𝗦𝘂𝗽𝗲𝗿𝗰𝗵𝗮𝗿𝗴𝗲𝗱 𝗹𝗶𝗴𝗵𝘁 𝗲𝗺𝗶𝘁𝘁𝗲𝗿𝘀: 𝗻𝗼𝗿𝗯𝗼𝗿𝗻𝘆𝗹 𝗮𝗻𝗱 𝗵𝗼𝗺𝗼𝗰𝘂𝗯𝗮𝗻𝘆𝗹 𝘀𝗽𝗶𝗿𝗼𝗳𝘂𝘀𝗲𝗱 𝗱𝗶𝗼𝘅𝗲𝘁𝗮𝗻𝗲𝘀 𝗳𝗼𝗿 𝗲𝗻𝗵𝗮𝗻𝗰𝗲𝗱 𝗰𝗵𝗲𝗺𝗶𝗹𝘂𝗺𝗶𝗻𝗲𝘀𝗰𝗲𝗻𝗰𝗲! Biosynth Researchers working with Doron Shabat's group have published exciting work on accelerating the chemiexcitation of phenoxy-1,2-dioxetanes (a fancy way of saying making them emit light faster): 👉 https://lnkd.in/eauGGz4N Their secret weapon? Spirofusion with bicyclic 7-norbornyl and polycyclic homocubanyl units! The high strain in homocubanyl led to a phenomenal chemiexcitation rate, but stability issues emerged. However, the norbornyl counterpart provided a fantastic compromise – significantly faster chemiexcitation than the classic adamantyl version, with good stability. They even built a "turn-ON" probe for beta-galactosidase detection that showed a 9-fold improvement in sensitivity. This work is dedicated to the memory of 𝗣𝗿𝗼𝗳. 𝗣𝗵𝗶𝗹𝗶𝗽 𝗘. 𝗘𝗮𝘁𝗼𝗻, a cubane pioneer. At Biosynth, we have also recently honored him by publishing a blog post about his life and the "impossible molecule". 👉 https://lnkd.in/efDB6gAr #chemiluminescence #dioxetanes #cubane #biosensors
Reinhard Karge
3mo
Really exciting molecules
Congrats Sara, Doron, and Biosynth team!!
Board of Directors Biosynth Group
3moBeautiful work. Thank you, team!