS and VQ docs 2. D1/D2 content analysis 3. D1/D2 impurities supply 4. Site audit Plz contact us to discuss further on topic. email- vishalrajput@chemtatva.com M- 919704500275 www.chemtatva.com #Generics #API #NCE #CMC #CDMO #Drugs #Discovery #FDA #Approvals #Deucravacitinib #Deuterium #Isotopes #Intermediates
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Flexibility from Shimadzu for your analytical and prepartivr LCMS needs #hplc #analytical #preparative #purification #lcms
Preparative HPLC is utilized in various fields, such as pharmaceuticals, food, and chemical engineering, for purifying target compounds from mixed samples, searching for active ingredients in natural products, and analyzing the structures of impurities and unknown compounds. This article presents an efficient preparative purification workflow, which includes investigating separation conditions at analytical scale, scaling-up for fractionation, and confirming purity and recovery rate. All of these processes are carried out using single analytical/preparative convertible LC-MS system. Check the article: https://zurl.co/JtR8 #Shimadzu
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Chemist 🧪 | Undergraduated at Faculty Of Science (Special Chemistry Department) Alazhar University | PR | HR | SPE | Sci Gate | URI | Chemical Products | Petroleum ⛽| QC | QA | R&D | Content Creator | Research Trainer
Chromatography, a cornerstone technique in analytical chemistry, continues to revolutionize various fields with its unparalleled ability to separate and analyze complex mixtures. Key applications: • Pharmaceutical industry: Drug purity testing and development • Food & Beverage: Quality control and safety testing • Environmental science: Pollutant detection and analysis • Forensics: Chemical evidence analysis • Biotechnology: Protein and DNA analysis How it works: Chromatography relies on the differential partitioning of components between a stationary phase and a mobile phase. As the sample moves through the system, components separate based on their unique interactions with these phases. From simple paper chromatography to advanced HPLC and GC-MS systems, this technique has evolved to meet diverse analytical needs across industries. Embracing chromatography means unlocking a world of molecular insights, paving the way for groundbreaking discoveries and innovations. What's your experience with chromatography? Share your thoughts below! 👇 #Chromatography #AnalyticalChemistry #LaboratoryTechniques #ScienceAndTechnology #PharmaceuticalIndustry #FoodScience #EnvironmentalAnalysis #Forensics #Biotechnology #HPLC #GasChromatography
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R&D Section Head Methodology & Stability ,Team Leader Research and Analytical Development & Validation |Scientist|TQM |QMS|Bachelor of Science in Special Chemistry🥼🧪🔬
Difference between hydrophilic and hydrophobic syringe filter membrane: 1. Hydrophilic Syringe Filters: - These filters are easily wetted by aqueous solutions. - Ideal for filtering water-based samples or samples containing polar solvents. - Common applications include: - Biological sample preparation: Used for cell cultures, protein solutions, and buffers. - Environmental and water analysis: Essential for removing particulates and contaminants from aqueous samples. - Pharmaceutical and biotechnology: Filtration of aqueous drug formulations and water-based solutions. 2. Hydrophobic Syringe Filters: - Do not wet in water, but they do wet in low surface tension liquids (e.g., organic solvents like alcohols). - Useful for applications where water repellency is desired. - Not suitable for aqueous samples due to their water-repelling behavior. In summary, hydrophilic filters attract water, while hydrophobic filters repel it. Choose based on your specific application needs. #HPLC #Chromatography #Chemistry #Science #Chemist #Scientist #GMP #GLP #QC #QA #Quality #TQM #QMS #RnD #Validation #Analytical #Development #Research #Pharmaceuticals #Inspire #Pharma #USP #EDA #BP #ICH #FDA #WHO #Dissolution #UV #Saftey
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Senior Research Scientist | CRO | 3xper | Organic Synthesis | Process development
Crystallization is an essential tool for organic synthesis #crystallization #organicsynthesis #cro #processdevelopment #API #Bulkmanufacturing #Synthesis #Organicchemistry
Understanding the Differences: Crystallization vs. Crash Crystallization 💎🔬 Crystallization is a fundamental process in various industries, from pharmaceuticals to food production. However, there's often confusion between standard crystallization and crash crystallization. Let's clear that up! Crystallization 🌡️: This is a controlled process where a solution is gradually cooled or solvent is slowly evaporated to form solid crystals. The goal is to achieve high-purity crystals with a consistent size and shape. This method ensures a smooth and controlled formation, allowing for better quality control and predictability. Crash Crystallization ⚡: This method often involves a rapid change in conditions, such as quickly cooling the solution or adding an anti-solvent. Crash crystallization can also occur when a solution becomes too supersaturated before nucleation happens. The excessive supersaturation forces the solute to “crash out” of the solution abruptly. While this can be useful for quick results, it often leads to less uniform and lower purity crystals (as more impurities and solvents tend to become trapped in the crystal mass) compared to the controlled approach. To avoid crash crystallization during a recent recrystallization procedure, we added a suspension of seed crystals as the hot solution slowly cooled, allowing crystallization to occur gradually, and avoiding the solution becoming too supersaturated. Do you have more recrystallization tips? Feel free to share your experiences or ask questions about these processes in the comments! Epichem is Australia's leading CRO for medicinal, synthetic & analytical chemistry services. Visit us at www.epichem.com or email us at sales@epichem.com. #Chemistry #Crystallization #CrashCrystallization #Science #Research #MaterialScience #Pharmaceuticals #Epichem
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🔬🌱 Our article, "IR-EcoSpectra: Exploring sustainable FTIR applications for green chemical and pharmaceutical analysis," has been published in the Journal of Pharmaceutical Analysis, Elsevier. You may find the article here: https://lnkd.in/durAuvVp This review delves into the world of Fourier transform infrared spectroscopy (FTIR), highlighting its unique ability to detect and characterize complex chemicals while minimizing environmental impact. By reducing waste generation and the use of harmful reagents, FTIR emerges as a powerful tool for sustainable analysis in the chemical and pharmaceutical industries. The article showcases the versatility of both ex situ and in situ FTIR applications, from substance identification to dynamic monitoring. Ex situ FTIR offers precision in identifying impurities and monitoring processes, enhancing product quality and safety. Meanwhile, in situ FTIR provides real-time insights into molecular changes during reactions and processes, contributing to innovation in drug development and quality control practices. Our team would be grateful for your interest and feedback! #FTIR #Sustainability #ChemicalAnalysis #PharmaceuticalResearch
IR-EcoSpectra: Exploring sustainable ex situ and in situ FTIR applications for green chemical and pharmaceutical analysis
sciencedirect.com
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𝐂𝐡𝐫𝐨𝐦𝐚𝐭𝐨𝐠𝐫𝐚𝐩𝐡𝐲 𝐑𝐞𝐚𝐠𝐞𝐧𝐭𝐬 𝐌𝐚𝐫𝐤𝐞𝐭: 𝐓𝐞𝐜𝐡𝐧𝐨𝐥𝐨𝐠𝐢𝐜𝐚𝐥 𝐀𝐝𝐯𝐚𝐧𝐜𝐞𝐦𝐞𝐧𝐭𝐬 𝐚𝐧𝐝 𝐈𝐧𝐧𝐨𝐯𝐚𝐭𝐢𝐨𝐧𝐬 𝟐𝟎𝟐𝟑 𝐭𝐨 𝟐𝟎𝟑𝟎 🧪🔬💧 𝗥𝗲𝗾𝘂𝗲𝘀𝘁 𝗳𝗼𝗿 𝗦𝗮𝗺𝗽𝗹𝗲 𝗣𝗗𝗙: https://lnkd.in/dYTitWS2 Chromatography reagents, essential for qualitative and quantitative analysis of chromatography samples, encompass solvents, buffers, derivatization agents, and additives, chosen based on chromatography type. Market growth is propelled by increasing R&D investment in pharmaceuticals and biotechnology, stringent environmental policies aiming to curb pollution, chromatography's pivotal role in food safety and quality testing, and the burgeoning biopharmaceutical sector. Environmental concerns are increasingly being addressed through expanding policies and initiatives, reflecting a broadening effort to combat pollution amid rising global population pressures. *𝐁𝐲 𝐓𝐲𝐩𝐞 : solvents, buffers, derivatization reagents, ion-pair reagents, and other types. *𝐁𝐲 𝐀𝐩𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧 : pharmaceutical and biotech sectors, encompassing research and drug development, pharmaceutical manufacturing, and quality control. *𝐊𝐞𝐲 𝐏𝐥𝐚𝐲𝐞𝐫𝐬 : Bio-Rad Laboratories, Waters Corporation, Santa Cruz Biotechnology (SCBT),. Merck KGaA, Darmstadt, Germany, Thermo Fisher Scientific, Agilent Technologies, Regis Technologies,. Aladdin Shanghai Biochemical Technology Co., Ltd., AVANTOR PERFORMANCE MATERIALS, INC HEALTH CENTER, Loba Chemie Pvt. Ltd. *𝐁𝐲 𝐑𝐞𝐠𝐢𝐨𝐧 : North America, Europe, Asia-Pacific (APAC), Latin America and Middle East & Africa #ChromatographyReagents #AnalyticalChemistry #LabTech #Biotech #Pharma #ChromatographyColumns #SeparationScience #ChemicalAnalysis #ResearchTools #ChromatographySupplies #HPLC #LCMS #GCMS #BiochemicalAnalysis #ChromatographyExperts #ChromatographyConsumables #ChromatographyInstruments #ScienceAndTechnology #LabInnovation #ChemicalIndustry
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Reducing the Process Mass Intensity is one of the main objectives of process development methodology. Seqens R&D scientists and technologists use this key indicator to define improvement targets, and drive the experimental plan. While ensuring product quality and process safety, technological choices are ultimately driven by this criterion of optimizing raw materials consumption. Sustainable and economical routes of synthesis allow our customers to meet their CSR targets in terms of carbon footprint reduction. Contact us at cro@seqens.com to explore process optimization solutions #seqens #processintensification #corporatesocialresponsibility
[Process Mass Intensity] Decreasing the amount of resource usage to make an Active Ingredient is one of the major green chemistry challenges for the pharmaceutical industry. Process mass intensity (PMI) is the key green mass-based metric for measuring the resource usage impact of a synthetic chemistry process. ♻️ Still, improving PMI doesn’t necessarily mean changing the core reaction route nor reactants of an API synthesis. 𝗜𝘁’𝘀 𝗮𝗯𝗼𝘂𝘁 𝘀𝗼𝗹𝘃𝗶𝗻𝗴 𝗶𝘀𝘀𝘂𝗲𝘀 𝗿𝗲𝗹𝗮𝘁𝗲𝗱 𝘁𝗼 𝘁𝗵𝗲 𝗽𝗿𝗼𝗰𝗲𝘀𝘀 𝗰𝗼𝗻𝗱𝗶𝘁𝗶𝗼𝗻𝘀 𝗯𝘆 𝗿𝗲𝗮𝗰𝘁𝗶𝗼𝗻 𝗲𝗻𝗴𝗶𝗻𝗲𝗲𝗿𝗶𝗻𝗴 Typically, understanding the kinetics and the key process parameters, can allow drastic PMI improvement. 📈 Based on the initial lab conditions, reaction engineering such as: ✔️ Reagents concentrations and solvent screening. ✔️ Implementing physical operations modeling for precisely measuring the conditions required for switching solvent system. ✔️ Solvent volumes for product extraction organic/aqueous media. ✔️ Solvent volumes for a recrystallization step and/or washing the cake. These studies can significantly decrease the process mass intensity (PMI) by more than 60 % with respect to the original process. Moreover, this can also positively impact the product quality. #processintesification #greenchemistry #sustainability #pharmaceuticals #ourscienceforyourfuture
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Optimizing Organic Chemistry Process Development: From Lab to Large-Scale Production https://lnkd.in/eMucf3GJ Organic chemistry process development is a critical step in scaling up chemical reactions from the laboratory to industrial production. This blog post delves into the methodologies and strategies used to optimize chemical processes, ensuring efficiency, safety, and sustainability. Learn about the latest innovations in process development, key challenges in scaling up, and how these advancements are transforming the pharmaceutical, agricultural, and chemical industries. #Organic chemistry #Processdevelopment #Chemicalprocess optimization #Scale-up production #Lab to industrial scale #Processsafety #Greenchemistry #Reactionengineering #Pharmaceutical process development #Chemicalmanufacturing
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Discover the hidden wonders of the microscopic world with our precision microscopes. Perfect for students, professionals, and researchers, advanced technology brings even the tiniest details into sharp focus. Take your research and learning to the next level! For more information visit srdpharma.com #Microscopy #ScienceTools #ResearchEquipment #pharmaceuticals #pharma #chemistry #biology #microbiology #microscopy #research #drugs #Clinical #Laboratory #Scientists #lab #tests
Independent Analytical Laboratory & Chemicals Analysis & Testing - SRD Pharma
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