Biosynth’s Post

AmbioPharm has a dedicated focus on peptide projects. Unlike some CDMOs with broad capabilities, we are proud to be experts in peptide manufacturing and development. Our depth of peptide synthesis experience and expertise spans a range of peptide project scales and compound complexities. From process development to commercial manufacturing, it helps to have experience at your side.   Learn more about how we can help you achieve success in your clinical peptide project: https://lnkd.in/dPvjCZXd #cgmp #peptides #cdmo #api #drugdevelopment #peptidesynthesis #peptidetherapeutics

Development of nanostructured lipid carrier containing tea tree oil: Physicochemical properties and stability. https://ow.ly/mVUI50Qx3bi #Pharmacy #Pharmacology #NaturalProducts #PharmaceuticalTechnology

At Sris Synthesis Pvt. Ltd., we are committed to maintaining the highest standards of quality and consistency in our products. Our rigorous quality control processes ensure that researchers and manufacturers receive reliable and pure 3-Bromo-5-chloro-6-ethylpyrazine-2-carbonitrile, empowering them to drive innovation and achieve breakthrough results. Our rigorous quality control processes ensure the reliability and purity of our products, empowering researchers and manufacturers to achieve breakthrough results. With a focus on excellence and customer satisfaction, Sris Synthesis Pvt. Ltd. stands as your trusted partner in sourcing essential chemical compounds for scientific and industrial innovation. Product                       : 3-Bromo-5-chloro-6-ethylpyrazine-2-carbonitrile Chemical Formula      : C7H5BrClN3 CAS Number               : 2043020-03-5 Molecular Weight      : 246.49 Purity                          : >98% 3-Bromo-5-chloro-6-ethylpyrazine-2-carbonitrile is a highly specialized chemical compound widely utilized in pharmaceutical and chemical research. Characterized by its unique combination of bromine, chlorine, and ethyl groups, this compound serves as a crucial intermediate in the synthesis of various biologically active molecules and pharmaceutical agents. Its distinct structure and chemical reactivity make it indispensable for researchers focused on developing novel therapeutics targeting diverse biological pathways and disease mechanisms. In the field of pharmaceutical research, 3-Bromo-5-chloro-6-ethylpyrazine-2-carbonitrile is particularly valued for its versatility and efficacy. It is employed in the design and synthesis of new drug candidates, contributing to efforts aimed at improving drug efficacy, reducing side effects, and addressing unmet medical needs. The compound's unique properties enable researchers to explore innovative solutions in medicinal chemistry, ultimately leading to the development of advanced therapeutics. Call: +91 99895 22441 Mail: chari@srissynthesis.com   | sales@srissynthesis.com Web: www.srissynthesis.com #BromoChloroPyrazine #ChemicalIntermediates #SrisSynthesis #CustomSynthesis #Impurities #Isolation #R&DMolecules #PharmaceuticalProducts #DrugDevelopment #MedicinalChemistry #OrganicSynthesis #BiologicallyActiveMolecules

Optimize your drug discovery, formulation, and process control by combining two powerful characterization techniques. Discover our #biopharma lab package specifically designed to expedite drug development: https://lnkd.in/ekzqUnbP #Biopharmaceuticals #DrugDiscovery

Cyclosporine A (CsA), a potent immunosuppressive drug used to treat autoimmune diseases and prevent organ transplant rejection, requires high purity for safety and efficacy. Impurities can lead to side effects and toxicity. Recent advancements in High-performance liquid chromatography (HPLC) have improved CsA purification, but challenges remain in achieving purity levels above 95%. This study employed a multi-step HPLC method to enhance CsA purity. After exploring various HPLC conditions, including mobile phase solutions and temperature, the optimal method was determined. Using acetonitrile-water-tert-butyl methyl ether-phosphoric acid (430:520:50:1) as the mobile phase, with a column temperature of 70 °C and specific chromatography column specifications, an average CsA yield of 80.1% with 97.2% purity was achieved. This method shows promise for enhancing CsA purity and safety in pharmaceutical applications. Please visit: https://lnkd.in/gSs2iwhv #research #chemistry #engineering

Development of nanostructured lipid carrier containing tea tree oil: Physicochemical properties and stability. https://buff.ly/3uU5Riq #Pharmacy #Pharmacology #NaturalProducts #PharmaceuticalTechnology

2-azabicyclo[2.2.1]heptane building blocks Conformational restriction is an emerging strategy applied in current drug discovery programs to modify the pharmacological characteristics of bioactive molecules. Among them, the conformationally restricted 2-azabicyclo[2.2.1]heptane analog has greater potential to complement the spatial subtleties and selectivity for target proteins owing to the three-dimensional structure and stereochemical properties. Moreover, the framework possesses high Fsp3 and low log D that are important elements for drug development. So far, Chemscene has developed many 2-azabicyclo[2.2.1]heptane building blocks. For more information, please visit www.chemscene.com or contact us at sales@chemscene.com. #DrugDiscoveryInnovation #ChemicalSynthesis #Pharmacology #MedicinalChemistry #ConformationalRestriction #Stereochemistry #TargetedTherapeutics #Chemscene #BuildingBlocks

Surface-enhanced transmission Raman spectroscopy (SETRS) can be employed to detect impurities in complex matrices, study shows. Paving the way for new quantitative applications. Currently, the US Pharmacopeia recommends liquid chromatography for the quantitative determination of 4-aminophenol (4-AP), a degradation impurity of paracetamol. However, the study’s authors targeted to explore SETRS, a spectroscopic technique that is more time-efficient and eliminates the need for organic solvents typically required in separation methods. Find out more: https://lnkd.in/dxBgMpib #afripharmareview #qualitycontrol #raman #pharmaceuticals

Preparation Techniques of Polypeptide - Physical Extraction method. It is a new concept proposed in recent years. This method does not need any chemical #reagents when preparing the #peptides. It is based on an ultrahigh-pressure continuous cell flow instrument, which can break up more than 90% of E. coli cells. Therefore, after breaking by the instrument, all animal or plant tissue has been lysed, the cell wall and cell membranes have been ruptured, and active #ingredients in cells have been released and become peptides by continuous cell flow lysing. This method ensures the biological activity of the polypeptide to the greatest extent, but it requires high equipment with a single processing volume and low polypeptide yield, so it is not suitable for industrial production. #biopharma #biological #physical #biopharmaceutical https://lnkd.in/gRM9Xurm

Bioactive compounds screening of Rafflesia sp. and Sapria sp. (Family: Rafflesiaceae) as anti-SARS-CoV-2 via tetra inhibitors: An in silico research. https://buff.ly/3TmgQLX #Pharmacy #Pharmacology #COVID-19 #NaturalProducts